Peritoneal cytology of ovarian cancer patients receiving intraperitoneal therapy: quantitation of malignant cells and response.

Abstract:

:An analysis was performed of malignant and host cells found in peritoneal fluids obtained during intraperitoneal chemotherapy and immunotherapy in patients with ovarian cancer. The concentration of malignant cells and the surgically documented response to the intraperitoneal treatment were correlated. Twenty-three patients were treated with intraperitoneal cisplatin or alpha-2 interferon (rIFN-alpha 2) after persistent carcinoma was documented at second-look laparotomy. Six patients (26%) had a complete response to therapy, and all of these patients had a malignant cell concentration of less than 10(2)cells/cm2/dL. No responses were seen in patients whose initial malignant cell concentration was greater than 10(3)cells/cm2/dL. Among patients treated with intraperitoneal alpha-interferon, five of 11 whose initial concentration of malignant cells was less than 10(2) cells/cm2/dL responded to therapy, whereas none of the patients whose malignant cell concentration was 10(2) cells/cm2/dL or greater responded. In patients treated with intraperitoneal cisplatin, the initial concentration of malignant cells associated with any surgically documented response was less than 10(3)cells/cm2/dL. A host mesothelial reaction was prominent after intraperitoneal alpha-interferon, but not observed in women treated with intraperitoneal cis-platin. The fluctuating pattern of peritoneal white blood cells documented during therapy did not correlate with response. THe evaluation of peritoneal cytology specimens during intraperitoneal chemotherapy should include a quantitative assessment of malignant cells and reactive mesothelial cells in order to reflect more accurately the histologically documented findings. Initial quantitative cytology appears to correlate with the likelihood of a surgically documented response to intraperitoneal therapy.

journal_name

Obstet Gynecol

authors

Sagae S,Berek JS,Fu YS,Chang N,Dauplat J,Hacker NF

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

782-8

issue

5

eissn

0029-7844

issn

1873-233X

journal_volume

72

pub_type

杂志文章
  • Effect of type of anesthesia on blood loss at cesarean section.

    abstract::Halogenated anesthetic agents have been used to supplement nitrous oxide during balanced general anesthesia for cesarean delivery to decrease maternal awareness. However, these agents can interfere with uterine contractility and hence have the potential to increase blood loss at the time of cesarean section. To ascert...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Gilstrap LC 3rd,Hauth JC,Hankins GD,Patterson AR

    更新日期:1987-03-01 00:00:00

  • Lidocaine spray compared with submucosal injection for reducing pain during loop electrosurgical excision procedure: a randomized controlled trial.

    abstract:OBJECTIVE:To examine the effectiveness of lidocaine spray compared with conventional lidocaine submucosal injection during a loop electrosurgical excision procedure (LEEP). METHODS:Women undergoing LEEP for any degrees of cervical intraepithelial neoplasia were invited to participate. The participants were randomly as...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/AOG.0b013e31829d888e

    authors: Vanichtantikul A,Charoenkwan K

    更新日期:2013-09-01 00:00:00

  • Obstetric Care Consensus No. 8 Summary: Interpregnancy Care.

    abstract::Interpregnancy care aims to maximize a woman's level of wellness not just in between pregnancies and during subsequent pregnancies, but also along her life course. Because the interpregnancy period is a continuum for overall health and wellness, all women of reproductive age who have been pregnant regardless of the ou...

    journal_title:Obstetrics and gynecology

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1097/AOG.0000000000003026

    authors:

    更新日期:2019-01-01 00:00:00

  • Practice Bulletin No. 184: Vaginal Birth After Cesarean Delivery.

    abstract::Trial of labor after cesarean delivery (TOLAC) refers to a planned attempt to deliver vaginally by a woman who has had a previous cesarean delivery, regardless of the outcome. This method provides women who desire a vaginal delivery the possibility of achieving that goal-a vaginal birth after cesarean delivery (VBAC)....

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,实务指引

    doi:10.1097/AOG.0000000000002398

    authors:

    更新日期:2017-11-01 00:00:00

  • Variables associated with postoperative deep venous thrombosis: a prospective study of 411 gynecology patients and creation of a prognostic model.

    abstract::Deep venous thrombosis is a major complication following gynecologic surgery. Assessing a patient's risk of developing deep venous thrombosis is important for patient selection and in choosing appropriate prophylactic methods. Four hundred eleven patients undergoing major gynecologic surgery were evaluated prospective...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Clarke-Pearson DL,DeLong ER,Synan IS,Coleman RE,Creasman WT

    更新日期:1987-02-01 00:00:00

  • ACOG Committee Opinion No. 731 Summary: Group Prenatal Care.

    abstract::Individual prenatal care is intended to prevent poor perinatal outcomes and provide education to women throughout pregnancy, childbirth, and the postpartum period through a series of one-on-one encounters between a woman and her obstetrician or other obstetric care provider. Concerns regarding increasing health care c...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,实务指引

    doi:10.1097/AOG.0000000000002526

    authors:

