Modic changes on MR images as studied with provocative diskography: clinical relevance--a retrospective study of 2457 disks.

Abstract:

PURPOSE:To assess the value of vertebral body endplate signal intensity (Modic) changes on magnetic resonance (MR) images in predicting a painful disk, with provocative diskography as the reference standard. MATERIALS AND METHODS:Lumbar spine diskograms and prediskogram MR images of 736 patients (2457 disks) were retrospectively reviewed as part of an institutional review board-approved HIPAA-compliant protocol. Each disk was assigned a Modic subtype: type 0, normal; type 1, nonfatty high signal intensity; type 2, fatty; and type 3, sclerosis. Statistical analysis involved use of a 2 x 2 contingency table of diskogram results for each of the subtypes. The subtype sensitivity, specificity, positive predictive value (PPV), negative predictive value, and confidence intervals (CIs) were calculated. Similar analyses of other MR variables (such as disk herniation, high signal intensity zone, and spondylolisthesis) and type 1 signal intensity changes also were performed. RESULTS:Type 1 changes (n = 155) had a high PPV (0.81; 95% CI: 0.74, 0.87) for a provocative diskogram. Type 2 changes (n = 126) had a lower PPV (0.64; 95% CI: 0.55, 0.72) for a positive diskogram. Type 3 changes (n = 21) had a PPV (0.57; 95% CI: 0.34, 0.78) that was not significant for a positive diskogram. The PPV of an endplate with a type 1 change (hereafter, type 1 endplate) for a tear in the annulus fibrosis of the disk was also insignificant (0.14; 95% CI: 0.09, 0.20). A similar analysis between a type 1 endplate and the presence of a disk herniation (PPV, 0.26; 95% CI: 0.19, 0.34) and between a type 1 endplate and vertebral body spondylolisthesis (PPV, 0.28; 95% CI: 0.20, 0.35) were significant. CONCLUSION:Type 1 signal intensity changes on MR images have a high positive predictive value in the identification of a pain generator.

journal_name

Radiology

journal_title

Radiology

authors

Thompson KJ,Dagher AP,Eckel TS,Clark M,Reinig JW

doi

10.1148/radiol.2503080474

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

849-55

issue

3

eissn

0033-8419

issn

1527-1315

pii

250/3/849

journal_volume

250

pub_type

杂志文章
  • Benefit of independent double reading in a population-based mammography screening program.

    abstract:PURPOSE:To evaluate independent double reading in mammography screening and, specifically, the effect on breast cancer detection. MATERIALS AND METHODS:Mammographic studies of 11,343 women, aged 41-75 years, who participated in a population-based screening program were independently screened by two experienced radiolo...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.191.1.8134580

    authors: Thurfjell EL,Lernevall KA,Taube AA

    更新日期:1994-04-01 00:00:00

  • Radiographic and morphological features of cyst formation in idiopathic bone infarction.

    abstract::Cyst formation in an infarcted bone, though rare, can be diagnosed with reasonable confidence when radiographs show an expanding lytic lesion confined by an intact but attenuated cortex. If the cortex is destroyed and a periosteal response or soft-tissue mass is present, malignant transformation should be suspected. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.146.2.6849080

    authors: Norman A,Steiner GC

    更新日期:1983-02-01 00:00:00

  • Selective injection of contrast media: inflammatory effects on rabbit fallopian tubes.

    abstract::The inflammatory effects of fallopian tube catheterization and selective injection of seven contrast agents (ethiodized oil, diatrizoate meglumine 52%, diatrizoate meglumine 66%, iothalamate meglumine 60%, iopamidol, ioxitol, and ioxaglate) were evaluated in 88 rabbits. The contrast agent used was randomly selected an...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.180.1.1647040

    authors: Thurmond AS,Hedgpeth PL,Scanlan RM

    更新日期:1991-07-01 00:00:00

  • Intracranial calcification in children with osteopetrosis caused by carbonic anhydrase II deficiency.

