Gestational Alloimmune Liver Disease: A Devastating Condition Preventable With Maternal Intravenous Immunoglobulin.

Abstract:

BACKGROUND:Gestational alloimmune liver disease, a form of profound liver failure in the newborn, is the main underlying cause of the entity formerly known as neonatal hemochromatosis. Antepartum maternal intravenous immunoglobulin (IVIG) has been shown to prevent gestational alloimmune liver disease, which otherwise has a recurrence risk above 90% in subsequent pregnancies. CASE:A 30-year-old woman, gravida 3 para 0120, presented early in gestation. Her previous pregnancy had been complicated by fetal growth restriction, oligohydramnios, and ultimately fatal fulminant neonatal liver failure. With gestational alloimmune liver disease recognized as the primary diagnosis for the liver failure, we began maternal weekly IVIG therapy. She delivered a healthy newborn at term without evidence of hepatic dysfunction. CONCLUSION:Recognition of gestational alloimmune liver disease enables antepartum treatment that dramatically alters the course of disease.

journal_name

Obstet Gynecol

authors

Anastasio HB,Grundy M,Birsner ML,Blakemore KJ

doi

10.1097/AOG.0000000000001569

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

1092-1094

issue

5

eissn

0029-7844

issn

1873-233X

pii

00006250-201611000-00022

journal_volume

128

pub_type

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