Abstract:
:Plant-derived pharmaceuticals are poised to become the next major commercial development in biotechnology. The advantages they offer in terms of production scale and economy, product safety, ease of storage and distribution cannot be matched by any current commercial system; they also provide the most promising opportunity to supply low-cost drugs and vaccines to the developing world. However, despite the promised benefits, the commercialization of plant-derived pharmaceutical products is overshadowed by the uncertain regulatory terrain, particularly with regard to the adaptation of good manufacturing practice regulations to field-grown plants. The success of such products also depends on careful negotiation of the intellectual property landscape, particularly the achievement of freedom-to-operate licenses for use in developing countries.
journal_name
Trends Plant Scijournal_title
Trends in plant scienceauthors
Ma JK,Chikwamba R,Sparrow P,Fischer R,Mahoney R,Twyman RMdoi
10.1016/j.tplants.2005.10.009subject
Has Abstractpub_date
2005-12-01 00:00:00pages
580-5issue
12eissn
1360-1385issn
1878-4372pii
S1360-1385(05)00260-8journal_volume
10pub_type
杂志文章,评审abstract::MicroProteins (miPs) are short, usually single-domain proteins that, in analogy to miRNAs, heterodimerize with their targets and exert a dominant-negative effect. Recent bioinformatic attempts to identify miPs have resulted in a list of potential miPs, many of which lack the defining characteristics of a miP. In this ...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2015.05.011
更新日期:2015-08-01 00:00:00
abstract::Distribution patterns and finely-tuned concentration gradients of plant hormones govern plant growth and development. Gibberellin (GA) is a plant hormone regulating key processes in plants; many of them are of significant agricultural importance, such as seed germination, root and shoot elongation, flowering, and frui...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2018.02.005
更新日期:2018-05-01 00:00:00
abstract::Laser-assisted microdissection (LAM) is a powerful tool for isolating specific tissues, cell types and even organelles from sectioned biological specimen in a manner conducive to the extraction of RNA, DNA or protein. LAM, which is an established technique in many areas of biology, has now been successfully adapted fo...
journal_title:Trends in plant science
pub_type: 杂志文章
doi:10.1016/j.tplants.2005.06.006
更新日期:2005-08-01 00:00:00
abstract::Vacuoles receive their proteins through the secretory pathway, this requires protein sorting signals and molecular machineries that, until recently, have been believed to be markedly distinct for lytic and storage vacuoles. However, new biochemical, morphological and genetic data indicate that the only known class of ...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2005.05.001
更新日期:2005-07-01 00:00:00
abstract::The plant-specific LBD (Lateral Organ Boundaries Domain) gene family is essential in the regulation of plant lateral organ development and is involved in the regulation of anthocyanin and nitrogen metabolism. LBD proteins contain a characteristic LOB domain composed of a C-motif required for DNA-binding, a conserved g...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2010.09.009
更新日期:2011-01-01 00:00:00
abstract::Chloroplasts have a dynamic protein environment and, although proteases are presumably major contributors, the identities of these crucial regulatory proteins have only recently been revealed. There are defined proteases within each of the major chloroplast compartments: the ATP-dependent Clp and FtsH proteases in the...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/s1360-1385(02)02326-9
更新日期:2002-10-01 00:00:00
abstract::Plants employ multiple layers of innate immunity to fight pathogens. For both RNA and DNA viruses, RNA silencing plays a critical role in plant resistance. To escape this antiviral silencing-based immune response, viruses have evolved various counterdefense strategies, the most widespread being production of viral sup...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2013.04.001
更新日期:2013-07-01 00:00:00
abstract::There is a misconception among plant scientists that osmosis is driven by the tendency of solutes to dilute water. In this opinion article, we discuss the quantitative and qualitative failures of this view, and go on to review the correct kinetic picture of osmosis as it appears in physics textbooks. ...
