X-chromosome hyperploidy in couples with multiple spontaneous abortions.

Abstract:

:From 1973 to 1983, cytogenetic analyses were performed on blood samples from 144 couples referred because of two or more spontaneous abortions. Any couple with abnormal offspring in addition to the miscarriages was excluded from the study. Two balanced translocations were found in the 288 individuals examined (0.7%). There was a high frequency of phenotypically normal individuals with cells hyperploid for the X chromosome. This may be a manifestation of an impaired genetic control of chromosome disjunction in these patients.

journal_name

Obstet Gynecol

authors

Holzgreve W,Schonberg SA,Douglas RG,Golbus MS

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

237-40

issue

2

eissn

0029-7844

issn

1873-233X

journal_volume

63

pub_type

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