Monooctanoin perfusion for in vivo dissolution of biliary stones. A series of 11 patients.

Abstract:

:Monooctanoin, a cholesterol solvent, was infused into the biliary system of 11 patients. Twenty-eight (74%) of 38 total stones responded to monooctanoin: 16 (42%) decreased in size, and 12 (32%) dissolved completely. Ten stones (26%) did not change in size. We attribute this to inadequate drug-stone contact, which was corrected by placement of the infusion catheter contiguous to the stone(s). The use of a second catheter for biliary drainage avoided the side effect of biliary colic and increased patient compliance. An infusion rate greater than 5 ml per hour invariably produced pain and diarrhea. There were no significant side effects from monooctanoin in any of our patients when a two catheter system and an infusion rate of 5 ml per hour or less were used. A major drawback to use of this still experimental agent is the prolonged hospital stay. This may be ameliorated when at home use of monooctanoin is approved.

journal_name

Radiology

journal_title

Radiology

authors

Teplick SK,Haskin PH

doi

10.1148/radiology.153.2.6484170

subject

Has Abstract

pub_date

1984-11-01 00:00:00

pages

379-83

issue

2

eissn

0033-8419

issn

1527-1315

journal_volume

153

pub_type

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