    更新日期:2018-03-01 00:00:00

  • Acute intermittent porphyria in pregnancy.

    abstract::A 27-year-old, previously healthy normotensive woman was admitted for hyperemesis gravidarum and treated with intravenous fluids and metoclopramide. Thereafter, a neuropsychiatric syndrome developed, with acute asymmetrical axonal motor-sensory polyneuropathy and marked anxiety, depression, irritability, and memory an...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Milo R,Neuman M,Klein C,Caspi E,Arlazoroff A

    更新日期:1989-03-01 00:00:00

  • Intravenous versus oral iron for treatment of anemia in pregnancy: a randomized trial.

    abstract:OBJECTIVE:The aim of this study was to compare the efficacy of intravenous iron to oral iron in the treatment of anemia in pregnancy. METHODS:In this randomized open-label study, 90 women with hemoglobin levels between 8 and 10.5 g/dL and ferritin values less than 13 microg/L received either oral iron polymaltose comp...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.AOG.0000185260.82466.b4

    authors: Al RA,Unlubilgin E,Kandemir O,Yalvac S,Cakir L,Haberal A

    更新日期:2005-12-01 00:00:00

  • Pituitary response to a new analog of luteinizing hormone releasing factor during the menstrual cycle.

    abstract::A new analog of luteinizing-hormone-releasing factor, (Des-Gly-NH-2-10, Pro-ethylamide-9)-LHRF, was tested in healthy women with regular menstrual cycles. This synthetic nonapeptide amide was injected intravenously in a dose of 200 mug into 15 normal female volunteers in the follicular, preovulatory, and luteal phases...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Nakano R,Takekida H,Kotsuji F,Tojo S

    更新日期:1975-03-01 00:00:00

  • Estradiol, estrone, and gonadotropin levels after use of vaginal estradiol.

    abstract::The vaginal absorption of 0.5-mg tablets of micronized estradiol was evaluated in postmenopausal women. In a single-dose study, one hour after insertion, a 5.3-fold rise in mean serum estradiol levels and 1.5-fold rise in mean serum estrone levels were observed. Mean levels of luteinizing hormone and follicle-stimulat...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Martin PL,Greaney MO,Burnier AM,Brooks PM,Yen SS,Quigley ME

    更新日期:1984-04-01 00:00:00

  • Nodal metastasis risk in endometrioid endometrial cancer.

    abstract:OBJECTIVE:To estimate the risk for nodal metastasis in women with endometrial cancer based on uterine characteristics on pathology. METHODS:From a study of staging for uterine cancer, women were identified as being at low risk for nodal metastasis based on three specific criteria on final pathology reports: 1) less th...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e318240de51

    authors: Milam MR,Java J,Walker JL,Metzinger DS,Parker LP,Coleman RL,Gynecologic Oncology Group.

    更新日期:2012-02-01 00:00:00

  • Rubeola during pregnancy.

    abstract::We report three cases of rubeola during pregnancy complicated by pneumonia. All had bacterial superinfection of the lungs and a clinically mild hepatitis. One woman delivered at term and two underwent successful tocolysis, one of whom had an unexplained stillbirth 7 weeks later. Rubeola virus is not a teratogen, altho...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Stein SJ,Greenspoon JS

    更新日期:1991-11-01 00:00:00

  • Factors associated with worsening and improving urinary incontinence across the menopausal transition.

    abstract:OBJECTIVE:To evaluate whether the menopausal transition is associated with worsening of urinary incontinence symptoms over 6 years in midlife women. METHODS:We analyzed data from 2,415 women who reported monthly or more incontinence in self-administered questionnaires at baseline and during the first six annual follow...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e31816386ce

    authors: Waetjen LE,Feng WY,Ye J,Johnson WO,Greendale GA,Sampselle CM,Sternfield B,Harlow SD,Gold EB,Study of Women's Health Across the Nation (SWAN).

    更新日期:2008-03-01 00:00:00

  • Maternal Racial and Ethnic Disparities in Neonatal Birth Outcomes With and Without Assisted Reproduction.

    abstract:OBJECTIVE:To explore disparities in prematurity and low birth weight (LBW) by maternal race and ethnicity among singletons conceived with and without assisted reproductive technology (ART). METHODS:We performed a retrospective cohort study using resident birth certificate data from Florida, Massachusetts, and Michigan...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000002031

    authors: Crawford S,Joshi N,Boulet SL,Bailey MA,Hood ME,Manning SE,McKane P,Kirby RS,Kissin DM,Jamieson DJ,States Monitoring Assisted Reproductive Technology (SMART) Collaborative.