    abstract::Radiographs of 18 children thought to have carbonic anhydrase II deficiency were reviewed to assess intracranial calcification. These children have an autosomal recessive syndrome consisting of osteopetrosis, renal tubular acidosis, intracranial calcification, and developmental retardation. This calcification is in th...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.157.2.2413500

    authors: Cumming WA,Ohlsson A

    更新日期:1985-11-01 00:00:00

  • Circular esophageal myotomy simulating a pulmonary or mediastinal pseudocyst.

    abstract::Circular esophageal myotomy of the upper pouch in infants with esophageal atresia is an effective means of reducing anastomotic tension. This report describes two patients who developed marked postoperative dilatation of the proximal esophagus at the myotomy site. On radiographs, the dilated, air-filled esophagus simu...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.136.2.7403510

    authors: Siegel MJ,Shackelford GD,McAlister WH,Bell MJ

    更新日期:1980-08-01 00:00:00

  • Mammographically detected breast cancer: location in women under 50 years old.

    abstract::The mammograms of 86 women under the age of 50 years with mammographically detected cancers were reviewed. Sixty-three of these cancers (73%) were found at the periphery of the breast as defined by a zone 1 cm wide beneath the subcutaneous fat or anterior to the retromammary fat. This finding is likely due to the geom...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.186.3.8381550

    authors: Stacey-Clear A,McCarthy KA,Hall DA,Pile-Spellman E,White G,Hulka CA,Whitman GJ,Halpern EF,Kopans DB

    更新日期:1993-03-01 00:00:00

  • Fluorescent iodized emulsion for pre- and intraoperative sentinel lymph node imaging: validation in a preclinical model.

    abstract:PURPOSE:To validate the usefulness of a newly developed tracer for preoperative gastric sentinel lymph node (LN) (SLN) mapping and intraoperative navigation after a single preoperative submucosal injection in rat and beagle models. MATERIALS AND METHODS:This study was approved by the Experimental Animal Ethical Commit...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.14141159

    authors: Kim H,Lee SK,Kim YM,Lee EH,Lim SJ,Kim SH,Yang J,Lim JS,Hyung WJ

    更新日期:2015-04-01 00:00:00

  • CT-guided Lung Biopsy: Effect of Biopsy-side Down Position on Pneumothorax and Chest Tube Placement.

    abstract::Background Supine or prone positioning of the patient on the gantry table is the current standard of care for CT-guided lung biopsy; positioning biopsy side down was hypothesized to be associated with lower pneumothorax rate. Purpose To assess the effect of positioning patients biopsy side down during CT-guided lung b...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2019182321

    authors: Drumm O,Joyce EA,de Blacam C,Gleeson T,Kavanagh J,McCarthy E,McDermott R,Beddy P

    更新日期:2019-07-01 00:00:00

  • Congenital diaphragmatic hernia diagnosed prenatally by ultrasound.

    abstract::Seven infants born at our institution between July 1979 and June 1982 had congenital diaphragmatic hernia (CDH). Four cases of CDH were correctly identified by fetal ultrasonography. Diagnosis relied upon the demonstration of abdominal organs within the thorax. During this period, no false positive diagnoses of CDH we...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.148.1.6856820

    authors: Chinn DH,Filly RA,Callen PW,Nakayama DK,Harrison MR

    更新日期:1983-07-01 00:00:00

  • Skull-base tumors: ethanol embolization of the cavernous carotid artery.

    abstract::Tumors of the skull base frequently have some blood supply from cavernous branches of the internal carotid artery (ICA). Preoperative embolization of such pedicles can expedite the subsequently performed surgery. Sometimes, however, the tumor vessels are multiple and very small so selective catheterizations are not po...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.181.3.1947090

    authors: Jungreis CA

    更新日期:1991-12-01 00:00:00

  • Tumor burden in patients with neurofibromatosis types 1 and 2 and schwannomatosis: determination on whole-body MR images.

