Effect of clonidine on hot flashes in postmenopausal women.

Abstract:

:The effectiveness of clonidine in suppressing the occurrence of postmenopausal hot flashes was examined using a dose-response study design and objective recordings of hot flashes. Patients with frequent flashes were studied before and after oral administration of placebo and 0.1, 0.2, and 0.4 mg of clonidine daily for 2 weeks at each dose level. Finger temperature and skin resistance were recorded as indices of hot flash episodes. Four of 10 subjects beginning the study withdrew because of drug-related side effects. Clonidine was found to reduce significantly the frequency of hot flashes as compared with baseline (P less than .005) and with effects of the placebo (P less than .05). At the maximum dosage the mean rate of hot flash occurrence decreased 46%. It was concluded that clonidine does reduce the frequency of postmenopausal flashes.

journal_name

Obstet Gynecol

authors

Laufer LR,Erlik Y,Meldrum DR,Judd HL

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

583-6

issue

5

eissn

0029-7844

issn

1873-233X

journal_volume

60

pub_type

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