Abstract:
PURPOSE:To develop a method to assess volumetric cortical bone porosity in clinically practical acquisition times by measuring the signal decay at only two echo times (TEs) as part of a single three-dimensional ultrashort TE (UTE) magnetic resonance (MR) examination. MATERIALS AND METHODS:The study was approved by the institutional review board and complied with HIPAA guidelines. Written informed consent was obtained from all subjects. A marker of cortical bone porosity called porosity index was defined as the ratio of UTE image intensities at a long and short TE, and the results were compared with biexponential analysis. Porosity index of midtibia cortical bone samples obtained from 16 donors was compared with ground-truth porosity by using micro-computed tomographic (CT) imaging and bone mineral density by peripheral quantitative CT scanner. Reproducibility of porosity index were tested in volunteers, and clinical feasibility was evaluated in postmenopausal women. Interparameter associations were assessed by using Pearson or Spearman correlation coefficient. RESULTS:Bone specimen porosity index was correlated with micro-CT imaging porosity (R(2) = 0.79) and pore size (R(2) = 0.81); age (R(2) = 0.64); peripheral quantitative CT scanner density (R(2) = 0.49, negatively); and pore water fraction (R(2) = 0.62) and T2* (R(2) = 0.64) by biexponential analysis. The reproducibility study yielded a coefficient of variation of 2.2% and intraclass correlation coefficient of 0.97. The study that involved postmenopausal women showed a wide range of porosity index (15%-38%). CONCLUSION:A two-point MR imaging method to assess cortical bone porosity in humans was conceived and validated. This approach has the potential for clinical use to assess changes in cortical bone porosity that result from disease or in response to therapy. (©) RSNA, 2015 Online supplemental material is available for this article.
journal_name
Radiologyjournal_title
Radiologyauthors
Rajapakse CS,Bashoor-Zadeh M,Li C,Sun W,Wright AC,Wehrli FWdoi
10.1148/radiol.15141850subject
Has Abstractpub_date
2015-08-01 00:00:00pages
526-35issue
2eissn
0033-8419issn
1527-1315journal_volume
276pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract:PURPOSE:To evaluate the feasibility of magnetic resonance (MR) imaging-guided placement of an active vena cava filter (AVCF) in a swine model, the effectiveness of the system in filtering thrombi, and the detection of thrombi with MR imaging. MATERIALS AND METHODS:This study was approved by the government committee on...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.10092487
更新日期:2011-02-01 00:00:00
abstract::A patient with jaundice caused by obstruction of the biliary ducts by cysts in a polycystic liver is presented. Decompression of the liver cysts under ultrasound guidance resulted in a rapid decrease of the serum bilirubin level. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.136.2.7403520
更新日期:1980-08-01 00:00:00
abstract::Transrectal sonography of the normal prostate demonstrates a gland that has low-level homogeneous echoes. Benign and malignant prostatic disease causes disruption of this normal texture. A prospective study was performed to determine the ability of ultrasound to detect focal defects accurately. The specific histologic...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.149.1.6193560
更新日期:1983-10-01 00:00:00
abstract::Four new cases of scimitar syndrome illustrate the complex derangement of the right lung architecture. Computed tomography (CT) helped in demonstrating the hyparterial relationship of the right bronchus to the pulmonary artery, the course and termination of the scimitar vein, the mediastinal shift, unusual fissures, a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.159.1.3952300
更新日期:1986-04-01 00:00:00
abstract:PURPOSE:To prospectively assess the frequency and cause of disagreements in diagnoses at ultrasonography (US) and magnetic resonance (MR) imaging for fetuses referred for ventriculomegaly (VM). MATERIALS AND METHODS:One hundred ninety-five women, aged 18-44 years, with 200 fetal referrals for VM, were recruited in a p...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2472071067
更新日期:2008-05-01 00:00:00
abstract::Quantitative microstructural sonography differs from conventional sonography in several ways. The frequency as well as the amplitude of echoes is recorded and assessed using spectral analysis techniques. The effects of diffraction of the ultrasound beam are calibrated, as are the transfer characteristics of the system...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.155.2.2984720
更新日期:1985-05-01 00:00:00