    abstract:PURPOSE:To develop a three-dimensional (3D) segmentation and computerized volumetry technique for use in the assessment of neurofibromatosis and to assess the ability of this technique to aid in the calculation of tumor burden in patients with neurofibromatosis types 1 and 2 (NF1 and NF2, respectively) and schwannomato...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2503080700

    authors: Cai W,Kassarjian A,Bredella MA,Harris GJ,Yoshida H,Mautner VF,Wenzel R,Plotkin SR

    更新日期:2009-03-01 00:00:00

  • Osteosarcoma: angiographic assessment of response to preoperative chemotherapy.

    abstract::Adjuvant chemotherapy prolongs the survival of patients with high-grade osteosarcoma. Preoperative chemotherapy allows identification of effective agents for adjuvant chemotherapy based on response of the primary tumor. Preoperative determination of tumor response has therapeutic implications, and angiography offers a...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.170.3.2916040

    authors: Carrasco CH,Charnsangavej C,Raymond AK,Richli WR,Wallace S,Chawla SP,Ayala AG,Murray JA,Benjamin RS

    更新日期:1989-03-01 00:00:00

  • DSA versus multi-detector row CT angiography in peripheral arterial disease: randomized controlled trial.

    abstract:PURPOSE:To prospectively compare therapeutic confidence in, patient outcomes (in terms of quality of life) after, and the costs of digital subtraction angiography (DSA) with those of multi-detector row computed tomographic (CT) angiography as the initial diagnostic imaging test in patients with peripheral arterial dise...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1148/radiol.2372040616

    authors: Kock MC,Adriaensen ME,Pattynama PM,van Sambeek MR,van Urk H,Stijnen T,Hunink MG

    更新日期:2005-11-01 00:00:00

  • Gallbladder disease: appearance of associated transient increased attenuation in the liver at biphasic, contrast-enhanced dynamic CT.

    abstract:PURPOSE:To evaluate the frequency, location, and appearance of transient increased attenuation in the liver during arterial-phase helical or incremental computed tomography (CT) in patients with gallbladder disease without hepatic extension. MATERIALS AND METHODS:Findings in dynamic CT examinations in 31 patients with...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.204.3.9280250

    authors: Ito K,Awaya H,Mitchell DG,Honjo K,Fujita T,Uchisako H,Moritani K,Nomura S,Higuchi M,Kada T,Matsumoto T,Matsunaga N

    更新日期:1997-09-01 00:00:00

  • Therapeutic embolization: enhanced radiolabeled monitoring.

    abstract::Radiolabeling of Ivalon (polyvinyl alcohol sponge) particles permits localization of injected particles during embolization through the use of a portable gamma camera and provides a means to prevent potentially fatal complications such as pulmonary embolization. A more efficient technique of labeling Ivalon particles ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.177.2.2217800

    authors: duCret RP,Adkins MC,Hunter DW,Yedlicka JW,Engeler CM,Castaneda-Zuniga WR,Amplatz K,Sirr SA,Boudreau RJ,Kuni CC

    更新日期:1990-11-01 00:00:00

  • Assessment of bone marrow angiogenesis in patients with acute myeloid leukemia by using contrast-enhanced MR imaging with clinically approved iron oxides: initial experience.

    abstract:PURPOSE:To prospectively assess bone marrow (BM) angiogenesis in patients with acute myeloid leukemia (AML) by using iron oxide-enhanced magnetic resonance (MR) imaging. MATERIALS AND METHODS:The study was institutional ethics committee approved. Informed signed consent was obtained from each study participant. The re...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2421051355

    authors: Matuszewski L,Persigehl T,Wall A,Meier N,Bieker R,Kooijman H,Tombach B,Mesters R,Berdel WE,Heindel W,Bremer C

    更新日期:2007-01-01 00:00:00

  • MR Imaging of Brachial Plexus and Limb-Girdle Muscles in Patients with Amyotrophic Lateral Sclerosis.

