Abnormalities of lymphocyte transformations in women with intraepithelial carcinoma of the vulva.


:Cellular immunity of the delayed type in women with intraepithelial carcinoma (carcinoma is situ) of the vulva was investigated by an in vitro assay of mitogen-induced lymphocyte transformations. Test results from 9 patients were compared to those of 23 age-matched control subjects. Lymphocyte transformation responses in counts per minute were significantly lower for women with carcinoma in situ of the vulva than for control subjects for phytohemagglutinin-P (at 50 microgram/ml) 6238 and 28,102 (P less than 0.0001); for phytohemagglutinin-P (at 165 microgram/ml 7222 and 21,417 (P less than 0.001); for concanavallin A, 14,988 and 41,888 (P less than 0.0001); and pokeweed mitogen, 20,861 and 49,601 (P less than 0.001). No significant differences in lymphocyte transformations were noted between these two groups to the specific antigens, Candida or streptokinase-streptodornase. Four patients with carcinoma in situ of the vulva were also found to have intraepithelial carcinoma of the cervix and/or vegina. The occurrence and clinical course of carcinoma in situ of the vulva in some women may be related to an underlying defect in cellular immunity. Immunosuppression may also explain the frequent association noted between carcinoma of the vulva and the development of other malignant neoplasms.


Obstet Gynecol


Seski JC,Reinhalter ER,Silva J Jr


Has Abstract


1978-09-01 00:00:00












  • Elective cesarean delivery, neonatal intensive care unit admission, and neonatal respiratory distress.

    abstract:OBJECTIVE:To evaluate the relationship among gestational age at elective cesarean delivery, neonatal intensive care unit (NICU) admission, and whether the presence of pre-cesarean delivery labor or ruptured membranes affected the incidence of neonatal respiratory distress. METHODS:A chart review was performed of all e...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Yee W,Amin H,Wood S

    更新日期:2008-04-01 00:00:00

  • Fetal bradycardia associated with maternal hypothermia.

    abstract::A case of fetal bradycardia associated with severe maternal hypothermia (92.9F) is reported. Until maternal temperature was corrected, the baseline fetal heart rate (FHR) remained between 90-110 beats per minute without other evidence of fetal distress and despite normal maternal blood pressure and pulse. With rewarmi...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Jadhon ME,Main EK

    更新日期:1988-09-01 00:00:00

  • A brief screening instrument to detect posttraumatic stress disorder in outpatient gynecology.

    abstract:OBJECTIVE:Posttraumatic stress disorder (PTSD) is a serious anxiety disorder triggered by the experience of trauma. One in 4 individuals exposed to trauma will develop PTSD. Victims of trauma are frequent users of health care, but screening is rarely done and most sequelae remain undetected. Our objectives were 1) to d...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Meltzer-Brody S,Hartmann K,Miller WC,Scott J,Garrett J,Davidson J

    更新日期:2004-10-01 00:00:00

  • Amenorrhea related to progestin excess in congenital adrenal hyperplasia.

    abstract::Studies of the cause of amenorrhea in a patient with congenital adrenal hyperplasia (CAH) whose androgen levels were easily controlled suggested that inhibition of menses in CAH is more closely related to overproduction of progestins than to overproduction of androgens. Supporting this concept was the observation in a...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Rosenfield RL,Bickel S,Razdan AK

    更新日期:1980-08-01 00:00:00

  • Medical licensure examination scores: relationship to obstetrics and gynecology examination scores.

    abstract:OBJECTIVE:We studied the correlations between both Step 1 and Step 2 of the United States Medical Licensure Examination (USMLE) and the National Board of Medical Examiners Obstetrics and Gynecology Examination (NBME-OB/GYN). METHODS:From July 1994 until June 2001, all third-year medical students at Texas Tech Universi...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Myles TD,Henderson RC

    更新日期:2002-11-01 00:00:00

  • Antenatal Corticosteroid Therapy Before 24 Weeks of Gestation: A Systematic Review and Meta-analysis.

