Abstract:
INTRODUCTION:The first transdermal drug delivery system was introduced in the United States over 20 years ago. Created as an alternative route of administration to improve patient compliance as well as to reduce side effects, the transdermal delivery of drugs now represents a $1.5 to $2 billion market and is growing rapidly. DATA SOURCES:The medical literature from 1980 to 2005 was searched using the PubMed search engine. The search term was "transdermal," limited to human clinical trials. Abstracts were used to identify clinical trials that compared transdermal preparations and their oral counterparts in the same study. TABULATION, INTEGRATION, AND RESULTS:In this article, we review the rationale for the transdermal administration of drugs; discuss aspects of the anatomy and physiology of the skin relevant to drug transport; examine the qualities required for a drug to be a good candidate for transdermal delivery; and consider key principles for the evaluation of the relative benefits of transdermal delivery, using studies of hormone replacement therapy and oral contraceptive as examples. CONCLUSION:The data reviewed here suggest that certain clinical situations support the use of the transdermal administration of drugs over their oral counterparts.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Potts RO,Lobo RAdoi
10.1097/01.AOG.0000161958.70059.dbsubject
Has Abstractpub_date
2005-05-01 00:00:00pages
953-61issue
5 Pt 1eissn
0029-7844issn
1873-233Xpii
105/5/953journal_volume
105pub_type
杂志文章,评审abstract::Rates of perforation for different types of IUDs vary from 1 per 150 insertions with the bow to 1 per 2500 with the loop. Incidence of perforation varies with insertion technic. Not all perforations occur at the time of insertion but most do. These perforations may be partial or complete, with or without symptoms, ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1972-08-01 00:00:00
abstract::Cytologic diagnosis of adenocarcinoma metastatic to the peritoneal surface is often hampered by the difficulty of differentiating between reactive mesothelial cells and macrophages from malignant epithelial cells by light microscopy. With in vitro tissue culture technics, the fibroblastic dedifferentiation of mesothel...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/00006250-197507000-00015
更新日期:1975-07-01 00:00:00
abstract::A new sensitive and rapid enzyme-linked immunosorbent assay (ELISA) test (Du Pont HERPCHEK) for the detection of herpes simplex virus (HSV) antigen was evaluated. A total of 563 clinical samples collected from patients attending obstetrics and gynecology and sexually transmitted disease clinics in two geographic locat...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::One hundred patients undergoing pelvic exenteration (total 69, anterior 13, posterior 18) at the University of Michigan Medical Center from 1964-1984 are reported. All patients were followed for at least 5 years or until time of death. The overall cumulative survival was 66% at 3 years and 61% at 5 years. The age of t...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:Uterine leiomyosarcoma is an aggressive tumor that has a propensity for distant metastasis. Distant sites of spread include the lung, liver, brain, and bone. CASE:A woman in her 5th decade was diagnosed with stage IV leiomyosarcoma of the uterus. Distant metastasis in the chest was confirmed by thoracotomy ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(02)02191-9
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Nocardiosis is an uncommon disease, and the primary skin infection is usually at the site of a recent injury. Nocardia is a saprophytic bacterium of the soil belonging to the order Actinomycetales. CASE:A 68-year-old woman presented with a painful, hard, dark reddish lesion located in the right hemivulva. S...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/01.AOG.0000188068.10174.90
更新日期:2006-09-01 00:00:00
abstract::The management of polycystic ovarian disease in women not desiring pregnancy is controversial. To avoid the progressive androgenic effects on peripheral target organs, some advocate the use of oral contraceptives. This study reports the effects of a preparation with 50 micrograms ethinyl estradiol and 2 mg cyproterone...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1987-02-01 00:00:00
abstract::Despite earlier studies, there remain unanswered questions regarding urinary calculi in pregnancy. The authors studied 11 cases in 11,292 deliveries over 5 years. Eight previous studies were also studied and data were compiled from 96 cases in 138,296 patients. The incidence of urinary calculi in pregnancy is approxim...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1980-10-01 00:00:00
abstract::Uterine activity monitoring to detect preterm contractions and thus to manage patients in active labor is valuable to the clinician. Uterine activity measured by external devices using the guard ring principle or by standard tocodynamometers has been shown to be accurate concerning the frequency of uterine activity as...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:To identify metabolic and obstetric risk factors associated with hypertension after preeclampsia. METHODS:We analyzed demographic and clinical data from a postpartum screening (blood pressure, microalbuminuria and fasting plasma levels of glucose, insulin, and lipid profile) from 683 primiparous women with a...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e31825f21ff
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Infection and endotoxemia have been associated with neurologic injury in the newborn. In addition, recent reports have noted an increased incidence of fetal neurologic injury in the presence of intrauterine infection. CASES:Three pregnancies complicated by acute appendicitis and refractory preterm labor res...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/0029-7844(95)00211-9
更新日期:1995-10-01 00:00:00
abstract:OBJECTIVE:To estimate fatal and nonfatal opioid overdose events in pregnant and postpartum women in Massachusetts, comparing rates in individuals receiving and not receiving pharmacotherapy for opioid use disorder (OUD). METHODS:We conducted a population-based retrospective cohort study using linked administrative and...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000002734
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the Interstitial Cystitis Symptom Index and Problem Index as a screening tool for interstitial cystitis, and to estimate the prevalence and risk factors for interstitial cystitis in women with chronic pelvic pain. METHODS:Forty-five women scheduled to undergo laparoscopy for chronic pelvic pain w...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(02)02087-2
