Cervical intraepithelial neoplasia III: long-term outcome after cold-knife conization with clear margins.


OBJECTIVE:To evaluate the long-term outcome of patients with severe cervical intraepithelial neoplasia or squamous cell carcinoma in situ (CIN III) after cold-knife conization with clear margins. METHODS:A total of 4417 women (mean age 36, range 18-72 years) with histologically confirmed CIN III had cold-knife conization with clear margins at our institution between 1970 and 1994. All patients were followed up with colposcopy, cytology, and pelvic examination for a mean of 18 years (range 5-30years). RESULTS:New high-grade squamous intraepithelial lesions (SILs) (CIN II and III) developed in 15 (0.35%) patients (mean age 35, range 25-65 years) after a median of 107 (range 40-201) months. A total of 4402 (99.65%) patients (mean age 36, range 18-72 years) were free of high-grade SILs after a mean follow-up of 18 (range 5-30) years. High-grade glandular intraepithelial lesions developed in two (0.05%) patients 14 and 17 years after conization. Twelve (0.3%) patients had metachronous vulvar intraepithelial neoplasia (VIN) grade III or vaginal intraepithelial neoplasia (VAIN) grade III, and one (0.02%) patient had invasive vaginal carcinoma 10 years after conization. CONCLUSION:Cold-knife conization with clear margins was an adequate method to definitively treat CIN III.


Obstet Gynecol


Reich O,Pickel H,Lahousen M,Tamussino K,Winter R




Has Abstract


2001-03-01 00:00:00














  • A comparative trial of cefazolin and moxalactam as prophylaxis for preventing infection after abdominal hysterectomy.

    abstract::In a randomized, double-blind clinical trial, 208 women who underwent abdominal hysterectomy received either cefazolin (N = 108) or moxalactam (N = 100) as perioperative antimicrobial prophylaxis. There were no differences between the two groups in rates of serious infection, minor wound infection, standard febrile mo...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tuomala RE,Fischer SG,Muñoz A,Souney PF,Steele L,Polk BF

    更新日期:1985-09-01 00:00:00

  • Relationship of hypertensive disease to abruptio placentae.

    abstract::The purpose of the present retrospective study was to examine the relationship between hypertension and abruptio placentae. Two hundred sixty-five consecutive cases of abruption were reviewed, with an emphasis on the occurrence and severity of hypertensive disease. The results confirm a close relationship between abru...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Abdella TN,Sibai BM,Hays JM Jr,Anderson GD

    更新日期:1984-03-01 00:00:00

  • Predicting fetal acidemia using umbilical venous cord gas parameters.

    abstract:OBJECTIVE:To assess the utility of umbilical cord venous blood gas measures for prediction of umbilical artery pH and base deficit acidemia. METHODS:A retrospective cohort study was conducted of all singletons with valid paired arterial and venous cord gas samples delivered at our institution from January 2006 to Marc...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Cantu J,Szychowski JM,Li X,Biggio J,Edwards RK,Andrews W,Tita ATN

    更新日期:2014-11-01 00:00:00

  • Adnexal masses in pregnancy: surgery compared with observation.

    abstract:OBJECTIVE:To estimate whether the delay of surgery impacts the risk of adverse maternal and fetal outcomes in patients diagnosed with an adnexal mass during pregnancy. METHODS:A review was performed of pregnant patients diagnosed with an adnexal mass 5 cm or greater in diameter. Data collected included age, gravity/pa...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Schmeler KM,Mayo-Smith WW,Peipert JF,Weitzen S,Manuel MD,Gordinier ME

    更新日期:2005-05-01 00:00:00

  • Adherent biofilms in bacterial vaginosis.

    abstract:OBJECTIVE:Bacterial vaginosis is a common infectious disorder. Although known since ancient times, little progress has occurred in identifying causal factors. Our aims were to study the bacterial community structure and the spatial organization of microbiota on the epithelial surfaces of vaginal biopsy specimens. METH...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Swidsinski A,Mendling W,Loening-Baucke V,Ladhoff A,Swidsinski S,Hale LP,Lochs H

    更新日期:2005-11-01 00:00:00

  • Fetoscopic Repair of Meningomyelocele.