    abstract:OBJECTIVE:To evaluate the effectiveness of antenatal corticosteroids compared with placebo or no treatment in neonates born before 24 weeks of gestation. DATA SOURCES:We searched MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Cochrane Central Register of Controlled Trials datab...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,meta分析,评审


    authors: Park CK,Isayama T,McDonald SD

    更新日期:2016-04-01 00:00:00

  • Academic manpower for obstetrics and gynecology in the United States.

    abstract::All 119 medical schools in the United States provided information for a study of academic manpower conducted by the Association of Professors of Gynecology and Obstetrics (APGO). The average number of full-time faculty members per medical school is 13.2, with 2 positions vacant per school. Subspecialists are concentra...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Messer RH,Pearse WH,Fielden JG

    更新日期:1979-05-01 00:00:00

  • "Living cytology" in the diagnosis of intraabdominal adenocarcinoma.

    abstract::Cytologic diagnosis of adenocarcinoma metastatic to the peritoneal surface is often hampered by the difficulty of differentiating between reactive mesothelial cells and macrophages from malignant epithelial cells by light microscopy. With in vitro tissue culture technics, the fibroblastic dedifferentiation of mesothel...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Monif GR,Daly JW

    更新日期:1975-07-01 00:00:00

  • Association of estrogen and progestin potency of oral contraceptives with ovarian carcinoma risk.

    abstract:OBJECTIVE:To estimate the association of the estrogen and progestin potency of combined oral contraceptive pills (OCPs) with epithelial ovarian carcinoma risk. METHODS:This population-based case-control study included 745 women with incident, histologically confirmed epithelial ovarian carcinoma and 943 controls, matc...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Lurie G,Thompson P,McDuffie KE,Carney ME,Terada KY,Goodman MT

    更新日期:2007-03-01 00:00:00

  • Postoperative fatigue negatively impacts the daily lives of patients recovering from hysterectomy.

    abstract:OBJECTIVE:To assess, from the patient's perspective, the prevalence and impact of postoperative fatigue after hysterectomy and to increase understanding of physician-patient communications before and after surgery regarding recovery and diminished postoperative energy level. METHODS:We completed a telephone survey of ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: DeCherney AH,Bachmann G,Isaacson K,Gall S

    更新日期:2002-01-01 00:00:00

  • Chemotherapy, Radiation, or Combination Therapy for Stage III Uterine Cancer.

    abstract:OBJECTIVE:To compare the outcomes of women with stage III uterine cancer treated with chemotherapy alone, external beam radiation alone, and combination chemotherapy and radiation. METHODS:The National Cancer Database was used to identify women with stage III endometrioid, serous, and clear cell uterine cancer treated...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Syeda S,Chen L,Hou JY,Tergas AI,Khoury-Collado F,Melamed A,St Clair CM,Ananth CV,Neugut AI,Hershman DL,Wright JD

    更新日期:2019-07-01 00:00:00

  • Successful spontaneous vaginal delivery during mechanical ventilatory support for the adult respiratory distress syndrome.

    abstract::The adult respiratory distress syndrome is a common cause of acute hypoxemic respiratory failure in the adult that is associated with a high mortality. There is a limited experience with managing this entity in the gravid patient. A case of successful management of mother and fetus through spontaneous delivery is pres...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Sosin D,Krasnow J,Moawad A,Hall JB

    更新日期:1986-09-01 00:00:00

  • Comparison of fetal and neonatal growth curves in detecting growth restriction.

    abstract:OBJECTIVE:To evaluate the outcome of intrauterine growth restriction (IUGR) infants with abnormal pulsatility index of the umbilical artery according to the neonatal birth weight/gestational age standards and the intrauterine growth charts. METHODS:We analyzed 53 pregnancies with severe IUGR classified as group 2 (22 ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Marconi AM,Ronzoni S,Bozzetti P,Vailati S,Morabito A,Battaglia FC

    更新日期:2008-12-01 00:00:00

  • Advising and Interview Patterns of Medical Students Pursuing Obstetrics and Gynecology Residency.

