Effect of antenatal and postnatal corticosteroid therapy on weight gain and head circumference growth in the nursery.

Abstract:

OBJECTIVE:To assess the effect of antenatal and postnatal corticosteroids on head circumference growth and weight gain from birth to discharge. METHODS:We conducted a retrospective analysis of nonanomalous newborns admitted to the neonatal intensive care unit from 23 to 34 6/7 weeks of gestation. Independent variables included maternal age, race, nulliparity, poor prenatal care, multiple gestation, obstetric complications, alcohol, tocolytic drugs, smoking, illicit drugs, gestational age at birth, presentation, method of delivery, 5-minute Apgar score < 7, surfactant use, severe intracranial hemorrhage, and length of stay. RESULTS:Antenatal and postnatal corticosteroids were given in 62% and 14% of the newborns, respectively, and 10% of newborns received both. The mean (+/-SD) weight gain and head circumference growth in the nursery was 440 +/- 582 g (n = 14,217) and 2.54 +/- 3.42 cm (n = 12,808), respectively. After multivariable analysis, use of antenatal corticosteroids did not affect weight gain (3.6 +/- 4.6 g) and head circumference growth (0.05 +/- 0.04 cm) compared with no exposure to perinatal corticosteroids, but postnatal corticosteroids were associated with significant reductions in weight gain and head circumference growth (-120 +/- 12.2 g and -0.53 +/- 0.11 cm, respectively). CONCLUSIONS:Antenatal corticosteroid therapy did not affect weight gain or head circumference growth in the nursery, even when used in conjunction with postnatal corticosteroid therapy.

journal_name

Obstet Gynecol

authors

Thorp JA,Jones PG,Peabody JL,Knox E,Clark RH

doi

10.1016/s0029-7844(01)01657-x

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

109-15

issue

1

eissn

0029-7844

issn

1873-233X

pii

S002978440101657X

journal_volume

99

pub_type

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