    abstract:BACKGROUND:Currently, maternal-fetal surgery for repair of myelomeningocele requires an upper-segment hysterotomy, which likely increases maternal postsurgical risks. If fetoscopic repair of myelomeningocele achieves similar or better fetal outcomes while decreasing maternal risks, it would be a better option. CASE:A ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Belfort MA,Whitehead WE,Shamshirsaz AA,Ruano R,Cass DL,Olutoye OO

    更新日期:2015-10-01 00:00:00

  • Wound Complication Rates After Vulvar Excisions for Premalignant Lesions.

    abstract:OBJECTIVE:To assess the rate of wound complications and evaluate the effectiveness of antibiotic prophylaxis in vulvar wide local excision procedures. METHODS:We performed a single-institution, retrospective cohort study of women undergoing vulvar surgery for premalignant lesions between January 2007 and January 2017....

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Mullen MM,Merfeld EC,Palisoul ML,Massad LS,Woolfolk C,Powell MA,Mutch DG,Thaker PH,Hagemann AR,Kuroki LM

    更新日期:2019-04-01 00:00:00

  • Pregnancy after successful vaginoplasty and cervical stenting for partial atresia of the cervix.

    abstract::We previously reported surgical correction of vaginal agenesis and partial cervical atresia in an 11-year-old girl with amenorrhea and a pelvic mass. This patient, the subject of this report, conceived 7 years later and delivered at term. An abdominal cerclage was placed at 12 weeks' gestation to protect the cervix, a...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Hampton HL,Meeks GR,Bates GW,Wiser WL

    更新日期:1990-11-01 00:00:00

  • Advanced abdominal pregnancy resulting from late uterine rupture.

    abstract:BACKGROUND:Advanced abdominal pregnancy is rare, and one that occurs after uterine rupture with delivery of a viable fetus is exceptional. CASE:A multiparous patient was admitted at 29 weeks of gestation for conservative management of placenta previa. She complained of intermittent abdominal pain, but repeated assessm...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Naim NM,Ahmad S,Siraj HH,Ng P,Mahdy ZA,Razi ZR

    更新日期:2008-02-01 00:00:00

  • Antecedent history as a predictor of surgical cure of urgency symptoms in mixed incontinence.

    abstract:OBJECTIVE:To determine the cure rate of urge incontinence after Burch colposuspension in patients with mixed incontinence diagnosed urodynamically, to determine if cure rates were different when the onset of urge symptoms antedated or postdated the symptoms of stress incontinence, and to propose appropriate preoperativ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Scotti RJ,Angell G,Flora R,Greston WM

    更新日期:1998-01-01 00:00:00

  • Premature ovarian failure.

    abstract::The diagnosis of premature ovarian failure was made in 35 women (ages 17 to 40) with increased concentrations of follicle-stimulating hormone and luteinizing hormone. Three had primary amenorrhea, 29 had secondary amenorrhea (less than one to 15 years), and three had irregular menstrual intervals of less than six mont...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Aiman J,Smentek C

    更新日期:1985-07-01 00:00:00

  • Factors contributing to the accuracy in diagnosing ovarian malignancy by color Doppler ultrasound.

    abstract:OBJECTIVE:To determine whether resistance index values obtained by color Doppler ultrasound contribute to the accuracy in diagnosing ovarian malignancies. METHODS:Four hundred ten patients with ovarian neoplasms referred for color Doppler ultrasound evaluation were enrolled, excluding patients examined during the lute...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Wu CC,Lee CN,Chen TM,Lai JI,Hsieh CY,Hsieh FJ

    更新日期:1994-10-01 00:00:00

  • Computerized prenatal genetic testing decision-assisting tool: a randomized controlled trial.

    abstract:OBJECTIVE:Guidelines for fetal aneuploidy testing recommend that screening and diagnostic testing be made available to pregnant women of all ages and that providers explain the differences between these tests to help their patients make informed testing decisions. We sought to estimate the effect of a computerized, int...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验


    authors: Kuppermann M,Norton ME,Gates E,Gregorich SE,Learman LA,Nakagawa S,Feldstein VA,Lewis J,Washington AE,Nease RF Jr

    更新日期:2009-01-01 00:00:00

  • The effect of double gloving on frequency of glove perforations.

    abstract:OBJECTIVE:The purposes of this prospective investigation were to determine the frequency of glove perforation during obstetric and gynecologic procedures and to assess the value of double gloving in preventing damage to the inner glove. METHODS:During a 2-month period, surgeons in the Department of Obstetrics and Gyne...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Bennett B,Duff P

