Antipsychotics leading to neuroleptic malignant syndrome in pregnancy.

Abstract:

BACKGROUND:Neuroleptic malignant syndrome (NMS) is characterized by a tetrad of mental status changes, extrapyramidal symptoms, hyperpyrexia, and autonomic instability and can develop after the use of antipsychotics. CASE:A young, multiparous woman presented at 26 weeks of gestation with acute psychosis and was treated with haloperidol until she developed rigidity of her extremities and then was switched to risperidone. She subsequently developed mental status changes, rigidity, hyperthermia, and autonomic instability, leading to a diagnosis of NMS. Risperidone was discontinued and, owing to ongoing psychosis, olanzapine was initiated. Subsequently, her symptoms resolved. CONCLUSION:Neuroleptic malignant syndrome may complicate the treatment of pregnant women using antipsychotics. Clinicians should take into account the risks of untreated psychosis when discontinuing the offending agent and consider initiating alternative pharmacotherapy.

journal_name

Obstet Gynecol

authors

Ghaffari N,Dossett E,Lee RH,Aghajanian P

doi

10.1097/AOG.0b013e31822864af

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

436-438

issue

2 Pt 2

eissn

0029-7844

issn

1873-233X

pii

00006250-201202001-00008

journal_volume

119

pub_type

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