    abstract:PURPOSE:To assess brachial plexus magnetic resonance (MR) imaging features and limb-girdle muscle abnormalities as signs of muscle denervation in patients with amyotrophic lateral sclerosis (ALS). MATERIALS AND METHODS:This study was approved by the local ethical committees on human studies, and written informed conse...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2015150559

    authors: Gerevini S,Agosta F,Riva N,Spinelli EG,Pagani E,Caliendo G,Chaabane L,Copetti M,Quattrini A,Comi G,Falini A,Filippi M

    更新日期:2016-05-01 00:00:00

  • Adenocarcinoma of the esophagus: relationship to Barrett mucosa.

    abstract::Primary adenocarcinoma of the esophagus is thought to be a rare lesion. However, pathologic records at our institution from 1979 to 1982 show that adenocarcinoma accounted for 17 of 89 (19%) of all primary malignant tumors in the esophagus. All 17 cases arose in Barrett mucosa. In eight cases, there was surgically pro...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.150.2.6691080

    authors: Levine MS,Caroline D,Thompson JJ,Kressel HY,Laufer I,Herlinger H

    更新日期:1984-02-01 00:00:00

  • Intravenous cholangiography in normal and subsequently liver-damaged dogs.

    abstract::When a 30-minute infusion is chosen for intravenous cholangiography, the optimal dose in subjects with normal and decreased hepatic function seems to be 0.6 ml/kg iodipamide. Delayed visualization of the ducts and gallbladder occurs in hepatic dysfunction, therefore, radiographs should be taken up to eight hours after...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/114.3.519

    authors: Burgener FA,Fischer HW

    更新日期:1975-03-01 00:00:00

  • Global small bowel motility: assessment with dynamic MR imaging.

    abstract:PURPOSE:To assess the repeatability in human volunteers of software-quantified small bowel motility captured with magnetic resonance (MR) imaging and to test the ability to detect changes in motility induced by pharmacologic agents. MATERIALS AND METHODS:The study was approved by the Royal Free Research Ethics Committ...

    journal_title:Radiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1148/radiol.13130151

    authors: Menys A,Taylor SA,Emmanuel A,Ahmed A,Plumb AA,Odille F,Alam A,Halligan S,Atkinson D

    更新日期:2013-11-01 00:00:00

  • CT use in hospitalized pediatric trauma patients: 15-year trends in a level I pediatric and adult trauma center.

    abstract:PURPOSE:To evaluate the 15-year trend in the use of computed tomography (CT) in hospitalized pediatric trauma patients admitted to Harborview Medical Center (HMC) from 1996 to 2010. MATERIALS AND METHODS:This Health Insurance Portability and Accountability Act-compliant retrospective study was approved by the institut...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.13120865

    authors: Roudsari BS,Psoter KJ,Vavilala MS,Mack CD,Jarvik JG

    更新日期:2013-05-01 00:00:00

  • CT of thrombosed arteriovenous malformations in children.

    abstract::Thrombosed arteriovenous malformations (AVMs) in children are rare lesions that may present with headaches or a seizure disorder. Thirteen patients (4 months to 21 years of age) with this lesion were examined with computed tomography (CT). In 11 patients surgical confirmation was obtained, and the other two patients w...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.150.2.6691090

    authors: Mitnick JS,Pinto RS,Lin JP,Rose H,Lieberman A

    更新日期:1984-02-01 00:00:00

  • US-guided fallopian tube catheterization.

    abstract::Ultrasound-guided fallopian tube catheterization was performed in seven women a total of 14 times. The women had normal-appearing fallopian tubes at hysterosalpingography and received sperm via the catheter as a way to overcome their inability to conceive. Techniques similar to those used for fluoroscopically guided f...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.180.2.2068330

    authors: Thurmond AS,Patton PE,Hector DM,Jones MK

    更新日期:1991-08-01 00:00:00

  • Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings.

    abstract:PURPOSE:To evaluate the safety and efficacy of gadoxetic acid disodium-enhanced magnetic resonance (MR) imaging for the detection of focal liver lesions, with results of histopathologic examination and/or intraoperative ultrasonography used as a standard of reference. MATERIALS AND METHODS:One hundred sixty-nine patie...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1148/radiol.2301020269

    authors: Huppertz A,Balzer T,Blakeborough A,Breuer J,Giovagnoni A,Heinz-Peer G,Laniado M,Manfredi RM,Mathieu DG,Mueller D,Reimer P,Robinson PJ,Strotzer M,Taupitz M,Vogl TJ,European EOB Study Group.

