Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial.

Abstract:

OBJECTIVE:To determine the effectiveness of ginger for the treatment of nausea and vomiting of pregnancy. METHODS:Women with nausea and vomiting of pregnancy, who first attended an antenatal clinic at or before 17 weeks' gestation, were invited to participate in the study. During a 5-month period, 70 eligible women gave consent and were randomized in a double-masked design to receive either oral ginger 1 g per day or an identical placebo for 4 days. Subjects graded the severity of their nausea using visual analog scales and recorded the number of vomiting episodes in the previous 24 hours before treatment, and again during 4 consecutive days while taking treatment. At a follow-up visit 7 days later, five-item Likert scales were used to assess the severity of their symptoms. RESULTS:All participants except three in the placebo group remained in the study. The visual analog scores of posttherapy minus baseline nausea decreased significantly in the ginger group (2.1 +/- 1.9) compared with the placebo group (0.9 +/- 2.2, P =.014). The number of vomiting episodes also decreased significantly in the ginger group (1.4 +/- 1.3) compared with the placebo group (0.3 +/- 1.1, P <.001). Likert scales showed that 28 of 32 in the ginger group had improvement in nausea symptoms compared with 10 of 35 in the placebo group (P <.001). No adverse effect of ginger on pregnancy outcome was detected. CONCLUSION:Ginger is effective for relieving the severity of nausea and vomiting of pregnancy.

journal_name

Obstet Gynecol

authors

Vutyavanich T,Kraisarin T,Ruangsri R

doi

10.1016/s0029-7844(00)01228-x

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

577-82

issue

4

eissn

0029-7844

issn

1873-233X

pii

S002978440001228X

journal_volume

97

pub_type

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