    更新日期:1991-12-01 00:00:00

  • Intrauterine growth retarded infants. Correlation of gestational age with maternal factors, mode of delivery, and perinatal survival.

    abstract::Fifty-eight infants of 3332 deliveries (1.7%) were found to be growth retarded (IGR) at birth. For purposes of analysis, the infants were divided into 2 groups according to gestational age at delivery: Group I infants were delivered between 38 and 43 weeks' gestation, and Group II infants were delivered between 28 and...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Perry CP,Harris RE,DeLemos RA,Null DM Jr

    更新日期:1976-08-01 00:00:00

  • Chorionic villus sampling: transabdominal versus transcervical approach in more than 4000 cases.

    abstract:OBJECTIVE:To address the evolving trends in the choice of transabdominal or transcervical chorionic villus sampling (CVS) at a teaching hospital and to evaluate the influence of gestational age on the approach chosen. METHODS:We analyzed our CVS data base, which contained information from 1986-1991. The proportions of...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Hallak M,Johnson MP,Pryde PG,Isada NB,Zador IE,Evans MI

    更新日期:1992-09-01 00:00:00

  • Methotrexate treatment of unruptured ectopic pregnancy: a report of 100 cases.

    abstract::In an ongoing clinical trial, 100 patients with an unruptured ectopic pregnancy of 3.5 cm or less in greatest dimension were treated with an outpatient protocol of methotrexate and citrovorum factor chemotherapy. Methotrexate and citrovorum were given on alternating days until the hCG titer had decreased by 15% on 2 c...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Stovall TG,Ling FW,Gray LA,Carson SA,Buster JE

    更新日期:1991-05-01 00:00:00

  • ACOG Committee Opinion No. 731 Summary: Group Prenatal Care.

    abstract::Individual prenatal care is intended to prevent poor perinatal outcomes and provide education to women throughout pregnancy, childbirth, and the postpartum period through a series of one-on-one encounters between a woman and her obstetrician or other obstetric care provider. Concerns regarding increasing health care c...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,实务指引



    更新日期:2018-03-01 00:00:00

  • Ability of normal vaginal flora to produce detectable phosphatidylglycerol in amniotic fluid in vitro.

    abstract:OBJECTIVE:To determine if bacteria are capable of producing phosphatidylglycerol in amniotic fluid (AF) and the number of colony forming units (CFU) of bacteria necessary to produce this result. METHODS:Eleven species of bacteria and one species of yeast, common to the female genital tract and implicated in chorioamni...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Lambers DS,Brady K,Leist PA,Setser C,Helmchen R

    更新日期:1995-05-01 00:00:00

  • Prevalence of urinary incontinence and associated risk factors in postmenopausal women. Heart & Estrogen/Progestin Replacement Study (HERS) Research Group.

    abstract:OBJECTIVE:To determine the prevalence of stress, urge, and mixed urinary incontinence and associated risk factors in postmenopausal women. METHODS:Before enrollment in a 4-year, randomized trial of combination hormone therapy to prevent coronary heart disease, 2763 participants completed questionnaires on prevalence a...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Brown JS,Grady D,Ouslander JG,Herzog AR,Varner RE,Posner SF

    更新日期:1999-07-01 00:00:00

  • ACOG Committee Opinion No. 751 Summary: Labor and Delivery Management ofWomenWith Human Immunodeficiency Virus Infection.

    abstract::This Committee Opinion is being revised to provide updated guidance on the management of pregnant women during pregnancy and delivery to prevent mother-to-child transmission of the human immunodeficiency virus (HIV). Prevention of transmission of HIV from the woman to her fetus or newborn is a major goal in the care o...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,实务指引



    更新日期:2018-09-01 00:00:00

  • Determinants of survival of surgically staged patients with endometrial carcinoma histologically confined to the uterus: implications for therapy.

    abstract:OBJECTIVE:To determine the factors that influence the survival of patients with endometrial carcinoma histologically confined to the uterus. METHODS:Retrospective analysis was conducted of 262 surgically staged cases using multiple regression (Cox proportional hazards model). RESULTS:After excluding patients with cle...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Kadar N,Malfetano JH,Homesley HD

