Abstract:
:Purpose To develop and demonstrate in vitro and in vivo a single interventional magnetic resonance (MR)-active device that integrates the functions of precise identification of a tissue site with the delivery of radiofrequency (RF) energy for ablation, high-spatial-resolution thermal mapping to monitor thermal dose, and quantitative MR imaging relaxometry to document ablation-induced tissue changes for characterizing ablated tissue. Materials and Methods All animal studies were approved by the institutional animal care and use committee. A loopless MR imaging antenna composed of a tuned microcable either 0.8 or 2.2 mm in diameter with an extended central conductor was switched between a 3-T MR imaging unit and an RF power source to monitor and perform RF ablation in bovine muscle and human artery samples in vitro and in rabbits in vivo. High-spatial-resolution (250-300-μm) proton resonance frequency shift MR thermometry was interleaved with ablations. Quantitative spin-lattice (T1) and spin-spin (T2) relaxation time MR imaging mapping was performed before and after ablation. These maps were compared with findings from gross tissue examination of the region of ablated tissue after MR imaging. Results High-spatial-resolution MR imaging afforded temperature mapping in less than 8 seconds for monitoring ablation temperatures in excess of 85°C delivered by the same device. This produced irreversible thermal injury and necrosis. Quantitative MR imaging relaxation time maps demonstrated up to a twofold variation in mean regional T1 and T2 after ablation versus before ablation. Conclusion A simple, integrated, minimally invasive interventional probe that provides image-guided therapy delivery, thermal mapping of dose, and detection of ablation-associated MR imaging parametric changes was developed and demonstrated. With this single-device approach, coupling-related safety concerns associated with multiple conductor approaches were avoided. © RSNA, 2016 Online supplemental material is available for this article.
journal_name
Radiologyjournal_title
Radiologyauthors
Ertürk MA,Sathyanarayana Hegde S,Bottomley PAdoi
10.1148/radiol.2016151447subject
Has Abstractpub_date
2016-12-01 00:00:00pages
927-932issue
3eissn
0033-8419issn
1527-1315journal_volume
281pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract:PURPOSE:To determine the feasibility of mapping the spatial variation of cartilage T2 relaxation time in vivo in the pediatric knee with a 1.5-T clinical magnetic resonance (MR) imaging system and the manufacturer's body gradient coil. MATERIALS AND METHODS:Twenty-five children and adolescents (age range, 5-17 years; ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2251011461
更新日期:2002-10-01 00:00:00
abstract::Gianturco expandable metallic stents were used for treating six patients with inferior vena cava (IVC) obstruction due to compression by large hepatic tumors and three patients with idiopathic obstruction of the hepatic IVC and Budd-Chiari syndrome who showed reocclusion or stenosis 3-21 months after previously perfor...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.176.3.2143840
更新日期:1990-09-01 00:00:00
abstract::Sports medicine is one of the most rapidly growing subspecialties in orthopedics. Magnetic resonance (MR) imaging in sports medicine includes depiction of normal anatomy and pathologic conditions in almost every joint in the body, but the MR examinations most frequently requested are of the knee and shoulder. The repo...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiol.2243012180
更新日期:2002-09-01 00:00:00
abstract::The National Institutes of Health (NIH) comprise the largest single source of funding in the world for the support of biomedical research. Much of the work of the NIH focuses on the elucidation of fundamental biophysical, biochemical, and biologic aspects of the molecular, cellular, and tissue processes underlying bot...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiol.2421051180
更新日期:2007-01-01 00:00:00
abstract::Two cases of adenoid cystic carcinoma of the trachea, and a review of the literature, are presented. This unusual and often undiagnosed tumor closely mimics asthma and chronic bronchitis. Although many patients die within 2 to 3 years of the onset of symptoms without appropriate treatment, adequate therapy should lead...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/122.3.597
更新日期:1977-03-01 00:00:00
abstract::Doppler sonography and magnetic resonance (MR) angiography were prospectively used in combination as a substitute for conventional angiography in 24 consecutive patients likely to undergo carotid endarterectomy. Of 19 patients (20 lesions) who underwent carotid endarterectomy, 18 had not undergone preoperative angiogr...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.186.2.8421730
更新日期:1993-02-01 00:00:00
