Cervical intraepithelial neoplasia III: long-term outcome after cold-knife conization with clear margins.

Abstract:

OBJECTIVE:To evaluate the long-term outcome of patients with severe cervical intraepithelial neoplasia or squamous cell carcinoma in situ (CIN III) after cold-knife conization with clear margins. METHODS:A total of 4417 women (mean age 36, range 18-72 years) with histologically confirmed CIN III had cold-knife conization with clear margins at our institution between 1970 and 1994. All patients were followed up with colposcopy, cytology, and pelvic examination for a mean of 18 years (range 5-30years). RESULTS:New high-grade squamous intraepithelial lesions (SILs) (CIN II and III) developed in 15 (0.35%) patients (mean age 35, range 25-65 years) after a median of 107 (range 40-201) months. A total of 4402 (99.65%) patients (mean age 36, range 18-72 years) were free of high-grade SILs after a mean follow-up of 18 (range 5-30) years. High-grade glandular intraepithelial lesions developed in two (0.05%) patients 14 and 17 years after conization. Twelve (0.3%) patients had metachronous vulvar intraepithelial neoplasia (VIN) grade III or vaginal intraepithelial neoplasia (VAIN) grade III, and one (0.02%) patient had invasive vaginal carcinoma 10 years after conization. CONCLUSION:Cold-knife conization with clear margins was an adequate method to definitively treat CIN III.

journal_name

Obstet Gynecol

authors

Reich O,Pickel H,Lahousen M,Tamussino K,Winter R

doi

10.1016/s0029-7844(00)01174-1

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

428-30

issue

3

eissn

0029-7844

issn

1873-233X

pii

S0029-7844(00)01174-1

journal_volume

97

pub_type

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