    abstract:OBJECTIVE:To describe the advising practices at medical schools and interview patterns among medical students pursuing obstetrics and gynecology residency training. METHODS:A voluntary, anonymous survey was distributed to all applicants interviewing for obstetrics and gynecology residency during the 2014-2015 cycle at...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Alston MJ,Autry AM,Wagner SA,Allshouse AA,Stephenson-Famy A

    更新日期:2016-10-01 00:00:00

  • Malignant mixed müllerian tumor of the uterus arising in association with a viable gestation.

    abstract::Malignant mixed müllerian tumors of the uterus are rare neoplasms occurring predominantly in postmenopausal women. We report the prenatal course and diagnosis of a stage III malignant mixed müllerian tumor at cesarean section in a 35-year-old woman. Despite aggressive radiation and chemotherapy, the patient died 14 we...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Scioscia AL,Merino MJ,Haas M,Copel JA,Schwartz PE

    更新日期:1988-06-01 00:00:00

  • Anal sphincter function after delivery rupture.

    abstract::Questionnaires were sent to 63 women with anal sphincter rupture that occurred during vaginal delivery two to seven years earlier. Half of them had significant trouble, such as incontinence for gas, dyspareunia, and pain. We performed anal pressure profilometry in 14 of these women and in ten controls for comparison, ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Haadem K,Dahlstrom JA,Ling L,Ohrlander S

    更新日期:1987-07-01 00:00:00

  • Therapeutic abortion in Maryland, 1968-1970.

    abstract::The effect of reporting therapeutic abortions in Maryland from 1968-1970 to assess the impact of the new abortion law, which was a liberalization of the previous law, is discussed. All hospitals in the state were required to report on all abortions performed. In fiscal year 1969, 2134 abortions were performed, while...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Melton RJ,Seegar JK Jr,Pitts JL

    更新日期:1972-06-01 00:00:00

  • A lesson in empathy.

    abstract::The author recounts her recent "high-risk" pregnancy. She relates the feelings experienced by many women in this situation, with the added insights of a certified nurse midwive. The author observes how these insights can be applied by health professionals who deliver care to expectant families. ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: McNatt NL

    更新日期:1980-07-01 00:00:00

  • Risk of Subsequent Ovarian Cancer After Ovarian Conservation in Young Women With Stage I Endometrioid Endometrial Cancer.

    abstract:OBJECTIVE:To examine the cumulative incidence of subsequent ovarian cancer among young women with stage I endometrioid endometrial cancer who had ovarian conservation at surgical treatment. METHODS:This retrospective study examined the Surveillance, Epidemiology, and End Results Program to identify women aged younger ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Matsuo K,Machida H,Stone RL,Soliman PT,Thaker PH,Roman LD,Wright JD

    更新日期:2017-08-01 00:00:00

  • Gynecologic Care in Women With Down Syndrome: Findings From a National Registry.

    abstract:OBJECTIVE:To estimate receipt of recommended gynecologic care, including cancer screening and menstrual care, among women with Down syndrome in the United States. METHODS:We conducted a retrospective cohort study of women participating in DS-Connect, the National Institute of Health's registry of women with Down syndr...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Smith AJB,Applebaum J,Tanner EJ,Capone GT

    更新日期:2020-09-01 00:00:00

  • Uterine rupture after uterine artery embolization for symptomatic leiomyomas.

    abstract:BACKGROUND:There are few data regarding safety of pregnancy after uterine artery embolization. However, numerous women desire future fertility after this procedure. Uterine rupture without a history of cesarean delivery or uterine scarring is an exceedingly rare complication in pregnancy. CASE:We report a case of uter...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Yeaton-Massey A,Loring M,Chetty S,Druzin M

    更新日期:2014-02-01 00:00:00

  • Hysteroscopic morcellation compared with electrical resection of endometrial polyps: a randomized controlled trial.

    abstract:OBJECTIVE:To evaluate whether hysteroscopic morcellation or bipolar electrosurgical resection is more favorable for removing endometrial polyps in an office setting in terms of feasibility, speed, pain, and acceptability. METHODS:A multicenter, single-blind, randomized, controlled trial of office hysteroscopic morcell...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Smith PP,Middleton LJ,Connor M,Clark TJ

