Antipsychotics leading to neuroleptic malignant syndrome in pregnancy.


BACKGROUND:Neuroleptic malignant syndrome (NMS) is characterized by a tetrad of mental status changes, extrapyramidal symptoms, hyperpyrexia, and autonomic instability and can develop after the use of antipsychotics. CASE:A young, multiparous woman presented at 26 weeks of gestation with acute psychosis and was treated with haloperidol until she developed rigidity of her extremities and then was switched to risperidone. She subsequently developed mental status changes, rigidity, hyperthermia, and autonomic instability, leading to a diagnosis of NMS. Risperidone was discontinued and, owing to ongoing psychosis, olanzapine was initiated. Subsequently, her symptoms resolved. CONCLUSION:Neuroleptic malignant syndrome may complicate the treatment of pregnant women using antipsychotics. Clinicians should take into account the risks of untreated psychosis when discontinuing the offending agent and consider initiating alternative pharmacotherapy.


Obstet Gynecol


Ghaffari N,Dossett E,Lee RH,Aghajanian P




Has Abstract


2012-02-01 00:00:00




2 Pt 2










  • Endocervical strip biopsy instrument: an alternative to endocervical curettage.

    abstract::The endocervical strip biopsy instrument obtains strips of endocervical epithelium with attached cervical stroma without excessive bleeding or discomfort to the patient. The intact specimen allows a precise histologic evaluation of endocervical disease processes in patients with abnormal cervical cytology or endometri...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Ostergard DR

    更新日期:1980-11-01 00:00:00

  • A brief screening instrument to detect posttraumatic stress disorder in outpatient gynecology.

    abstract:OBJECTIVE:Posttraumatic stress disorder (PTSD) is a serious anxiety disorder triggered by the experience of trauma. One in 4 individuals exposed to trauma will develop PTSD. Victims of trauma are frequent users of health care, but screening is rarely done and most sequelae remain undetected. Our objectives were 1) to d...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Meltzer-Brody S,Hartmann K,Miller WC,Scott J,Garrett J,Davidson J

    更新日期:2004-10-01 00:00:00

  • ACOG Committee Opinion No. 778 Summary: Newborn Screening and the Role of the Obstetrician-Gynecologist.

    abstract::Newborn screening is the largest genetic screening program in the United States, with approximately 4 million infants screened annually. Newborn screening is a mandatory state-based public health program that provides all newborns in the United States with testing and necessary follow-up health care for a variety of m...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,实务指引



    更新日期:2019-05-01 00:00:00

  • Toxemia in a patient with none of the standard signs and symptoms of preeclampsia.

    abstract::A case of gravida presenting with upper abdominal pain, an elevated serum glutamic oxaloacetic transaminase level, and thrombocytopenia, all of which resolved promptly after delivery, and with none of the standard signs and symptoms needed for the diagnosis of preeclampsia is presented. The issues of how this case rel...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Schwartz ML,Brenner W

    更新日期:1985-09-01 00:00:00

  • Abuse history and chronic pain in women: II. A multivariate analysis of abuse and psychological morbidity.

    abstract:OBJECTIVE:To assess the potential role of childhood and adulthood physical and sexual abuse and complaints of chronic pain in accounting for psychiatric symptomatology in adult women. METHODS:We assessed sexual abuse, physical abuse, depression, anxiety, and somatization in 64 women with chronic pelvic pain, 42 women ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Walling MK,O'Hara MW,Reiter RC,Milburn AK,Lilly G,Vincent SD

    更新日期:1994-08-01 00:00:00

  • Uterine rupture occurring during midtrimester abortion.

    abstract::Uterine rupture is an uncommon complication of midtrimester abortion, occurring more frequently in the older multiparous patient and with the use of high doses of oxytocic agents. The clinical presentation may vary from an unexplained drop in the hematocrit or persistent abdominal pain to profound shock and maternal d...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Graham D

    更新日期:1982-06-01 00:00:00

  • Patterns and progress in ovarian cancer over 14 years.

