Abstract:
INTRODUCTION:The aim of this study was to assess age- and gender-specific incidence rates (IRs) of acetylcholine receptor (AChR)-antibody-positive myasthenia gravis (MG) in South Africa, and geographical variations in incidence. METHODS:IRs were calculated from positive AChR-antibody laboratory data between 2011 and 2012, using 2011 population census data. RESULTS:890 individuals were seropositive, for an annual IR of 8.5 per million. Age-standardized IR for early-onset (<50) and late-onset (≥50) MG were 4.1 and 24 per million, respectively, and 4.3 per million for juveniles. The IR between provinces ranged from 1 to 19 per million. CONCLUSIONS:In this Southern Hemisphere African population, the overall IR and peak IR (in older men) for seropositive MG is comparable to that in Europe and North America, arguing against environmental factors. However, IRs may be higher among children with African genetic ancestry. Geographical variation in incidence underscores the importance of outreach programs for regions with limited resources.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Mombaur B,Lesosky MR,Liebenberg L,Vreede H,Heckmann JMdoi
10.1002/mus.24348subject
Has Abstractpub_date
2015-04-01 00:00:00pages
533-7issue
4eissn
0148-639Xissn
1097-4598journal_volume
51pub_type
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