    更新日期:2014-04-01 00:00:00

  • Fetal nucleated cells in maternal peripheral blood after delivery in cases of fetomaternal hemorrhage.

    abstract:OBJECTIVE:To determine how long fetal nucleated cells can be detected in maternal peripheral blood after delivery in cases of fetomaternal hemorrhage, using fluorescence in situ hybridization or polymerase chain reaction. METHODS:Nucleated cells with Y chromosomes were analyzed in 90 blood samples using fluorescence i...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Hamada H,Arinami T,Hamaguchi H,Kubo T

    更新日期:1995-03-01 00:00:00

  • Foley Bulb Insertion by Blind Placement Compared With Direct Visualization: A Randomized Controlled Trial.

    abstract:OBJECTIVE:To test the hypothesis that digital placement of a balloon catheter is not inferior to the speculum method in terms of rate of maternal infection. METHODS:In an open-label noninferiority randomized trial, pregnant women who were undergoing induction of labor with unfavorable cervix (less than 3 cm dilated an...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Kuhlmann MJ,Spencer N,Garcia-Jasso C,Singh P,Abdelwahab M,Vaughn M,Marshall K,Prasad N,Soulsby-Monroy R,Saade GR,Saad AF

    更新日期:2021-01-01 00:00:00

  • Laparoscopy in the massively obese female.

    abstract::Fifteen women weighing more than 250 pounds (113.6 kg) underwent laparoscopy. The open technique was used in two patients electively because of repeated pelvic laparotomies through periumbilical incisions. Of the remainder, four had used the closed technique and in nine it was necessary to adopt an open technique. Use...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Holtz G

    更新日期:1987-03-01 00:00:00

  • Change in cervical length after prophylactic cerclage.

    abstract:OBJECTIVE:To determine changes in length of incompetent cervices after cerclage, using transvaginal ultrasound. METHODS:Patients were enrolled in a prospective, observational study under an Institutional Review Board-approved protocol. McDonald or Shirodkar sutures were placed according to physician preference. Pre- a...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Funai EF,Paidas MJ,Rebarber A,O'Neill L,Rosen TJ,Young BK

    更新日期:1999-07-01 00:00:00

  • Immunoblotting and enzyme-linked immunosorbent assay for the diagnosis of pemphigoid gestationis.

    abstract:OBJECTIVES:To investigate the sensitivity of immunoblotting and enzyme-linked immunosorbent assay (ELISA) to detect autoantibodies to bullous pemphigoid antigen 180 in patients with pemphigoid gestationis and to correlate autoantibody serum levels with disease activity. METHODS:In serum samples obtained from 44 pregna...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sitaru C,Powell J,Messer G,Bröcker EB,Wojnarowska F,Zillikens D

    更新日期:2004-04-01 00:00:00

  • Racial and Ethnic Disparities in Maternal and Neonatal Adverse Outcomes in College-Educated Women.

    abstract:OBJECTIVE:To compare composite maternal and neonatal adverse outcomes among women with at least a bachelor's degree by racial and ethnic groups. METHODS:This was a retrospective cohort study using the U.S. vital statistics data sets. We included women with at least a bachelor's degree who delivered a nonanomalous live...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Tanner LD,Chen HY,Sibai BM,Chauhan SP

    更新日期:2020-07-01 00:00:00

  • Intrapartum bacteriuria and postpartum endometritis.

    abstract::Ten gravidas with bacteriuria in the immediate antepartum period subsequently delivered vaginally and did not receive antibiotic therapy. Four of these women developed postpartum endometritis and in three of them, the same Enterobacteriaceae recovered from the urine was present in the endometrial cultures. Of the 1233...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Monif GR

    更新日期:1991-08-01 00:00:00

  • Committee opinion no. 615: Access to contraception.

    abstract::Nearly all U.S. women who have ever had sexual intercourse have used some form of contraception at some point during their reproductive lives. However, multiple barriers prevent women from obtaining contraceptives or using them effectively and consistently. All women should have unhindered and affordable access to all...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审



    更新日期:2015-01-01 00:00:00