Abstract:
PURPOSE:To determine if T2 relaxation time measurements with magnetic resonance (MR) imaging in patients with Graves ophthalmopathy (GO) can predict response to therapy. MATERIALS AND METHODS:Studied were 84 patients with GO, 27 with Graves disease without ophthalmopathy (GD), and 12 control subjects without Graves disease. T2 times of extraocular muscles and retrobulbar fat tissue were measured. Twenty-five patients with GO were treated with systemic corticosteroids and retroorbital radiation therapy. RESULTS:T2 relaxation times of muscles in patients with GD were the same as those in controls but were longer in patients with GO (P < .05). T2 times of fat in all patients were the same as those of the controls. The predicted probability of response to treatment increased with increased mean T2 relaxation times of extraocular muscles prior to therapy. Of the 25 patients with combined therapy, only those with particularly prolonged T2 relaxation times showed impressive response. CONCLUSIONS:T2 relaxation time measurements with MR allow noninvasive detection of acute muscle inflammation and predict which patients with GO will likely benefit from antiinflammatory therapy.
journal_name
Radiologyjournal_title
Radiologyauthors
Ohnishi T,Noguchi S,Murakami N,Tajiri J,Harao M,Kawamoto H,Hoshi H,Jinnouchi S,Futami S,Nagamachi Sdoi
10.1148/radiology.190.3.8115640subject
Has Abstract,Author List Incompletepub_date
1994-03-01 00:00:00pages
857-62issue
3eissn
0033-8419issn
1527-1315journal_volume
190pub_type
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