Abstract：
OBJECTIVE:To assess whether obesity is an independent predictor of mortality in women with cervical cancer. METHODS:This retrospective cohort study of patients with stages IB1-IVA cervical cancer treated with curative intent at MD Anderson Cancer Center from 1980 through 2007 categorized these women as underweight, normal weight, overweight, obese, or morbidly obese according to National Institutes of Health definitions. In addition to weight category, known prognostic factors for survival after a diagnosis of cervical cancer were included in a multivariate model. These known prognostic factors included age, smoking status, race or ethnicity (self-reported), socioeconomic status, comorbidities, tumor histologic subtype, tumor stage, tumor size, presence or absence of hydronephrosis, radiologic evidence of nodal metastasis, and the addition of concurrent chemotherapy with definitive radiation. RESULTS:A total of 3,086 patients met the inclusion criteria. The median survival for the entire cohort was 81 months (range 0-365 months). The presence of lymph node spread and advancing stage were the most significant predictors of survival. Compared with normal-weight women, morbidly obese women had a significantly higher hazard ratio for both all-cause death (hazard ratio 1.26, 95% confidence interval [CI] 1.10-1.45) and disease-specific death (hazard ratio 1.24, 95% CI 1.06-1.47). Underweight, overweight, and obese women did not have an increased risk for death compared with normal-weight women. CONCLUSION:After controlling for all previously known prognostic factors, morbid obesity remains an independent risk factor for death from cervical cancer. Overweight and obese women have the same prognosis as normal-weight women.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Frumovitz M,Jhingran A,Soliman PT,Klopp AH,Schmeler KM,Eifel PJdoi
10.1097/AOG.0000000000000558subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1098-1104issue
6eissn
0029-7844issn
1873-233Xpii
00006250-201412000-00006journal_volume
124pub_type
杂志文章abstract：:We report three cases of rubeola during pregnancy complicated by pneumonia. All had bacterial superinfection of the lungs and a clinically mild hepatitis. One woman delivered at term and two underwent successful tocolysis, one of whom had an unexplained stillbirth 7 weeks later. Rubeola virus is not a teratogen, altho...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1991-11-01 00:00:00
abstract：:Sickle cell anemia is associated with an alarming attrition rate during pregnancy. The maternal morbidity rate, perinatal wastage rate, and the incidence of severe morbidity in both mother and child are elevated above acceptable limits. In most cases, these statistics have been compiled using conservative therapeutic ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1976-11-01 00:00:00
abstract：:The optimal timing for clamping the umbilical cord after birth has been a subject of controversy and debate. Although many randomized controlled trials in term and preterm infants have evaluated the benefits of delayed umbilical cord clamping versus immediate umbilical cord clamping, the ideal timing for cord clamping...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,实务指引
doi：10.1097/01.AOG.0000423817.47165.48
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Gestational alloimmune liver disease, a form of profound liver failure in the newborn, is the main underlying cause of the entity formerly known as neonatal hemochromatosis. Antepartum maternal intravenous immunoglobulin (IVIG) has been shown to prevent gestational alloimmune liver disease, which otherwise h...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000001569
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:To reorganize reusable laparoscopic instrumentation to promote instrument accessibility, minimize instrument breakage, eliminate infrequently used instruments on permanent trays, and help control maintenance costs. TECHNIQUE:The Robert Wood Johnson University Hospital Gynecologic Steering Committee evaluate...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:In nondiabetic women, pregnancy alone rarely causes clinical hypoglycemia. Non-islet cell tumors have recently been shown to be associated with the production of insulin-like growth factor II (IGF-II) and a paraneoplastic syndrome resulting in hypoglycemia. A case report and review of pathophysiologic mechan...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0029-7844(94)00313-3
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVE:To compare the accuracy of predicted birth weight by the gestation-adjusted projection method using ultrasonographic measurements obtained just before and at term. METHODS:The study group comprised patients with singleton pregnancies who underwent sonograms between 34.0 and 36.9 weeks' gestation (period 1) a...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(99)00617-1
更新日期：2000-04-01 00:00:00
abstract：OBJECTIVE:To identify potential predictors for treatment success in medical management with misoprostol for early pregnancy failure. METHODS:We conducted a planned secondary analysis of data from a multicenter trial that compared medical and surgical management of early pregnancy failure. Medical management consisted ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/01.AOG.0000206737.68709.3e
更新日期：2006-04-01 00:00:00
abstract：:Hypothalamic amenorrhea, a common disorder associated with abnormalities in gonadotropin pulsatility and subsequent estrogen deficiency, is usually transient, and treatment indications are unclear unless fertility is desired. To determine whether this disorder is associated with progressive bone loss, we studied 24 wo...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：BACKGROUND:Takotsubo cardiomyopathy is a cardiac condition associated with the acute onset of chest pain, abnormalities in cardiac enzymes and electrocardiogram, and a distinct pattern of left ventricular dysfunction on echocardiography. This case evaluates an obstetric patient diagnosed with Takotsubo cardiomyopathy d...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e3181662cfe
更新日期：2008-08-01 00:00:00
abstract：:A follow-up study of more than 65,000 healthy women aged 15 to 44 was conducted to assess the association between oral contraceptive use and thromboembolism, stroke, or nonfatal myocardial infarction from 1980 through 1982 at Group Health Cooperative of Puget Sound. A positive association existed between current oral ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:In an ongoing clinical trial, 100 patients with an unruptured ectopic pregnancy of 3.5 cm or less in greatest dimension were treated with an outpatient protocol of methotrexate and citrovorum factor chemotherapy. Methotrexate and citrovorum were given on alternating days until the hCG titer had decreased by 15% on 2 c...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：BACKGROUND:Monoamniotic twin pregnancies are frequently associated with cord entanglement, but such entanglement rarely involves the co-twin's trunk, extremities, or neck. CASE:We report a set of monoamniotic twins in which color Doppler imaging revealed that the cord of twin B was wrapped around the neck of its dead ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:Preterm birth is the leading cause of neonatal mortality and a substantial portion of all birth-related short- and long-term morbidity. Spontaneous preterm labor is responsible for more than half of preterm births. Its management is the topic of this review. Although there are many maternal characteristics associated ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1016/s0029-7844(02)02212-3