    abstract:OBJECTIVE:To estimate the change in survival rates of women with ovarian cancer during the past 14 years. METHODS:Women diagnosed with epithelial, germ cell, sarcomas, and sex-cord stromal ovarian tumors were identified from the Surveillance Epidemiology and End Results Database. Demographic and clinicopathologic fact...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Chan JK,Cheung MK,Husain A,Teng NN,West D,Whittemore AS,Berek JS,Osann K

    更新日期:2006-09-01 00:00:00

  • Risk factors for endometrial hyperplasia and cancer among women with abnormal bleeding.

    abstract:OBJECTIVE:To identify independent risk factors for endometrial neoplasia in women with abnormal perimenopausal or postmenopausal bleeding and to use those factors to develop and test a predictive model. METHODS:We conducted a case-control study of women with abnormal perimenopausal or postmenopausal bleeding who had e...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Weber AM,Belinson JL,Piedmonte MR

    更新日期:1999-04-01 00:00:00

  • Gestational weight gain and gestational diabetes mellitus: perinatal outcomes.

    abstract:OBJECTIVE:To examine the association between gestational weight gain and perinatal outcome in women with gestational diabetes mellitus (GDM). METHODS:This is a retrospective cohort study of women with nonanomalous singleton pregnancies with GDM enrolled in the Sweet Success California Diabetes and Pregnancy Program be...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Cheng YW,Chung JH,Kurbisch-Block I,Inturrisi M,Shafer S,Caughey AB

    更新日期:2008-11-01 00:00:00

  • Health Care Provider Adherence to Surgical Guidelines for Risk-Reducing Salpingo-Oophorectomy.

    abstract:OBJECTIVE:To evaluate health care provider adherence to the surgical protocol endorsed by the National Comprehensive Cancer Network and the American College of Obstetricians and Gynecologists at the time of risk-reducing salpingo-oophorectomy and compare adherence between gynecologic oncologists and obstetrician-gyneco...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究


    authors: Wilhite AM,Oestreich MC,Olson M,Bedell SM,Westenberg D,Bangdiwala A,Ikramuddin S,Sanchez-Avila M,Madoff RD,Khalifa MA,Erickson BK

    更新日期:2019-09-01 00:00:00

  • Immunologic thrombocytopenic purpura and pregnancy: six new cases.

    abstract::Six new cases of idiopathic thrombocytopenic purpura (ITP) associated with pregnancy are reported; one of these patients delivered triplets. In addition, 78 patients with 122 pregnancies and 124 fetuses have been reported previously. The maternal mortality rate was 4% and the fetal mortality rate was 18%. Prior recomm...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: O'Reilly RA,Taber BZ

    更新日期:1978-05-01 00:00:00

  • Fostering harmony in labor and delivery: a nursing preceptorship for clinical clerks.

    abstract:OBJECTIVE:The relationship between the specialized nurses of the Labor and Delivery Suite and the medical students who are rotating through the unit as clinical clerks has traditionally been a poor one. The objective of this project was to develop a program which pairs medical students with nurse preceptors to improve ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Skoll MA,Dueckman R,Liston R

    更新日期:2006-07-01 00:00:00

  • Lynch syndrome in women less than 50 years of age with endometrial cancer.

    abstract:OBJECTIVE:To estimate the frequency of mismatch repair deficiencies associated with hereditary nonpolyposis colorectal cancer, or Lynch syndrome, in women less than age 50 with endometrial cancer. METHODS:Consecutive patients less than age 50 diagnosed with endometrial adenocarcinoma were identified. Available patholo...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Matthews KS,Estes JM,Conner MG,Manne U,Whitworth JM,Huh WK,Alvarez RD,Straughn JM Jr,Barnes MN,Rocconi RP

    更新日期:2008-05-01 00:00:00

  • Thyroid Disease in Pregnancy: ACOG Practice Bulletin, Number 223.

    abstract::Both thyrotoxicosis and hypothyroidism are associated with adverse pregnancy outcomes. There also is concern about the effect of overt maternal thyroid disease on fetal development. In addition, medications that affect the maternal thyroid gland can cross the placenta and affect the fetal thyroid gland. This document ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,实务指引