abstract::Ventricular fibrillation thresholds were measured in anesthetized, closed-chest dogs during the injection of Renografin 76 or Conray 400 into the left coronary artery. Both agents significantly lowered fibrillation threshold--Renografin to 58 +/- 7%; Conray to 20 +/- 5% of control, respectively. The experimental metho...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/129.1.215
更新日期:1978-10-01 00:00:00
abstract:PURPOSE:To evaluate the long-term clinical and hemodynamic effectiveness of aortic stent placement in cases of failure of intended infrarenal percutaneous transluminal aortic angioplasty (PTAA). MATERIALS AND METHODS:Fifty-three patients who underwent technically successful PTAA were compared with 24 patients who unde...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.219.3.r01jn19655
更新日期:2001-06-01 00:00:00
abstract:PURPOSE:To compare various subjective, empiric, and pharmacokinetic methods for interpreting findings at dynamic magnetic resonance (MR) imaging of the breast. MATERIALS AND METHODS:Dynamic spiral breast MR imaging was performed in 52 women suspected of having or with known breast disease. Gadolinium-enhanced images w...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.209.2.9807580
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:To retrospectively assess the apparent diffusion coefficient (ADC) for prediction of malignancy and prognosis of malignant astrocytic tumors. MATERIALS AND METHODS:The institutional review board approved this study and did not require patient informed consent. Findings from 37 consecutive patients (21 men, 16 ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2413051276
更新日期:2006-12-01 00:00:00
abstract::A fluid collection within the retropubic space has a characteristic sonographic contour which, when combined with a partially distended bladder, resembles a yoke over a bell. The fluid conforms to the anterior convexity of the bladder. This configuration is distinct from that of ascites or a lymphadenectomy-related ly...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.147.1.6828730
更新日期:1983-04-01 00:00:00
abstract::When a 30-minute infusion is chosen for intravenous cholangiography, the optimal dose in subjects with normal and decreased hepatic function seems to be 0.6 ml/kg iodipamide. Delayed visualization of the ducts and gallbladder occurs in hepatic dysfunction, therefore, radiographs should be taken up to eight hours after...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/114.3.519
更新日期:1975-03-01 00:00:00
abstract::The appearance of testicular prostheses on magnetic resonance (MR) images was studied in six patients with seven silicone implants: two with a fluid consistency and five that were solid. On T1-weighted images, both types of prosthesis demonstrated homogeneous low signal intensity; on T2-weighted images, the fluid impl...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.173.2.2798890
更新日期:1989-11-01 00:00:00
abstract::The authors describe an adaptive motion correction method for three-dimensional magnetic resonance (MR) imaging. Three-dimensional imaging offers many advantages over two-dimensional multisection imaging but is susceptible to image corruption due to motion. Thus, it has been of limited use in the imaging of mobile str...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.177.1.2399320
更新日期:1990-10-01 00:00:00
abstract::Fifty-five liver metastases in 21 patients were treated with interstitial laser photocoagulation (ILP). Tumors were irradiated with a neodymium yttrium aluminum garnet laser via optical fibers passed through 19-gauge needles inserted under ultrasound (US) guidance. Heating of the tumor was evident at real-time US as a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.187.2.8475270
更新日期:1993-05-01 00:00:00
abstract::Twenty-three renal artery stenoses in 21 hypertensive patients, caused by fibromuscular dysplasia, were treated with percutaneous transluminal angioplasty (PTA). Follow-up over a period of 1 to 30 months, including angiography, renal vein renin assay, and radionuclide flow studies, was performed in 8 patients, each wi...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.143.3.6210930
更新日期:1982-06-01 00:00:00
abstract::The preangiographic diagnosis of cerebral dural arteriovenous fistula (DAVF) can be difficult. The magnetic resonance (MR) images of 12 patients with angiographically proved DAVF were evaluated to characterize the appearance of these lesions and to identify those patients at increased risk for complications. Patients ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.175.1.2315480
更新日期:1990-04-01 00:00:00
abstract:PURPOSE:To retrospectively determine if renal cell carcinoma can be differentiated from high-attenuation renal cysts at unenhanced computed tomography (CT) based on Hounsfield unit measurements and heterogeneity. MATERIALS AND METHODS:The Human Investigation Committee at our institution approved this study with waiver...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2432060559
更新日期:2007-05-01 00:00:00