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the feasibility of examining the fetal ear with three-dimensional ultrasound. METHODS:In 125 pregnancies between 19 and 38 weeks of gestation, fetal ears were evaluated by three-dimensional ultrasound. The volume images with surface rendering were analyzed to depict the morphology, lying axis, or...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(98)00021-0
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Currently, maternal-fetal surgery for repair of myelomeningocele requires an upper-segment hysterotomy, which likely increases maternal postsurgical risks. If fetoscopic repair of myelomeningocele achieves similar or better fetal outcomes while decreasing maternal risks, it would be a better option. CASE:A ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000000835
更新日期:2015-10-01 00:00:00
abstract::In a study of 50 women of child-bearing age, half of whom had infertility problems, it was demonstrated that the infertile group more commonly yielded Ureaplasma urealyticum on culture (84% versus 60%), had more than twice the recoveries from the endocervical canal than fertile women had (80% verse 36%), and grew a mu...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1979-11-01 00:00:00
abstract::Three patients with International Federation of Gynecology and Obstetrics state IIIC ovarian adenocarcinoma underwent CO2 laser vaporization of large-volume (5-6 cm) and miliary right hemidiaphragmatic metastases at the conclusion of standard debulking surgery to effect optimal cytoreduction. Destruction of diaphragma...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::Dysmenorrhea, or menstrual pain, is the most common menstrual symptom among adolescent girls and young women. Most adolescents experiencing dysmenorrhea have primary dysmenorrhea, defined as painful menstruation in the absence of pelvic pathology. When the patient's history suggests primary dysmenorrhea, empiric treat...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000002981
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:To evaluate a possible correlation between a new variable-persistent breech presentation-and the success rate of external cephalic version (ECV). METHODS:This was a retrospective study of ECVs performed from January 2008 through January 2019 in an Israeli tertiary care hospital. The study group included all ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000004231
更新日期:2021-02-01 00:00:00
abstract::Methods to prevent perineal trauma during childbirth include avoiding episiotomy and forceps delivery and slowing delivery of the head to allow the perineum time to stretch. Each intervention can lengthen the second stage of labor and change the biophysical stresses on infants and the pelvic floor. Available evidence ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(99)00609-2
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To measure the accessibility of contraceptive supplies over the Internet. METHODS:We performed an Internet search with the use of search engines and key words. We posed as consumers purchasing both prescription and over-the-counter contraceptive supplies. The number of clicks or web pages accessed, costs, sh...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(00)01113-3
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the frequency, distribution, and most likely etiology of hematologic and weight discordance in pathologically proven monochorionic twins, and to use this information to reevaluate the neonatally derived definition of the twin-twin transfusion syndrome. METHODS:We re...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::A method of reanastomosis of the uterine tube after Pomeroy tubal ligation is presented. The pregnancy rate was 69%. The viable birth rate was 38%, with 1 ectopic pregnancy, 2 patients pregnant, and 1 patient lost to followup at the time of this report. ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:It has been suggested that Q fever infection in pregnancy is associated with various maternal and neonatal adverse outcomes, including intrauterine growth restriction, stillbirth, preterm delivery, intrauterine fetal death, and oligohydramnios. CASE:We describe the cases of two pregnant women remote from te...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e318260590f
更新日期:2012-08-01 00:00:00
abstract::A method of removing an IUD whose strings may be lost is discussed. Having identified the intrauterine location of the IUD by touch with probe, a second Lippes loop was placed and the long strings not trimmed at all. When the patient returned later the most recently placed loop was removed and the strings of the fir...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1974-07-01 00:00:00
abstract::The greater vestibular glands produce a secretion during the plateau stage of sexual response. If the duct of the gland is partially or completely occluded, the secretion cannot be released and pain results from the pressure of the entrapped secretion. The pain is specific in its location and is elicited regardless of...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract::Vaginal hysterectomy fulfills the evidence-based requirements as the preferred route of hysterectomy for benign gynecologic disease. Despite proven safety and effectiveness, the vaginal approach for hysterectomy has been and remains underused in surgical practice. Factors associated with underuse of vaginal hysterecto...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000000398
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Laparoscopic cholecystectomy is becoming a popular surgical option in the management of gallstone disease. Reports on complications of this procedure have usually focused on prolonged operative time, bleeding, and infections. We describe a case of cholelithiasis of the ovary following laparoscopic cholecyste...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to describe identifiers and estimate maternal and neonatal outcomes in women who attempt suicide during pregnancy. METHODS:A linked Vital Statistics-Patient Discharge database of the State of California was used to identify cases of intentional injury during pregnancy. A retrosp...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/01.AOG.0000216000.50202.f6
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of shared decision making using a simple decision aid for opioid prescribing after hysterectomy. METHODS:We conducted a prospective quality initiative study including all patients undergoing hysterectomy for benign, nonobstetric indications between March 1, 2018, and July 31, 2018, at...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000003468
更新日期:2019-10-01 00:00:00