    更新日期:1992-10-01 00:00:00

  • Retained viable single intrauterine pregnancy after vacuum aspiration for a dichorionic-diamniotic twin pregnancy.

    abstract:BACKGROUND:Retained viable intrauterine pregnancy is an infrequent complication of vacuum aspiration. We report a case of a retained single intrauterine pregnancy after an elective vacuum aspiration of a dichorionic-diamniotic twin gestation. CASE:A patient presented to the emergency department reporting vaginal spott...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Asemota OA,Podolsky ML

    更新日期:2010-08-01 00:00:00

  • Amniotic fluid index and single deepest pocket: weak indicators of abnormal amniotic volumes.

    abstract:OBJECTIVE:To compare amniotic fluid index (AFI) with the single deepest pocket in the identification of actual abnormal amniotic fluid (AF) volumes. METHODS:One hundred seventy-nine women with singleton pregnancies at the University of Mississippi between March 1994 and June 1999 had ultrasound estimations of AF volum...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Magann EF,Chauhan SP,Barrilleaux PS,Whitworth NS,Martin JN

    更新日期:2000-11-01 00:00:00

  • Plasma Concentrations of Tranexamic Acid in Postpartum Women After Oral Administration.

    abstract:OBJECTIVE:To evaluate the pharmacokinetics of tranexamic acid after oral administration to postpartum women. METHODS:We conducted a single-center pharmacokinetic study at Teaching Hospital-Jaffna, Sri Lanka, on 12 healthy postpartum women who delivered vaginally. After oral administration of 2 g of immediate-release t...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章


    authors: Muhunthan K,Balakumar S,Navaratnaraja TS,Premakrishna S,Arulkumaran S

    更新日期:2020-04-01 00:00:00

  • Storage of newborn stem cells for future use.

    abstract::Human placental cord blood contains a large number of hematopoietic progenitor cells, which could be used as a source of stem cells for the treatment of hematologic disorders and malignancies. Advantages of cord blood use include noninvasive collection, low risk for viral infection, and immunologic naivete. Cord blood...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Wiley JM,Kuller JA

    更新日期:1997-02-01 00:00:00

  • The significance of fetal heart rate reactivity with a positive oxytocin challenge test.

    abstract::This study reviews 27 patients with positive OCTs who were subsequently allowed a trial of directly monitored labor. Of these, 19 patients (70%) developed FHR signs of fetal distress and 8 (30%) tolerated labor without late decelerations. These patients were evaluated for signs of fetal reactivity (acceleration of the...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Braly P,Freeman RK

    更新日期:1977-12-01 00:00:00

  • Rethinking Prenatal Screening for Anomalies of Placental and Umbilical Cord Implantation.

    abstract::The most common anomalies of implantation of the placenta and umbilical cord include placenta previa, placenta accreta spectrum, and vasa previa, and are associated with considerable perinatal and maternal morbidity and mortality. There is moderate quality evidence that prenatal diagnosis of these conditions improves ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Jauniaux E,Silver RM

    更新日期:2020-12-01 00:00:00

  • First- and second-trimester evaluation of risk for Down syndrome.

    abstract:OBJECTIVE:To investigate the differences in costs and outcomes of Down syndrome screening using data from the First and Second Trimester Evaluation of Risk (FASTER) Trial. METHODS:Seven possible screening options for Down syndrome were compared: 1) Triple Screen-maternal serum alpha fetoprotein, estriol, and hCG; 2) Q...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Ball RH,Caughey AB,Malone FD,Nyberg DA,Comstock CH,Saade GR,Berkowitz RL,Gross SJ,Dugoff L,Craigo SD,Timor-Tritsch IE,Carr SR,Wolfe HM,Emig D,D'Alton ME,First and Second Trimester Evaluation of Risk (FASTER) Research Consor

    更新日期:2007-07-01 00:00:00

  • Fetal acoustic stimulation as a possible adjunct to diagnostic obstetric ultrasound: a preliminary report.

    abstract::Unfavorable fetal position during diagnostic obstetric ultrasound can interfere with visualization of certain structures, leading to prolonged or repeated examination. Fetal acoustic stimulation induces a fetal startle reflex and an increase in fetal movements. This report describes our experience with fetal acoustic ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Sarno AP Jr,Bruner JP

    更新日期:1990-10-01 00:00:00