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:To evaluate whether preeclampsia is associated with risk of maternal retinal disease in the decades after pregnancy. METHODS:We carried out a longitudinal cohort study of 1,108,541 women who delivered neonates in any hospital in Quebec, Canada, between 1989 and 2013. We tracked women for later hospitalizatio...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000001758
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Aneuploidy is frequently cited as an etiology of hydrops fetalis. Traditionally, associated anomalies (specifically cardiovascular abnormalities) have been postulated as the causative factor. CASES:We report two cases of severe anemia associated with hydrops in fetuses that later proved to have Down syndrom...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:Germ cell tumors, including gonadoblastoma, are usually found in patients with gonadal dysgenesis who have Y chromatin in their genotype. Diffuse calcification is a common finding in gonadoblastomas. Bilateral calcifications in the gonadal sites were seen on the intravenous pyelogram of a patient with 46,XX pure gonad...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1976-10-01 00:00:00
abstract：:The present study is concerned with surveillance/management programs for hereditary ovarian cancer syndromes. These syndromes lack distinguishing premonitory physical signs or biomarkers; therefore, in these genotypic settings, ovarian cancer risk must be assessed by analysis of the patient's pedigree. The authors des...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
abstract：OBJECTIVE:To assess the ectopic pregnancy risk among women who conceived with assisted reproductive technology (ART) procedures. METHODS:The ectopic rate for ART pregnancies was calculated from population-based data of pregnancies conceived with ART in U.S. clinics in 1999-2001. Variation in ectopic risk by patient an...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000196503.78126.62
更新日期：2006-03-01 00:00:00
abstract：:In a randomized four-way crossover study, 32 women with primary dysmenorrhea were treated with transcutaneous electrical nerve stimulation (TENS) for two cycles, placebo (sham) TENS for one cycle, or ibuprofen 400 mg four times a day for one cycle. The TENS setting used was 100 pulses per second with 100-microsecond p...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-04-01 00:00:00
abstract：OBJECTIVE:To investigate the association between maternal use of sulfamethizole near term and the risk of neonatal jaundice. METHODS:We conducted a nationwide population-based retrospective cohort study using Danish registers. All Danish women giving birth between 1995 and 2007 were included from the Danish Fertility ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e318298314f
更新日期：2013-07-01 00:00:00
abstract：INTRODUCTION:The first transdermal drug delivery system was introduced in the United States over 20 years ago. Created as an alternative route of administration to improve patient compliance as well as to reduce side effects, the transdermal delivery of drugs now represents a $1.5 to $2 billion market and is growing ra...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1097/01.AOG.0000161958.70059.db
更新日期：2005-05-01 00:00:00
abstract：:The long-term follow-up is presented of three infants with vulvovaginal rhabdomyosarcoma treated at 10, 11, and 15 months of age by radical surgery, pelvic radiation therapy, and chemotherapy. Two patients developed colonic stricture requiring operative repair. One of these two patients also has urinary incontinence s...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1988-03-01 00:00:00
abstract：:Uteri obtained at the postmortem examination of 164 girls ranging in age from premature and immature infants to 11 years were studied for evidence regarding the developmental changes that take place in the cervix during this period of life and in particular the mechanisms involved in the production and regression of c...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1976-05-01 00:00:00
abstract：OBJECTIVE:To compare the pharmacokinetics of vaginal and oral administration of the prostaglandin E1 analogue, misoprostol. METHODS:Twenty women received 400-micrograms doses of misoprostol either orally or as tablets placed in the vagina. Serum levels of principal metabolite, misoprostol acid, were measured at 7.5, 1...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0029-7844(97)00111-7
更新日期：1997-07-01 00:00:00
abstract：OBJECTIVE:To estimate whether antenatal dietary interventions restrict maternal weight gain in obese pregnant women without compromising newborn birth weight. DATA SOURCES:PubMed and Cochrane Controlled Trials Register were searched using free-text search terms: pregnancy, obesity, overweight, dietary intervention, li...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,meta分析,评审
doi：10.1097/AOG.0b013e3182396bc6
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the obstetric outcomes associated with persistent occiput posterior position of the fetal head in term laboring patients. METHODS:We performed a cohort study of 6434 consecutive, term, vertex, laboring nulliparous and multiparous patients, comparing those who delivered infants in the occiput post...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(03)00068-1
更新日期：2003-05-01 00:00:00
abstract：:The pregnancy of a woman with Friedreich ataxia was complicated by the onset of preterm labor and preeclampsia. Administration of magnesium sulfate (MgSO4.7H2O) in the usual intravenous dosage resulted in the dramatic development of profound motor weakness and respiratory distress. Magnesium acts to antagonize the act...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：OBJECTIVE:To review our experience with antenatal detection and subsequent neonatal outcome of fetuses with a persistent right umbilical vein. METHODS:In a prospective observational study, 33 cases of persistent right umbilical vein were detected during 15,237 obstetric ultrasound examinations performed after 15 weeks...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:A preterm birth prevention program consisting of risk scoring, intensive weekly observation including cervical examinations, and detailed education about preterm labor signs and symptoms was tested in a predominantly black, indigent population. One thousand high-risk women were randomized to treatment or control group...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-06-01 00:00:00
