Factors related to successful misoprostol treatment for early pregnancy failure.

Abstract:

OBJECTIVE:To identify potential predictors for treatment success in medical management with misoprostol for early pregnancy failure. METHODS:We conducted a planned secondary analysis of data from a multicenter trial that compared medical and surgical management of early pregnancy failure. Medical management consisted of misoprostol 800 mug vaginally on study day 1, with a repeat dose if indicated on day 3. Women returned on days 3 and 15, and a telephone interview was conducted on day 30. Failure was defined as suction aspiration for any reason within 30 days. Demographic, historical, and outcome variables were included in univariable analyses of success. Multivariable analyses were conducted using clinical site, gestational age, and variables for which the univariable analysis resulted in a P < .1 to determine predictors of overall treatment success and first-dose success. RESULTS:Of the 491 women who received misoprostol, 485 met the criteria for this secondary analysis. Lower abdominal pain or vaginal bleeding within the last 24 hours, Rh-negative blood type, and nulliparity were predictive of overall success. However, only vaginal bleeding within the last 24 hours and parity of 0 or 1 were predictive of first-dose success. Overall success exceeds 92% in women who have localized abdominal pain within the last 24 hours, Rh-negative blood type, or the combination of vaginal bleeding in the past 24 hours and nulliparity. CONCLUSION:Misoprostol treatment for early pregnancy failure is highly successful in select women, primarily those with active bleeding and nulliparity. Clinicians and patients should be aware of these differences when considering misoprostol treatment. LEVEL OF EVIDENCE:II-2.

journal_name

Obstet Gynecol

authors

Creinin MD,Huang X,Westhoff C,Barnhart K,Gilles JM,Zhang J,National Institute of Child Health and Human Development Management of Early Pregnancy Failure Trial.

doi

10.1097/01.AOG.0000206737.68709.3e

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

901-7

issue

4

eissn

0029-7844

issn

1873-233X

pii

107/4/901

journal_volume

107

pub_type

杂志文章,多中心研究,随机对照试验
  • Risk factors for lower urinary tract symptoms in women 40 to 60 years of age.

    abstract:OBJECTIVE:To determine the relationship between lower urinary tract symptoms and possible associated risk factors in women 40-60 years old. METHODS:In a normal population study, 502 women with lower urinary tract symptoms and 742 women with no symptoms (controls) were asked about possible associated factors. RESULTS:...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Alling Møller L,Lose G,Jørgensen T

    更新日期:2000-09-01 00:00:00

  • Umbilical cord blood interleukin-6 levels and neonatal morbidity.

    abstract:OBJECTIVE:To study umbilical cord interleukin-6 levels and the occurrence of neonatal sepsis, congenital pneumonia, necrotizing enterocolitis, and grade II-IV intraventricular hemorrhage. METHODS:Umbilical cord blood was collected from 133 preterm newborns. The study population was divided according to the presence or...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/S0029-7844(97)00421-3

    authors: Weeks JW,Reynolds L,Taylor D,Lewis J,Wan T,Gall SA

    更新日期:1997-11-01 00:00:00

  • A rapid method for the presurgical cleansing of hands.

    abstract::A new rapid method of presurgical cleansing of the hands has been evaluated in a clinical setting. The effectiveness of a 90 second jet wash has been compared with a standard 10-minute presurgical scrub. Bacteriologic cultures were obtained from the fingertips of interns, residents, and staff of the Department of Obst...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Decker LA,Gross A,Miller FC,Read JA,Cutright DE,Devine J

    更新日期:1978-01-01 00:00:00

  • Treatment of common gynecologic-endocrinologic symptoms by allergy management procedures.

    abstract::The technique of managing allergies by optimum-dose (provocative neutralization) testing and treatment using aqueous progesterone has been studied in 132 women having progesterone-related symptoms due to the menstrual cycle, pregnancy, or exogenous hormone administration. When extremely small doses of progesterone (0....