journal_title:Trends in plant science
pub_type: 杂志文章
doi:10.1016/j.tplants.2012.12.001
更新日期:2013-04-01 00:00:00
abstract::Stem cells are the precursors of differentiated cells and are, thus, indispensable for growth and development in plants and animals. Stem cells from both types of organisms share the fundamental features of a capacity for self-renewal and an ability to generate differentiated cells. The maintenance of stem cells in bo...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2006.03.004
更新日期:2006-05-01 00:00:00
abstract::Many agronomically important traits are governed by several genes known as quantitative trait loci (QTLs). The identification of important, QTL-controlled agricultural traits has been difficult because of their complex inheritance; however, completion of the rice genomic sequence has facilitated the cloning of QTLs an...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2006.05.008
更新日期:2006-07-01 00:00:00
abstract::Although abundant in soils, iron (Fe) is poorly bioavailable for plants. Improving Fe uptake in crops, enabling them to grow in Fe-depleted soils, has become a major focal interest. The secretion of Fe-mobilizing coumarins by plant roots recently emerged as an important factor allowing nongrass species to cope with lo...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2020.10.008
更新日期:2020-11-25 00:00:00
abstract::The Waxy (Wx) gene that governs amylose synthesis is an old but widely used target in improving the quality of starchy crops. New genome-editing strategies are being deployed to create beneficial Wx alleles with finely tuned amylose content (AC). Precise targeting must be combined with traditional approaches to develo...
journal_title:Trends in plant science
pub_type: 杂志文章
doi:10.1016/j.tplants.2020.07.009
更新日期:2020-10-01 00:00:00
abstract::Reactive oxygen species (ROS)- and calcium- dependent signaling pathways play well-established roles during plant innate immunity. Chloroplasts host major biosynthetic pathways and have central roles in energy production, redox homeostasis, and retrograde signaling. However, the organelle's importance in immunity has ...
journal_title:Trends in plant science
pub_type: 杂志文章
doi:10.1016/j.tplants.2014.10.002
更新日期:2015-01-01 00:00:00
abstract::Chloroplast genomes defied the laws of Mendelian inheritance at the dawn of plant genetics, and continue to defy the mainstream approach to biotechnology, leading the field in an environmentally friendly direction. Recent success in engineering the chloroplast genome for resistance to herbicides, insects, disease and ...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/s1360-1385(01)02193-8
更新日期:2002-02-01 00:00:00
abstract::The aluminium cation Al(3+) is toxic to many plants at micromolar concentrations. A range of plant species has evolved mechanisms that enable them to grow on acid soils where toxic concentrations of Al(3+) can limit plant growth. Organic acids play a central role in these aluminium tolerance mechanisms. Some plants de...
journal_title:Trends in plant science
pub_type: 杂志文章
doi:10.1016/s1360-1385(01)01961-6
更新日期:2001-06-01 00:00:00
abstract::To understand Ca2+ signaling, we need to identify all the Ca2+ transporters and their regulatory components. The first Ca2+ transporters to be cloned from plants and shown to have regulated activity were calmodulin-dependent Ca2+ -pumps. The regulation of these pumps suggests that being able to change the rate of Ca2+...
journal_title:Trends in plant science
pub_type: 新闻
doi:10.1016/s1360-1385(01)02023-4
更新日期:2001-09-01 00:00:00
abstract::Plant water isotopic compositions are widely used to describe patterns of soils water uptake. Although valuable, the technique only provides relative uptake distributions, which can be misleading. Without information on total transpiration, the technique cannot address central questions on drought response, competitio...
journal_title:Trends in plant science
pub_type: 杂志文章
doi:10.1016/j.tplants.2020.12.013
更新日期:2021-01-13 00:00:00
abstract::Agrobacterium tumefaciens is the preferred method for transformation of a wide range of plant species. Commonly, the genes to be transferred are cloned between the left and right T-DNA borders of so-called binary T-DNA vectors that can replicate both in E. coli and Agrobacterium. Because these vectors are generally la...
journal_title:Trends in plant science
pub_type: 杂志文章
doi:10.1016/s1360-1385(02)02251-3
更新日期:2002-05-01 00:00:00
abstract::Recent studies indicate that a multitude of microbial processes are involved in nitric oxide production and consumptions in the pedosphere. Due to its dual function as a toxic metabolite and signaling compound, we speculate that this pedospheric nitric oxide of microbial origin can significantly interact with mycorrhi...