abstract::Nineteen patients with unequivocal angiographic evidence of unilateral or bilateral posterior cerebral artery occulsion were scanned during the acute phase of the stroke. In 12 of them an abnormal accumulation of radioactivity was apparent on the posterior view, but only 2 also exhibited abnormal uptake on the corresp...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/123.2.393
更新日期:1977-05-01 00:00:00
abstract::Purpose To evaluate the association between Breast Imaging Reporting and Data System (BI-RADS) mammographic and magnetic resonance (MR) imaging features and breast cancer recurrence risk in patients with estrogen receptor-positive breast cancer who underwent the Oncotype DX assay. Materials and Methods In this institu...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2017162333
更新日期:2018-01-01 00:00:00
abstract::Adjuvant chemotherapy prolongs the survival of patients with high-grade osteosarcoma. Preoperative chemotherapy allows identification of effective agents for adjuvant chemotherapy based on response of the primary tumor. Preoperative determination of tumor response has therapeutic implications, and angiography offers a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.170.3.2916040
更新日期:1989-03-01 00:00:00
abstract::Adenocarcinoma of the endometrium commonly presents at an early stage and is readily diagnosed by dilatation and curettage. Ultrasound has not bee accurate in differentiating this malignant neoplasm from benign causes of uterine enlargement such as leiomyoma. In this study, the sonographic findings in 21 patients with...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.140.3.7280250
更新日期:1981-09-01 00:00:00
abstract:PURPOSE:To evaluate the accuracy of transvaginal ultrasound (US) and gadolinium-enhanced magnetic resonance (MR) imaging in the assessment of the intratumoral structure of an adnexal mass. MATERIALS AND METHODS:The population comprised 82 patients with an adnexal mass who underwent both transvaginal US and gadolinium-...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.198.1.8539360
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To determine if oxidative and nitrative stress and/or apoptosis contribute to increased coagulation when combining radiofrequency (RF) ablation with liposomal doxorubicin. MATERIALS AND METHODS:Animal care committee approval was obtained. R3230 mammary adenocarcinomas in Fischer rats were treated with either R...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.09091196
更新日期:2010-04-01 00:00:00
abstract::Cortical fissuring, a well-recognized radiographic sign of osteomyelitis, represents spread of infection through the haversian system with osteoclastic bone resorption. In the proper clinical setting this finding may be recognized before there is other evidence of bone destruction or periosteal reaction. Three cases a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.141.1.7027310
更新日期:1981-10-01 00:00:00
abstract::Gated radionuclide imaging with 99mTc-labeled red blood cells was employed to assess changes in right atrial (RA) volume in 17 subjects. Studies were repeated within two hours in five of 12 normal subjects and at two and ten days after infarction in five patients. Time-activity curves were generated for the RA and rig...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.139.3.7232740
更新日期:1981-06-01 00:00:00
abstract::Thirty-seven patients with 18 primary advanced or persistent, 16 local recurrent, and three local metastatic tumors of the head and neck were treated with a combination of interstitial low-dose iridium-192 radiation therapy and interstitial 915-MHz microwave hyperthermia supplemented by external radiation therapy. Twe...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.176.1.2353100
更新日期:1990-07-01 00:00:00
abstract::Twenty-two normal volunteers and 32 patients with either benign prostatic hypertrophy or prostatic carcinoma were examined by magnetic resonance imaging (MRI). The images were of high quality and clearly demonstrated the prostate gland and the surrounding anatomy but were of limited value in differentiating between be...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.154.1.2578070
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:To prospectively investigate the prevalence of fat deposition in chronic myocardial infarction (MI) by using magnetic resonance (MR) fat-water separation imaging with sampling of the entire left ventricular (LV) myocardium. A subsidiary aim was to determine the relationship between LV fat deposition and scar ch...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2532082290
更新日期:2009-10-01 00:00:00
abstract::The CT scan with the 160 x 160 matrix demonstrated both the normal orbital anatomy and the abnormal orbital anatomy of Graves' ophthalmopathy in great detail. In Graves' ophthalmopathy, the cardinal pathologic feature of extraocular muscle enlargement was accurately reflected on the CT scan and was a distinctive, diag...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/118.3.615
更新日期:1976-03-01 00:00:00