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Mabray CR,Burditt ML,Martin TL,Jaynes CR,Hayes JR

    更新日期:1982-05-01 00:00:00

  • Diagnostic accuracy of fetal heart rate monitoring in the identification of neonatal encephalopathy.

    abstract:OBJECTIVE:To estimate the diagnostic accuracy of electronic fetal heart rate abnormalities in the identification of neonates with encephalopathy treated with whole-body hypothermia. METHODS:Between January 1, 2007, and July 1, 2013, there were 39 neonates born at two hospitals within our system treated with whole-body...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000000424

    authors: Graham EM,Adami RR,McKenney SL,Jennings JM,Burd I,Witter FR

    更新日期:2014-09-01 00:00:00

  • Role of dehydroepiandrosterone sulfate as a prehormone for ovarian steroidogenesis.

    abstract::The endocrine effects of induction of ovulation with menotropins were studied in 43 patients: 11 with hypothalamic amenorrhea and 32 with the polycystic ovary syndrome. Patients with polycystic ovary syndrome had higher base-line values of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17 beta-est...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Haning RV Jr,Austin CW,Carlson IH,Kuzma DL,Zweibel WJ

    更新日期:1985-02-01 00:00:00

  • Treatment of vaginal condylomata acuminata by weekly topical application of 5-fluorouracil.

    abstract::Twenty nonpregnant women with condylomata acuminata of the vagina were studied to assess the effectiveness of weekly topical 5-fluorouracil application. All patients were instructed to insert an applicator one-third full of 5% 5-fluorouracil cream (approximately 1.5 g) deeply into the vagina at bedtime once each week ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Krebs HB

    更新日期:1987-07-01 00:00:00

  • Fetal renal malformation following treatment of Hodgkin's disease during pregnancy.

    abstract::A case of human fetal renal maldevelopment following the administration of nitrogen mustard, vincristine, procarbazine, and prednisone in early pregnancy for therapy of Hodgkin's disease is reported. While these agents have been shown to be teratogenic in animal experiments, adverse fetal effects following their use d...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Mennuti MT,Shepard TH,Mellman WJ

    更新日期:1975-08-01 00:00:00

  • Pain perception in women with dysmenorrhea.

    abstract:OBJECTIVE:To determine if systemic processing of pain differs in women with and without dysmenorrhea. METHODS:Twenty-two dysmenorrheic women and 31 nondysmenorrheic women were studied by pain threshold and supra-threshold magnitude estimation to heat stimuli, pain-evoked potentials by laser stimuli, and anxiety scores...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(01)01465-x

    authors: Granot M,Yarnitsky D,Itskovitz-Eldor J,Granovsky Y,Peer E,Zimmer EZ

    更新日期:2001-09-01 00:00:00

  • Gonadal calcification. Indication for gonadectomy in gonadal dysgenesis.

    abstract::Germ cell tumors, including gonadoblastoma, are usually found in patients with gonadal dysgenesis who have Y chromatin in their genotype. Diffuse calcification is a common finding in gonadoblastomas. Bilateral calcifications in the gonadal sites were seen on the intravenous pyelogram of a patient with 46,XX pure gonad...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Schiller PJ,Tagatz GE

    更新日期:1976-10-01 00:00:00

  • Effect of clonidine on hot flashes in postmenopausal women.

    abstract::The effectiveness of clonidine in suppressing the occurrence of postmenopausal hot flashes was examined using a dose-response study design and objective recordings of hot flashes. Patients with frequent flashes were studied before and after oral administration of placebo and 0.1, 0.2, and 0.4 mg of clonidine daily for...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Laufer LR,Erlik Y,Meldrum DR,Judd HL

    更新日期:1982-11-01 00:00:00

  • Immunologic detection of condylomata acuminata-specific antigens.

    abstract::A rabbit serum fraction was prepared which contained antibody specific for unique antigen(s) found in human condylomata acuminata tissue but not in other human papillomatous or normal tissues. Indirect immunofluorescent staining of cryostat sections of human tissues demonstrated an intense nuclear fluorescence in cell...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Dunn J,Weinstein L,Droegemueller W,Meinke W

    更新日期:1981-03-01 00:00:00

  • Cervical sonography in preterm labor.

    abstract:OBJECTIVE:To improve the accuracy of the diagnosis of preterm labor by comparing transvaginal sonography to digital examination of the cervix. METHODS:We performed transvaginal sonography in women with preterm labor who had completed a course of parenteral tocolysis. Cervical length was measured according to criteria ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Iams JD,Paraskos J,Landon MB,Teteris JN,Johnson FF