abstract::Extracranial applications of diffusion-weighted (DW) magnetic resonance (MR) imaging are gaining increasing importance, including in head and neck radiology. The main indications for performing DW imaging in this relatively small but challenging region of the body are tissue characterization, nodal staging, therapy mo...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiol.11101821
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To identify the complications and imaging findings related to lymphangioleiomyomatosis (LAM) after lung transplantation. MATERIALS AND METHODS:The authors retrospectively reviewed the clinical histories and imaging studies of 13 patients from five major medical centers who underwent unilateral (n = 8) or bilat...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.210.2.r99fe11325
更新日期:1999-02-01 00:00:00
abstract:PURPOSE:To determine whether adrenal adenomas can be differentiated from metastases on fat-saturated magnetic resonance (MR) images. MATERIALS AND METHODS:Twenty-eight adrenal adenomas and 20 metastatic lesions were imaged at 1.5 T by means of fat-saturated T1- and T2-weighted and gadolinium-enhanced T1-weighted seque...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.193.1.8090900
更新日期:1994-10-01 00:00:00
abstract::Various whole-body, multiple-field, electron-beam therapy techniques are analyzed. Accelerator characteristics, various dosimetric techniques, and experimental setup are described. A flattening filter was constructed which produced an uncollimated electron-beam profile (4 MeV) with a uniformity of +/- 8% across a 200-...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/122.1.219
更新日期:1977-01-01 00:00:00
abstract::Arthropathy is part of the protean manifestations of Behçet disease. Imaging findings reported thus far have been based on those of conventional radiography. Magnetic resonance imaging in two cases of Behçet disease with arthropathy demonstrated synovial thickening and effusion, as well as myositis manifested by high ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2262011982
更新日期:2003-02-01 00:00:00
abstract::Background Cardiac MRI late gadolinium enhancement (LGE) scar volume is an important marker for outcome prediction in patients with hypertrophic cardiomyopathy (HCM); however, its clinical application is hindered by a lack of measurement standardization. Purpose To develop and evaluate a three-dimensional (3D) convolu...
journal_title:Radiology
pub_type: 杂志文章,多中心研究
doi:10.1148/radiol.2019190737
更新日期:2020-01-01 00:00:00
abstract::In his overview of the history and theoretical developments of radiotherapy, the author stresses the following concepts: (a) sensitivity is not linked to histology but to the volume of cancer; (b) the dose must not necessarily be homogeneous in the target volume but related to varying volumes of cancer; (c) the fact t...
journal_title:Radiology
pub_type: 历史文章,杂志文章,评审
doi:10.1148/127.1.3
更新日期:1978-04-01 00:00:00
abstract::This description of procedures in two patients illustrates successful thoracic needle biopsy, despite the fact that the lesion was obscured by overlapping bones in each instance. The technique of screwing a 20-gauge needle through the overlapping bone is suggested as an innovative method when more traditional approach...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.177.1.2399330
更新日期:1990-10-01 00:00:00
abstract::Review of hospital charts of 168 patients surviving two or more years following the diagnosis of cancer and subsequent-examinations of 40 of these patients yielded these observations: (a) Hospital charts were adequate to ascertain the number of second primary neoplasms. Three malignant and eight benign tumors were fou...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/114.1.175
更新日期:1975-01-01 00:00:00
abstract::Positron emission tomography (PET) provides metabolic information that has been documented to be useful in patient care. The properties of positron decay permit accurate imaging of the distribution of positron-emitting radiopharmaceuticals. The wide array of positron-emitting radiopharmaceuticals has been used to char...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiol.2312021185
更新日期:2004-05-01 00:00:00
abstract::Computed tomographic brain scans of the newborn exhibit relatively greater lucency of white matter compared to the mature patient. This study correlated the x-ray attenuation of white matter with gestational age in 23 neonates, both premature and term. The gray-white matter attenuation difference was calculated and pl...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.139.1.7208910
更新日期:1981-04-01 00:00:00
abstract::Multicenter, collaborative studies offer an effective way to meet the growing need for timely and generalizable clinical evaluations of imaging technologies. This article discusses issues of study design, statistical analysis, organization, and day-to-day group operation for collaborative prospective clinical evaluati...
