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Novel therapy for Alzheimer's disease.

Abstract：

:Recent results support the hypothesis that microglia and/or macrophages of the brain, by producing oxidants, could play a role in the local inactivation of the Kunitz protease inhibitor (KPI) domain of beta-amyloid precursor protein (APP), thereby facilitating deposition of abnormal amyloid filaments in patients with Alzheimer's disease (AD). Protease inhibitors and/or free radical scavengers might serve as therapy for the amyloidosis of AD.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

DeFeudis FV

doi

10.1016/0197-4580(89)90099-7

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

467-8; discussion 477-8

issue

5

eissn

0197-4580

issn

1558-1497

pii

0197-4580(89)90099-7

journal_volume

10

pub_type

杂志文章

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