    更新日期:1994-07-01 00:00:00

  • Cooperative approach to the treatment of cervical cancer.

    abstract::This study covers 20 years' experience in the treatment of carcinoma of the cervix. Improved results and a decreased rate of major complications are seen as a result of a cooperative approach in treatment planning and careful dosimetry. Comparisons are made with large treatment centers as well as with national surviva...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Given FT Jr,Frazier AB,Hancock JA Jr,Pfeiffer GW

    更新日期:1978-10-01 00:00:00

  • Tips of the slongue: the enduring legacy of W.A. Spooner.

    abstract::Slips of the tongue are common and often amusing phonic errors. Although surely not the first speaker to make such transpositions, W.A. Spooner (1844-1930) was well known for them and was the source of the eponym, "Spoonerism." Several of his noted slips are presented along with a whimsical obstetric presentation. ...

    journal_title:Obstetrics and gynecology

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/s0029-7844(97)00146-4

    authors: Gibbs RS

    更新日期:1997-06-01 00:00:00

  • A critical evaluation of transvaginal Doppler studies, transvaginal sonography, magnetic resonance imaging, and CA 125 in detecting ovarian cancer.

    abstract:OBJECTIVE:To evaluate whether transvaginal Doppler ultrasound is more valid than transvaginal sonography, magnetic resonance imaging (MRI), and CA 125 in differentiating malignant from benign ovarian tumors. METHODS:Sixty-three patients with ovarian tumors (36 benign and 27 malignant) were studied with transvaginal Do...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Hata K,Hata T,Manabe A,Sugimura K,Kitao M

    更新日期:1992-12-01 00:00:00

  • Association of Pharmacist Prescription of Hormonal Contraception With Unintended Pregnancies and Medicaid Costs.

    abstract:OBJECTIVE:To estimate unintended pregnancies averted and the cost effectiveness of pharmacist prescription of hormonal contraception. METHODS:A decision-analytic model was developed to determine the cost effectiveness of expanding the scope of pharmacists to prescribe hormonal contraception compared with the standard ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000003265

    authors: Rodriguez MI,Hersh A,Anderson LB,Hartung DM,Edelman AB

    更新日期:2019-06-01 00:00:00

  • Surgical management of irradiation-induced small bowel damage.

    abstract::Seventy-seven patients, presenting with radiation small bowel injuries at the University of Texas M. D. Anderson Hospital and Tumor Institute at Houston between 1962 and 1978, were analyzed retrospectively. The patients were divided into two categories: bowel bypass without resection, and resection of irradiated bowel...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Smith ST,Seski JC,Copeland LJ,Gershenson DM,Edwards CL,Herson J

    更新日期:1985-04-01 00:00:00

  • Social support in improving perinatal outcome: the Resource Mothers Program.

    abstract::This report studies the Resource Mothers Program, an organization that improves perinatal outcome through social support. Resource Mothers are nonprofessional women who combine warmth, parenting experience, and knowledge of their local community services to reduce the hazards associated with rural adolescent pregnancy...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Heins HC Jr,Nance NW,Ferguson JE

    更新日期:1987-08-01 00:00:00

  • Enchancement of deficient pituitary response to luteinizing hormone releasing hormone in patients with primary amenorrhea.

    abstract::Although the absence of pituitary response to the luteinizing hormone releasing hormone (LHRH) test has been considered proof of a lesion primarily localized at the pituitary level, the possibility exists that an absent pituitary response may represent only the effect of a chronic deficiency of hypothalamic secretion....

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Serra GB,Muscatello P,Menini E,Lafuenti G,Caniglia R

    更新日期:1975-05-01 00:00:00

  • Preterm premature rupture of membranes. Nutritional and socioeconomic factors.

    abstract:OBJECTIVE:To estimate if there were dietary or socioeconomic factors associated with preterm premature rupture of membranes (PROM). METHODS:In this case-control study, women with preterm PROM (n = 46) were compared with healthy pregnant women matched for gestational age and vitamin supplementation. Measurements includ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(02)02380-3

    authors: Ferguson SE,Smith GN,Salenieks ME,Windrim R,Walker MC

    更新日期:2002-12-01 00:00:00

  • Sonographic evaluation of the bladder neck in continent and stress-incontinent women.

