Abstract：
OBJECTIVE:To compare the pharmacokinetics of vaginal and oral administration of the prostaglandin E1 analogue, misoprostol. METHODS:Twenty women received 400-micrograms doses of misoprostol either orally or as tablets placed in the vagina. Serum levels of principal metabolite, misoprostol acid, were measured at 7.5, 15, 30, 45, 60, 90, 120, and 240 minutes. The first ten women were pregnant and undergoing first-trimester abortions, and the last ten were not pregnant and had additional blood sampling at 360 minutes. We compared the pharmacokinetics of misoprostol acid after oral and vaginal administration. RESULTS:All 20 subjects completed the study. The maximum mean (+/- standard deviation [SD]) of misoprostol acid differed significantly between the oral and vaginal groups (277 +/- 124 compared with 165 +/d- 86 pg/mL, respectively; P = .03, analysis of variance), as did the mean +/- SD time to peak levels (34 +/- 17 compared with 80 +/- 27 minutes, respectively; P < .001) and areas under the misoprostol concentration versus time curve (mean +/- SD) up to 4 hours (n = 20,273.3 +/- 110.0 compared with 503.3 +/- 296.7 pg.hour/mL, respectively; P = .033) and up to 6 hours (n = 10, 300.0 +/- 103.3 compared with 956.7 +/- 541.7 pg.hour/mL, respectively; P = .029). The extent of absorption was highly variable among subjects in each group. CONCLUSION:There are significant differences in the pharmacokinetics of misoprostol administered by vaginal and oral routes that may explain the difference observed in clinical efficacy. Assuming that the pharmacologic effect of misoprostol is related to its concentration in the plasma, our observation of the prolonged serum concentrations in the vaginal group suggests that vaginal administration could be dosed at longer intervals than oral.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Zieman M,Fong SK,Benowitz NL,Banskter D,Darney PDdoi
10.1016/S0029-7844(97)00111-7subject
Has Abstractpub_date
1997-07-01 00:00:00pages
88-92issue
1eissn
0029-7844issn
1873-233Xpii
S0029-7844(97)00111-7journal_volume
90pub_type
临床试验,杂志文章,随机对照试验abstract：:The treatment of 224 patients with invasive squamous cell carcinoma of the vulva over a 20-year interval at the Mayo Clinic resulted in an overall survival rate of 75%, compared with 89% for age-matched controls. For patients with stage I disease, 5-year survival was 90%; for those with stages II, III, and IV, it was ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:To examine the validity of cervical cytologic diagnosis of sexually transmitted diseases, we reviewed the literature and calculated the efficacy of the Papanicolaou smear as a diagnostic technique. The predictive value of a positive test varied widely, but was generally higher for Trichomonas vaginalis (0.81-1.00) tha...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1987-05-01 00:00:00
abstract：OBJECTIVE:To evaluate whether perioperative indomethacin and antibiotic administration at the time of examination-indicated cerclage placement prolongs gestation. METHODS:This is a randomized controlled trial performed at a single tertiary care hospital between March 2010 and November 2012. Women older than 18 years o...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,随机对照试验
doi：10.1097/AOG.0000000000000228
更新日期：2014-06-01 00:00:00
abstract：:A review of 25 patients with more than 1 rubella titer by hemagglutination-inhibition testing revealed 3 patients with high positive titers that were reported to be negative in subsequent pregnancies. None of the patients had received the rubella vaccine. Because the sensitivity and reliability of hemagglutination-inh...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
abstract：OBJECTIVE:To determine if bacteria are capable of producing phosphatidylglycerol in amniotic fluid (AF) and the number of colony forming units (CFU) of bacteria necessary to produce this result. METHODS:Eleven species of bacteria and one species of yeast, common to the female genital tract and implicated in chorioamni...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0029-7844(95)00032-m
更新日期：1995-05-01 00:00:00
abstract：:There are a number of new genetic tests and a variety of recommendations for obstetrician-gynecologists. In recent years, screening of low-risk pregnant women with noninvasive prenatal testing has been proposed as well as universal BRCA1 and BRCA2 screening of all women regardless of risk status. Both proposed genetic...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000000871
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:To investigate the association between advanced maternal age and adverse pregnancy outcomes and to compare the risks related to advanced maternal age with those related to smoking and being overweight or obese. METHODS:A population-based register study including all nulliparous women aged 25 years and older ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000000062
更新日期：2014-01-01 00:00:00
abstract：:This month, we focus on current research in preterm birth prevention. Dr. Andrews discusses recent publications, and each is concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in on this page, along with direct links to the abstracts. ...