journal_title:Radiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1148/radiology.175.2.2183290
更新日期:1990-05-01 00:00:00
abstract::Magnetic resonance (MR) imaging was performed in 17 patients, 11-84 years of age, referred for evaluation of possible osteomyelitis involving the appendicular skeleton. MR imaging permitted successful identification of osteomyelitis in ten patients (four acute, two subacute with Brodie abscess, two chronic, and two ac...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.166.1.3336680
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:To characterize the magnetic resonance (MR) imaging response of brain metastases after gamma knife stereotactic radiosurgery and determine whether imaging features and tumor response rates correlate with local tumor control and survival. MATERIALS AND METHODS:Serial MR examinations were performed in 48 patient...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.211.3.r99jn48807
更新日期:1999-06-01 00:00:00
abstract::Background Chest CT is used in the diagnosis of coronavirus disease 2019 (COVID-19) and is an important complement to reverse-transcription polymerase chain reaction (RT-PCR) tests. Purpose To investigate the diagnostic value and consistency of chest CT as compared with RT-PCR assay in COVID-19. Materials and Methods ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2020200642
更新日期:2020-08-01 00:00:00
abstract::The authors describe their experience with methyl tertiary butyl ether (MTBE) in a larger series of patients than previously reported in order to acquaint physicians with both its effectiveness for dissolution of common bile duct calculi and the limitations of its use. Ten patients with 13 biliary calculi underwent pe...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.166.3.3340760
更新日期:1988-03-01 00:00:00
abstract::The small digital computer is becoming ever more powerful, reliable, and inexpensive. Diagnostic radiology and the computer are becoming more intertwined. During the past decade, computed tomography (CT) has achieved outstanding success. CT and other digital image systems that are capable of computer manipulation, sto...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.145.2.7134470
更新日期:1982-11-01 00:00:00
abstract:PURPOSE:To prospectively compare accuracy of dynamic contrast material-enhanced thin-section multi-detector row helical computed tomography (CT), high-spatial-resolution three-dimensional (3D) dynamic gadolinium-enhanced magnetic resonance (MR) imaging, and superparamagnetic iron oxide (SPIO)-enhanced MR imaging with o...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2371041444
更新日期:2005-10-01 00:00:00
abstract::While invasive imaging techniques, especially selective conventional coronary angiography, will remain vital to planning and guiding catheter-based and surgical treatment of significantly stenotic coronary lesions, the comprehensive and serial assessment of asymptomatic or minimally symptomatic stages of coronary arte...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiol.2321021803
更新日期:2004-07-01 00:00:00
abstract::Percutaneous transperitoneal fine-needle lymph-node biopsy was performed in 52 patients to establish a diagnosis of metastatic disease in nodal defects detected during lymphography. The procedure was found to be highly accurate, with few false-negatives and no false-positives. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/131.3.647
更新日期:1979-06-01 00:00:00
abstract::Sixteen cases of histopathologically proved solitary rectal ulcer syndrome were encountered. Fifteen patients underwent barium enema study; in nine cases the findings--including rectal stricture, granularity of the mucosa, and thickened rectal folds-were nonspecific. In six cases the study was normal. All patients had...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.168.2.3393650
更新日期:1988-08-01 00:00:00
abstract:PURPOSE:To measure the mean diffusional age-related changes of the brain over the full human life span by using diffusion-weighted spin-echo single-shot echo-planar magnetic resonance (MR) imaging and sequential whole-brain apparent diffusion coefficient (ADC) histogram analysis and, secondarily, to build mathematical ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.12112420
更新日期:2013-02-01 00:00:00
abstract::Radiologists are frequently called upon to perform percutaneous biopsy. Selection of the proper needle is becoming more complex as the number of types increases and reports of better results with certain needles proliferate. The authors evaluated a wide variety of needles of different caliber, cutting tip, and bevel. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.148.3.6878680
更新日期:1983-09-01 00:00:00
abstract::Magnetic resonance (MR) images of the hips and knees of three healthy volunteers were reviewed and compared with images obtained from the hips of three patients with effusions. Comparison was also made with MR images obtained from two swine knees following the injections of saline in one and blood in the other. The an...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.158.1.3940370
更新日期:1986-01-01 00:00:00