Umbilical cord blood interleukin-6 levels and neonatal morbidity.

Abstract:

OBJECTIVE:To study umbilical cord interleukin-6 levels and the occurrence of neonatal sepsis, congenital pneumonia, necrotizing enterocolitis, and grade II-IV intraventricular hemorrhage. METHODS:Umbilical cord blood was collected from 133 preterm newborns. The study population was divided according to the presence or absence of neonatal complications. Interleukin-6 levels and clinical characteristics were compared by univariate and multivariate analyses. RESULTS:Sixteen neonates had adverse outcomes, and 117 were unaffected. The median interleukin-6 level was significantly higher in affected than in unaffected infants (145 pg/mL versus 0 pg/mL, P = .002). Elevated interleukin-6 levels were associated independently with neonatal morbidity in multiple logistic regression modeling that included gestational age, birth weight, and antenatal steroid exposure. CONCLUSION:Umbilical cord blood interleukin-6 levels are elevated in neonates who subsequently develop sepsis, congenital pneumonia, necrotizing enterocolitis, or grade II-IV intraventricular hemorrhage.

journal_name

Obstet Gynecol

authors

Weeks JW,Reynolds L,Taylor D,Lewis J,Wan T,Gall SA

doi

10.1016/S0029-7844(97)00421-3

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

815-8

issue

5

eissn

0029-7844

issn

1873-233X

pii

S0029-7844(97)00421-3

journal_volume

90

pub_type

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