Enchancement of deficient pituitary response to luteinizing hormone releasing hormone in patients with primary amenorrhea.

Abstract:

:Although the absence of pituitary response to the luteinizing hormone releasing hormone (LHRH) test has been considered proof of a lesion primarily localized at the pituitary level, the possibility exists that an absent pituitary response may represent only the effect of a chronic deficiency of hypothalamic secretion. To verify this hypothesis, 4 patients with primary amenorrhea, hypogonadotropic hypogonadism, and deficient or absent responses to a 25 mug LHRH rapid IV test were treated with 400 mug LHRH infused in 7 hours during each of 3 successive days. The finding that patients with deficient LH responses to a rapid LHRH test became normally responsive to a second equivalent test after a slow and prolonged treatment with the decapeptide suggests that, in these patients, besides a lesion at the pituitary level, a primary defect at the hypothalamic or higher centers may also be suspected.

journal_name

Obstet Gynecol

authors

Serra GB,Muscatello P,Menini E,Lafuenti G,Caniglia R

subject

Has Abstract

pub_date

1975-05-01 00:00:00

pages

523-6

issue

5

eissn

0029-7844

issn

1873-233X

journal_volume

45

pub_type

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