journal_title：Obstetrics and gynecology
pub_type： 评论,杂志文章
doi：10.1097/AOG.0b013e31829e41fc
更新日期：2013-08-01 00:00:00
abstract：:The relation between bodily build and susceptibility to eclampsia has been controversial for nearly two centuries and the issue has been confused by modern studies of women with nonconvulsive hypertensive disorders in whom the diagnosis of preeclampsia is frequently erroneous. The present study is based upon 193 previ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:At puberty, a patient with an imperforate hymen typically presents with a vaginal bulge of thin hymenal tissue with a dark or bluish hue caused by the hematocolpos behind it. Other findings that may be present include an abdominal mass, urinary retention, dysuria, constipation, and dyschezia. On evaluation, the goal i...
journal_title：Obstetrics and gynecology
pub_type： 评论,杂志文章
doi：10.1097/AOG.0000000000003284
更新日期：2019-06-01 00:00:00
abstract：:A woman in her 34th week of gestation required emergency appendectomy for perforation, with postoperative wound dehiscence secondary to fasciitis and tension on the suture line. Polypropylene mesh was used to repair the abdominal wall. Fetal distress necessitated a cesarean section. The mother and child both survived ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:Preoperative abdominopelvic computed tomography results and operative findings were compared in 52 patients undergoing second-look laparotomy to confirm tumor status. Seventeen true-negative, 22 false-negative, and 13 true-positive scans were found. The sensitivity was 0.38, specificity was 1.0, and diagnostic accurac...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1985-05-01 00:00:00
abstract：:A 21-year-old white woman presented with virilization, hirsutism, and acne of 1.5 years' duration. Endocrine testing demonstrated complete suppression of serum testosterone, from 5.3 to 0.6 ng/mL, and serum androstenedione, from 4.7 to 1.7 ng/mL, after oral administration of 50 micrograms of mestranol and 1 mg of nore...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1989-05-01 00:00:00
abstract：:The endocervical strip biopsy instrument obtains strips of endocervical epithelium with attached cervical stroma without excessive bleeding or discomfort to the patient. The intact specimen allows a precise histologic evaluation of endocervical disease processes in patients with abnormal cervical cytology or endometri...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1980-11-01 00:00:00
abstract：OBJECTIVE:To compare a "no touch" approach to diagnostic hysteroscopy without anesthesia with traditional diagnostic hysteroscopy after intracervical injection of mepivacaine hydrochloride 3%. METHODS:A total of 130 women undergoing diagnostic hysteroscopy were included in the study and were randomized, using a comput...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,随机对照试验
doi：10.1097/01.AOG.0000227750.93984.06
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:To determine the factors that influence the survival of patients with endometrial carcinoma histologically confined to the uterus. METHODS:Retrospective analysis was conducted of 262 surgically staged cases using multiple regression (Cox proportional hazards model). RESULTS:After excluding patients with cle...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:The authors attempted to relate neonatal mortality to method of delivery in a series of 345 infants, weighing 700 to 1500 g, who were born in King County, Washington, from 1977 to 1979. Overall, 38% of infants delivered vaginally died as opposed to 32% of those with cesarean births. However, after adjustment for birth...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：:A light microscopic, an electron microscopic, and a ultrahistochemical study have been made of seven placentas from women with mild and excellently controlled chemical gestational diabetes. Only one placenta showed no significant abnormality; the remainder showed, to a varying degree, changes in the syncytiotrophoblas...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1976-09-01 00:00:00
abstract：OBJECTIVE:To determine the safety, tolerability, and efficacy of combination gefitinib and methotrexate to treat ectopic pregnancy. METHODS:We performed a phase I, single-arm (nonrandomized), open-label study. Twelve women with ectopic pregnancies were administered methotrexate (50 mg/m, intramuscular) and 250 mg oral...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e3182a14cfb
更新日期：2013-10-01 00:00:00
