Retention mechanisms for ER and Golgi membrane proteins.

Abstract:

:Unless there are mechanisms to selectively retain membrane proteins in the endoplasmic reticulum (ER) or in the Golgi apparatus, they automatically proceed downstream to the plasma or vacuole membranes. Two types of coat protein complex I (COPI)-interacting motifs in the cytosolic tails of membrane proteins seem to facilitate membrane retention in the early secretory pathway of plants: a dilysine (KKXX) motif (which is typical of p24 proteins) for the ER and a KXE/D motif (which occurs in the Arabidopsis endomembrane protein EMP12) for the Golgi apparatus. The KXE/D motif is highly conserved in all eukaryotic EMPs and is additionally present in hundreds of other proteins of unknown subcellular localization and function. This novel signal may represent a new general mechanism for Golgi targeting and the retention of polytopic integral membrane proteins.

journal_name

Trends Plant Sci

journal_title

Trends in plant science

authors

Gao C,Cai Y,Wang Y,Kang BH,Aniento F,Robinson DG,Jiang L

doi

10.1016/j.tplants.2014.04.004

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

508-15

issue

8

eissn

1360-1385

issn

1878-4372

pii

S1360-1385(14)00093-4

journal_volume

19

pub_type

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