    abstract:OBJECTIVE:To evaluate a new sonographic method to measure depth and width of proximal urethral dilation during coughing and Valsalva maneuver and to report its use in a group of stress-incontinent and continent women. METHODS:Fifty-eight women were evaluated, 30 with and 28 without stress incontinence proven urodynami...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(98)00420-7

    authors: Schaer GN,Perucchini D,Munz E,Peschers U,Koechli OR,Delancey JO

    更新日期:1999-03-01 00:00:00

  • Transvaginal endometrial sonography in postmenopausal women taking tamoxifen.

    abstract:OBJECTIVE:To evaluate sonographic measurements of endometrial thickness in postmenopausal women taking adjuvant tamoxifen therapy for breast cancer, and to correlate sonographic and pathologic findings to symptoms and duration of tamoxifen therapy. METHODS:Medical records and sonograms of 80 postmenopausal women treat...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(98)00418-9

    authors: Tesoro MR,Borgida AF,MacLaurin NA,Asuncion CM

    更新日期:1999-03-01 00:00:00

  • Diagnosis and management of epithelial ovarian cancer.

    abstract::Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the United States. Although there has been a statistically significant improvement in 5-year survival, in 2005 more than 16,000 women were expected to die of this disease. To date, there is no reliable method to screen for ovarian cance...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.AOG.0000220516.34053.48

    authors: Bhoola S,Hoskins WJ

    更新日期:2006-06-01 00:00:00

  • What Is New in Validation and Simulation Training?: Best Articles From the Past Year.

    abstract::This month we focus on current research in validation and simulation training. Dr. Buek discusses four recent publications, which are concluded with a "bottom line" that is the take-home message. A complete reference for each can be found on on this page along with direct links to the abstracts. ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000003592

    authors: Buek J

    更新日期:2019-12-01 00:00:00

  • Laparoscopic sterilization. Review of 3600 cases.

    abstract::A review of 3600 cases of laparoscopy sterilization at the John Hopkins Hospital, between the years 1968-1972, is presented. Technics, complications and failure rate are discussed. The criteria for sterilization were: 1) that the patient be 21 years old (unless mentally retarded or unless the patient was a teenager ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Wheeless CR Jr,Thompson BH

    更新日期:1973-11-01 00:00:00

  • Revisiting the fetal loss rate after second-trimester genetic amniocentesis: a single center's 16-year experience.

    abstract:OBJECTIVE:To estimate an institution's specific fetal loss rate after a second-trimester genetic amniocentesis. METHODS:This is a retrospective cohort study using our prenatal diagnosis database for all pregnant women presenting for care between 1990 and 2006. We compared the fetal loss rate in women who underwent amn...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e318162eb53

    authors: Odibo AO,Gray DL,Dicke JM,Stamilio DM,Macones GA,Crane JP

    更新日期:2008-03-01 00:00:00

  • Immunologic thrombocytopenic purpura and pregnancy: six new cases.

    abstract::Six new cases of idiopathic thrombocytopenic purpura (ITP) associated with pregnancy are reported; one of these patients delivered triplets. In addition, 78 patients with 122 pregnancies and 124 fetuses have been reported previously. The maternal mortality rate was 4% and the fetal mortality rate was 18%. Prior recomm...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00006250-197805000-00018

    authors: O'Reilly RA,Taber BZ

    更新日期:1978-05-01 00:00:00

  • Hand-held computer operating system program for collection of resident experience data.

    abstract:OBJECTIVE:To describe a system for recording resident experience involving hand-held computers with the Palm Operating System (3 Com, Inc., Santa Clara, CA). PROGRAM DESCRIPTION:Hand-held personal computers (PCs) are popular, easy to use, inexpensive, portable, and can share data among other operating systems. Residen...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(00)01015-2

    authors: Malan TK,Haffner WH,Armstrong AY,Satin AJ

    更新日期:2000-11-01 00:00:00

  • Thermoregulation during aerobic exercise in pregnancy.

    abstract::To characterize maternal thermal balance during pregnancy, the authors recorded the thermal response to moderate weight bearing exercise stress in four aerobically conditioned pregnant women. Studies were performed in a climate-controlled environment in each trimester of pregnancy and postpartum after modifying the ex...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Jones RL,Botti JJ,Anderson WM,Bennett NL

    更新日期:1985-03-01 00:00:00