abstract：:The hospital-based alternative birth room has become a popular alternative to the conventional labor and delivery room setting. Responses to a mailed questionnaire from 78 of 82 (95%) Washington State hospitals with obstetric services were used to relate available birth options to alternative birth room status and obs...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1981-11-01 00:00:00
abstract：:Ultrasound methods for detecting fetal life during early pregnancy are reviewed. By using recently developed techniques, fetal heart function can be detected as early as the 44th to 45th day of amenorrhea. Fetal movements in the amniotic cavity can be visualized from the 10th week on. If no signs of fetal life can be ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1975-11-01 00:00:00
abstract：:In this study, the concepts of decision theory have been applied to a clinical obstetric controversy--the management of the selected mature breech presentation. We have reviewed in detail the literature published since 1974 and estimated the probabilities of various outcomes after different treatment strategies. We co...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1987-06-01 00:00:00
abstract：:Thirty-eight women with stage I epidermoid carcinoma of the vulva were studied retrospectively in an attempt to define the criteria for conservative therapy in early invasive vulvar cancer. Among the 38 women, 23 met the 6 criteria established for early invasive carcinoma of the vulva. In those 23 women, there were no...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1982-06-01 00:00:00
abstract：OBJECTIVE:The effect of exogenous hormones on the incidence of breast cancer has been extensively studied. Most studies regarding hormonal contraception have focused on combined oral contraceptives, and there is paucity of literature regarding nonoral and progestin-only contraceptives. The present study analyzed the re...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000178754.88912.b9
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:To assess the neurologic and developmental outcome at 2 years of age in preterm infants with birth weights 600 g or lower. METHOD:We conducted a retrospective review from January 1994 through December 1998 for placental histopathology, maternal factors, neonatal intensive care unit course, growth, neurologic...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(02)02451-1
更新日期：2003-01-01 00:00:00
abstract：:Antepartum pituitary infarction occurs only in insulin-dependent diabetic patients. It is manifested by severe headache, followed by decreasing insulin requirements. Delivery is frequently premature, with high fetal wastage and increased maternal mortality. During the puerperium, the first manifestation of pituitary d...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：OBJECTIVE:Women with diabetes need safe, effective contraception. Although intrauterine devices provide superior contraception, concerns remain that progestin absorbed systemically from the levonorgestrel-releasing device may impair carbohydrate metabolism. To examine the effect of the levonorgestrel-releasing intraute...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/01.AOG.0000156301.11939.56
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:To estimate if there were dietary or socioeconomic factors associated with preterm premature rupture of membranes (PROM). METHODS:In this case-control study, women with preterm PROM (n = 46) were compared with healthy pregnant women matched for gestational age and vitamin supplementation. Measurements includ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(02)02380-3
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:To estimate whether and to what extent interbirth interval is associated with cesarean delivery. METHODS:This is a retrospective cohort study of 2,528 multiparous women who presented to labor and delivery at a single tertiary care obstetric hospital during an 18-month period. Women were grouped by their inte...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e31821c4368
更新日期：2011-07-01 00:00:00
abstract：:A simple, rapid, sensitive, and reliable ELISA test for the detection of urinary human chorionic gonadotropin (hCG) has been developed using penicillinase (EC no. 3.5.2.6) as the label and a microtiter ELISA plate as a solid support for antibody. The results of the test is assessed visually for the dark blue that indi...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1981-02-01 00:00:00
