Juvenile nasopharyngeal angiofibroma: efficacy of radiation therapy.

Abstract:

:From 1962 to 1984, 13 patients with juvenile nasopharyngeal angiofibroma (JNA) were treated with megavoltage radiation therapy. Follow-up ranged from 40 to 255 months (median, 136 months). Two patients received radiation therapy as the initial treatment; the other 11 patients had undergone unsuccessful previous surgical treatment (median, three resections). Gross tumor was evident at the start of radiation therapy in seven patients, and orbital, sphenoid sinus, or intracranial extension was noted in eight of 13 (62%). Doses ranged from 3,600 to 5,200 cGy (median, 4,800 cGy in daily fractions of 180-200 cGy). Tumor was controlled in 11 patients (85%) after irradiation. Two patients were treated with embolization for residual mass; both remained asymptomatic and without evidence of tumor 134 and 83 months after embolization, respectively. With the exception of xerostomia and caries, no significant chronic morbidity was seen. This review and other studies demonstrate that megavoltage radiation therapy is an effective and appropriate treatment for advanced and recurrent JNA; its routine use for early tumors remains controversial.

journal_name

Radiology

journal_title

Radiology

authors

Fields JN,Halverson KJ,Devineni VR,Simpson JR,Perez CA

doi

10.1148/radiology.176.1.2162070

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

263-5

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

176

pub_type

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