journal_title:Trends in plant science
pub_type: 杂志文章
doi:10.1016/j.tplants.2020.11.007
更新日期:2021-02-01 00:00:00
abstract::Arbuscular mycorrhizal fungi colonize the root systems of most land plants and modulate plant growth by enhancing the availability of nutrients, mainly phosphorus, for plant nutrition. Recently identified genes encoding mycorrhiza-specific plant phosphate transporters have enabled fundamental problems in arbuscular my...
journal_title:Trends in plant science
pub_type: 杂志文章
doi:10.1016/j.tplants.2004.12.003
更新日期:2005-01-01 00:00:00
abstract::While the molecular and cellular basis of self-incompatibility leading to self-pollen rejection in the Brassicaceae has been extensively studied, relatively little attention has been paid to compatible pollen recognition and the corresponding cellular responses in the stigmatic papillae. This is now changing because r...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2016.09.004
更新日期:2016-12-01 00:00:00
abstract::Recent years have witnessed the genomic decoding of a wide range of photosynthetic organisms from the model plant Arabidopsis thaliana and the complex genomes of important crop species to single-celled marine phytoplankton. The comparative sequencing of green, red and brown algae has provided considerable insight into...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2012.02.005
更新日期:2012-07-01 00:00:00
abstract::To exploit plants as living substrates, biotrophic fungi have evolved remarkable variations of their tubular cells, the hyphae. They form infection structures such as appressoria, penetration hyphae and infection hyphae to invade the plant with minimal damage to host cells. To establish compatibility with the host, co...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/s1360-1385(02)02297-5
更新日期:2002-08-01 00:00:00
abstract::Aquaporins are water channel proteins of vacuolar and plasma membranes. When opened they facilitate the passive movement of water molecules down a water potential gradient. In Arabidopsis, 30 genes have been found that code for aquaporin homologues. Some of these genes code for highly abundant constitutively expressed...
journal_title:Trends in plant science
pub_type: 杂志文章
doi:10.1016/s1360-1385(99)01438-7
更新日期:1999-08-01 00:00:00
abstract::Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) fixes atmospheric CO2 into organic compounds and is composed of eight copies each of a large subunit (RbcL) and a small subunit (RbcS). Recent reports have revealed unusual RbcS, which are expressed in particular tissues and confer higher catalytic rate, lesser...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2018.02.006
更新日期:2018-05-01 00:00:00
abstract::Recent discoveries show that jasmonate ZIM-domain (JAZ) transcriptional repressors are key regulators of jasmonate hormonal response. Jasmonate promotes interaction between JAZ proteins and the SCF(COI1) ubiquitin ligase, leading to JAZ degradation via the 26S proteasome in Arabidopsis thaliana. Elimination of JAZ rep...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2007.11.011
更新日期:2008-02-01 00:00:00
abstract::Variation in floral shape is of major interest to evolutionary and pollination biologists, plant systematists and developmental geneticists. Quantifying this variation has been difficult due to the three-dimensional (3D) complexity of angiosperm flowers. By combining 3D geometric representations of flowers obtained by...
journal_title:Trends in plant science
pub_type: 杂志文章
doi:10.1016/j.tplants.2010.05.005
更新日期:2010-08-01 00:00:00
abstract::The creation of transgenic plants has brought significant advances to light in plant biotechnology. However, in spite of the fact that transgenic plants are beginning to be grown widely, controlled transgene integration into a pre-determined site remains to be achieved. Here we suggest two alternative approaches for g...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/s1360-1385(01)01890-8
更新日期:2001-04-01 00:00:00
abstract::Plants emit a diverse array of phytogenic volatile organic compounds (VOCs). The production and emission of VOCs has been an important area of research for decades. However, recent research has revealed the importance of VOC catabolism by plants and VOC degradation in the atmosphere for plant growth and survival. Spec...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/j.tplants.2013.08.011
更新日期:2013-12-01 00:00:00
abstract::When Arabidopsis seedlings are grown on a hard-agar plate, their primary roots show characteristic spiralling movements, apparent as waves, coils and torsions, together with a slanting toward the right-hand side. All these movements are believed to be the result of three different processes acting on the roots: circum...
journal_title:Trends in plant science
pub_type: 杂志文章,评审
doi:10.1016/s1360-1385(01)02152-5
更新日期:2001-12-01 00:00:00