    更新日期:2020-06-01 00:00:00

  • The rise and fall of levonorgestrel implants: 1992-1996.

    abstract:OBJECTIVE:To assess shifts over a 4-year period in attitudes of low-income US women regarding use of levonorgestrel implants. METHODS:An anonymous questionnaire was administered at two different points in time to English-speaking women of reproductive age seeking gynecologic or obstetric care in southeast Texas. The f...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Berenson AB,Wiemann CM,McCombs SL,Somma-Garcia A

    更新日期:1998-11-01 00:00:00

  • The mechanism of reduced antithrombin III activity in women with preeclampsia.

    abstract::The cause(s) of the low plasma antithrombin III activity in women with preeclampsia is unknown. The purpose of this study was to evaluate the relationship between plasma antithrombin III activity and both clotting parameters (platelet count and fibrinopeptide A) and renal parameters (serum creatinine and uric acid con...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Weiner CP

    更新日期:1988-12-01 00:00:00

  • Effects of Two Educational Posters on Contraceptive Knowledge and Intentions: A Randomized Controlled Trial.

    abstract:OBJECTIVE:To compare the Centers for Disease Control and Prevention's (CDC) contraceptive effectiveness poster with a more patient-centered poster on factors affecting the likelihood of using effective contraceptives. METHODS:The posters were tested in a randomized controlled trial. Women were eligible if they were ag...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验


    authors: Anderson S,Frerichs L,Kaysin A,Wheeler SB,Halpern CT,Lich KH

    更新日期:2019-01-01 00:00:00

  • The negative prognostic implications of thrombocytosis in women with stage IB cervical cancer.

    abstract:OBJECTIVE:To determine the association between pretreatment platelet count and survival in women with stage IB cervical cancer. METHODS:Clinical records were reviewed for 219 women with stage IB cervical cancer treated by radical hysterectomy from 1971-1984. Univariate and multivariate analyses were performed to ident...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Rodriguez GC,Clarke-Pearson DL,Soper JT,Berchuck A,Synan I,Dodge RK

    更新日期:1994-03-01 00:00:00

  • Factors affecting survival in stage I and state II carcinoma of the cervix.

    abstract::Eighty-eight cases of Stage I and Stage II carcinoma of the cervix treated with radiotherapy at the University of North Carolina Memorial Hospital between April 1969 and July 1971 are reviewed. The question of whether the radiation time-dose-fraction relationship can be applied to the combination of external beam and ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Welander CE,Montana GS,Saylor WL,Palumbo L,Fowler W

    更新日期:1975-10-01 00:00:00

  • Clear cell adenocarcinoma arising in endometriosis of a previous episiotomy site.

    abstract:BACKGROUND:Malignant transformation of endometriosis in an episiotomy site is rare. CASE:A 42-year-old woman presented with a palpable mass, 2.5 cm in size, just inside the posterior commissure of the vagina, at the site of a previous episiotomy for a vaginal delivery. Three years previously, an endometriotic cyst had...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Kwon YS,Nam JH,Choi G

    更新日期:2008-08-01 00:00:00

  • United States Medical Licensure Examination step 1 scores and obstetrics-gynecology clerkship final examination.

    abstract:OBJECTIVE:To determine if scores from first attempts at the United States Medical Licensure Examination step 1 correlated with obstetrics-gynecology examination scores and identified students at risk of failure. METHODS:All students in obstetrics-gynecology clerkships at the University of Illinois at Chicago from July...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Myles TD

    更新日期:1999-12-01 00:00:00

  • The effect of ephedrine on intrapartum fetal heart rate after epidural analgesia.

    abstract:OBJECTIVE:Adverse fetal heart rate (FHR) changes occur frequently during the first 30 minutes after epidural analgesia. The aim of this study was to estimate whether intravenous administration of ephedrine during induction of epidural analgesia can reduce the frequency of adverse FHR changes. METHODS:We prospectively ...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kreiser D,Katorza E,Seidman DS,Etchin A,Schiff E

