Abstract:
:Circular RNA transcripts were first identified in the early 1990s but knowledge of these species has remained limited, as their study through traditional methods of RNA analysis has been difficult. Now, novel bioinformatic approaches coupled with biochemical enrichment strategies and deep sequencing have allowed comprehensive studies of circular RNA species. Recent studies have revealed thousands of endogenous circular RNAs in mammalian cells, some of which are highly abundant and evolutionarily conserved. Evidence is emerging that some circRNAs might regulate microRNA (miRNA) function, and roles in transcriptional control have also been suggested. Therefore, study of this class of noncoding RNAs has potential implications for therapeutic and research applications. We believe the key future challenge for the field will be to understand the regulation and function of these unusual molecules.
journal_name
Nat Biotechnoljournal_title
Nature biotechnologyauthors
Jeck WR,Sharpless NEdoi
10.1038/nbt.2890subject
Has Abstractpub_date
2014-05-01 00:00:00pages
453-61issue
5eissn
1087-0156issn
1546-1696pii
nbt.2890journal_volume
32pub_type
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更新日期:2011-12-11 00:00:00
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pub_type: 杂志文章,已发布勘误
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更新日期:1996-03-01 00:00:00
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更新日期:2010-04-01 00:00:00
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更新日期:2013-07-01 00:00:00
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