    更新日期:2004-01-01 00:00:00

  • Extramedullary plasmacytoma.

    abstract::Extramedullary plasmacytoma is a rare form of plasma cell dyscrasia, in which malignant plasma cell tumors arise outside the bone marrow. The tumor may arise in any part of the body but the vast majority occur in the head and neck, primarily in the nasal cavity, paranasal sinuses, or upper airway. Six patients with ex...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/128.3.625

    authors: Schabel SI,Rogers CI,Rittenberg GM,Bubanj R

    更新日期:1978-09-01 00:00:00

  • Interstitial lung disease: impact of postprocessing in digital storage phosphor imaging.

    abstract::The ability to resolve the fine linear structures of interstitial lung disease is one measure of the limiting performance characteristics of an imaging system. Conventional screen-film radiography was compared with six algorithms of isodose storage phosphor digital radiography (0.2-mm x 10-bit pixel matrix) in the det...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.178.3.1994410

    authors: Schaefer CM,Greene R,Llewellyn HJ,Mrose HE,Pile-Spellman EA,Rubens JR,Lindemann SR

    更新日期:1991-03-01 00:00:00

  • Validation of quantitative analysis of multiparametric prostate MR images for prostate cancer detection and aggressiveness assessment: a cross-imager study.

    abstract:PURPOSE:To validate three previously identified quantitative image features across multiparametric magnetic resonance (MR) images acquired with imagers made by two different manufacturers to differentiate prostate cancer (PC) from normal prostatic tissue and to assess cancer aggressiveness. MATERIALS AND METHODS:This ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.14131320

    authors: Peng Y,Jiang Y,Antic T,Giger ML,Eggener SE,Oto A

    更新日期:2014-05-01 00:00:00

  • Thrombolytic therapy with recombinant human tissue-type plasminogen activator: a comparison of two doses.

    abstract::The efficacy and safety of two doses of recombinant human tissue-type plasminogen activator (rt-PA) were compared. Forty patients with peripheral arterial occlusions were treated with intraarterial rt-PA. Group A (n = 21) received 0.1 mg/kg/h, and group B (n = 19) received 0.05 mg/kg/h. Infusion durations varied from ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.164.2.3110860

    authors: Risius B,Graor RA,Geisinger MA,Zelch MG,Lucas FV,Young JR

    更新日期:1987-08-01 00:00:00

  • Recurrent rectal cancer: diagnosis with dynamic MR imaging.

    abstract:PURPOSE:To evaluate whether dynamic magnetic resonance (MR) imaging can increase the diagnostic accuracy in suspected local recurrence of rectal carcinoma. MATERIALS AND METHODS:Eighteen patients (seven men, 11 women, aged 26-78 years) with 19 suspect lesions were examined. T1-weighted (pre- and postcontrast) and T2-w...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.189.3.8234720

    authors: Müller-Schimpfle M,Brix G,Layer G,Schlag P,Engenhart R,Frohmuller S,Hess T,Zuna I,Semmler W,van Kaick G

    更新日期:1993-12-01 00:00:00

  • Preoperative detection and localization of accessory pudendal artery with contrast-enhanced MR angiography.

    abstract:PURPOSE:To evaluate the diagnostic performance of contrast material-enhanced magnetic resonance (MR) angiography for preoperative detection and localization of accessory pudendal arteries (APAs) in patients with prostate cancer. MATERIALS AND METHODS:This prospective study was approved by the institutional review boar...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11110934

    authors: Whang SY,Sung DJ,Lee SA,Park BJ,Kim MJ,Cho SB,Kim YH,Cheon J

    更新日期:2012-03-01 00:00:00