    更新日期:2004-12-01 00:00:00

  • Pelvic magnetic resonance imaging in the evaluation of uterine torsion.

    abstract:BACKGROUND:Uterine torsion is defined as the rotation of more than 45 degrees around the long axis of the uterus. An uncommon but potentially fatal event, uterine torsion is rarely diagnosed until the time of surgery. With magnetic resonance imaging (MRI), however, an accurate diagnosis of uterine torsion may now be ma...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Nicholson WK,Coulson CC,McCoy MC,Semelka RC

    更新日期:1995-05-01 00:00:00

  • Diagnosis and Treatment of Vulvar Dermatoses.

    abstract::Vulvar symptoms of pain, dyspareunia, and pruritus are common and may significantly affect a woman's sense of well-being and sexual function. Despite this, vulvar symptoms are often underreported by women. When identified, however, vulvovaginal symptoms should be addressed by health care providers to optimize care. Th...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审


    authors: Stockdale CK,Boardman L

    更新日期:2018-02-01 00:00:00

  • Body mass index and outcome of incontinence surgery.

    abstract:OBJECTIVE:To analyze the influence of body mass on the outcome of surgery for urinary incontinence. METHODS:Among 291 women operated on for stress incontinence, 187 (64%) were available for follow-up at 5 years. Eighty women had anterior colporrhaphy, 49 anterior colporrhaphy with needle suspension of the bladder neck...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Zivkovic F,Tamussino K,Pieber D,Haas J

    更新日期:1999-05-01 00:00:00

  • Committee opinion no 632: Expedited partner therapy in the management of gonorrhea and chlamydial infection.

    abstract::Sexually transmitted infections (STIs) disproportionately affect women and create a preventable threat to their fertility. One factor that contributes to young women's high rates of STIs is reinfection from an untreated sexual partner. One way to address this problem is through expedited partner therapy, the practice ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章



    更新日期:2015-06-01 00:00:00

  • Correlation of nonstressed fetal heart rate with sequential contraction stress test.

    abstract::Two hundred seven high-risk patients were studied prospectively by standardized nonstressed fetal heart rate monitoring followed immediately by contraction stress testing (CST). Of the 604 combined procedures examined, 90.2% of nonstress tests (NST) were interpreted as reactive; none was associated with a positive CST...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Gibbons JM Jr,Nagle P

    更新日期:1980-05-01 00:00:00

  • Active and passive cigarette smoking and the risk of cervical neoplasia.

    abstract:OBJECTIVE:Evidence links active cigarette smoking to cervical neoplasia, but much less is known about the role of passive smoking. Using a prospective cohort design, we examined personal cigarette smoking and household passive smoke exposure in relation to the risk of cervical neoplasia. METHODS:Cohorts were establish...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Trimble CL,Genkinger JM,Burke AE,Hoffman SC,Helzlsouer KJ,Diener-West M,Comstock GW,Alberg AJ

    更新日期:2005-01-01 00:00:00

  • Antenatal treatment of alloimmune thrombocytopenia.

    abstract:OBJECTIVE:Neonatal alloimmune thrombocytopenia is caused by platelet antigen incompatibility between the mother and fetus. Affected fetuses may have severe thrombocytopenia leading to intracranial hemorrhage before or at birth. We sought to treat this condition in utero to prevent these hemorrhages. METHODS:Eighteen w...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Lynch L,Bussel JB,McFarland JG,Chitkara U,Berkowitz RL

    更新日期:1992-07-01 00:00:00

  • Effects of natural menopause, hysterectomy, and oophorectomy on lumbar spine and femoral neck bone densities.

    abstract::Lumbar spine and femoral neck bone densities of women, aged 35-65, were measured by dual photon bone densitometry. After exclusion of women with spinal and other abnormalities, this study included 233 subjects: 60 menstruant, 91 who underwent natural menopause (56 more than 2 years post-menopause), 45 bilaterally ooph...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Hreshchyshyn MM,Hopkins A,Zylstra S,Anbar M

    更新日期:1988-10-01 00:00:00