    更新日期:2017-06-01 00:00:00

  • Prevention of bone mineral loss in postmenopausal women by norethisterone.

    abstract::The effect of norethisterone on bone mineral metabolism was examined in 43 postmenopausal women. A significant decline in serum calcium, phosphate, and alkaline phosphatase in urinary calcium/creatinine ratio and in tubular maximum reabsorption of phosphate was demonstrated. There was no alteration in urinary hydroxyp...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Abdalla HI,Hart DM,Lindsay R,Leggate I,Hooke A

    更新日期:1985-12-01 00:00:00

  • Subspecialty Influence on Scientific Peer Review for an Obstetrics and Gynecology Journal With a High Impact Factor.

    abstract:OBJECTIVE:To evaluate whether quality of peer review and reviewer recommendation differ based on reviewer subspecialty in obstetrics and gynecology and to determine the role of experience on reviewer recommendation. METHODS:We performed a retrospective cohort study of reviews submitted to Obstetrics & Gynecology betwe...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000001852

    authors: Parikh LI,Benner RS,Riggs TW,Hazen N,Chescheir NC

    更新日期:2017-02-01 00:00:00

  • Menstrual cyclicity after metformin therapy in polycystic ovary syndrome.

    abstract:OBJECTIVE:To assess the effect of insulin-lowering treatment on menstrual cyclicity in polycystic ovary syndrome (PCOS). METHODS:Forty oligoamenorrheic women with PCOS were recruited in a prospective clinical study to receive metformin for a minimum period of 6 months. Twenty-two women completed the study. Serum LH, F...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0029-7844(97)00296-2

    authors: Velázquez E,Acosta A,Mendoza SG

    更新日期:1997-09-01 00:00:00

  • Individualized treatment of stage I carcinoma of the vulva.

    abstract::A series of 117 patients with stage I squamous cell carcinoma of the vulva was followed for 3 to 21 years. Twenty recurrences (17.1%) were found, 12 in the vulva or vagina, 7 in the groin, and 1 in a patient who developed distant metastases. Invasion of tumor cells in lymph or blood vessels was found in operative spec...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Iversen T,Abeler V,Aalders J

    更新日期:1981-01-01 00:00:00

  • Poststerilization regret: findings from the United States Collaborative Review of Sterilization.

    abstract:OBJECTIVE:To evaluate the cumulative probability of regret after tubal sterilization, and to identify risk factors for regret that are identifiable before sterilization. METHODS:We used a prospective, multicenter cohort study to evaluate the cumulative probability of regret within 14 years after tubal sterilization. P...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0029-7844(98)00539-0

    authors: Hillis SD,Marchbanks PA,Tylor LR,Peterson HB

    更新日期:1999-06-01 00:00:00

  • False alarms and pseudo-epidemics: the limitations of observational epidemiology.

    abstract::Most reported associations in observational clinical research are false, and the minority of associations that are true are often exaggerated. This credibility problem has many causes, including the failure of authors, reviewers, and editors to recognize the inherent limitations of these studies. This issue is especia...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e31826af61a

    authors: Grimes DA,Schulz KF

    更新日期:2012-10-01 00:00:00

  • Low-dose carbenicillin prophylaxis for vaginal and abdominal hysterectomy.

    abstract::A double-blind prospective study of 99 patients undergoing vaginal and abdominal hysterectomy was performed at North Carolina Baptist Hospital of the Bowman Gray School of Medicine at Wake Forest University. The study indicated that low-dose intravenous carbenicillin begun preoperatively and continued for 24 hours res...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Roberts JM,Homesley HD

    更新日期:1978-07-01 00:00:00

  • Cecal volvulus in pregnancy.

    abstract::Cecal volvulus in pregnancy is an uncommon complication. A case is reported of a 28-year-old white female, gravida 2, para 1, who presented at 36 weeks' gestation with flu-like symptoms accompanied by regular uterine contractions every 3 minutes; she underwent repeat cesarean section without incident. The patient did ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Pratt AT,Donaldson RC,Evertson LR,Yon JL Jr

    更新日期:1981-06-01 00:00:00

  • Transvaginal Doppler assessment of fetal intracranial venous flow.

    abstract:OBJECTIVE:To investigate physiologic blood-flow-velocity waveform patterns of the fetal cerebral venous system during normal pregnancies by transvaginal Doppler studies and to evaluate cases with abnormal venous-flow patterns. METHODS:Internal cerebral veins and the three dural sinuses, those of the superior sagittal ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(98)00546-8

    authors: Pooh RK,Pooh KH,Nakagawa Y,Maeda K,Fukui R,Aono T

    更新日期:1999-05-01 00:00:00

  • Newly diagnosed adult-onset Still disease in pregnancy.

    abstract:BACKGROUND:Adult-onset Still disease is a rare febrile disorder that can present for the first time during pregnancy. It is a diagnosis of exclusion with nonspecific laboratory results. Good maternal and fetal outcomes can be expected after initial diagnosis and treatment. CASE:A 21-year-old (gravida 2, para 1) at 20 ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(03)00065-6

    authors: Pan VL,Haruyama AZ,Guberman C,Kitridou RC,Wing DA

    更新日期:2003-05-01 00:00:00

  • The effects of nonsteroidal antiinflammatory compounds on fetal circulation and pulmonary function.

    abstract::Nonsteroidal antiinflammatory compounds that act by inhibiting synthesis of prostaglandins from arachidonic acid have been shown to have various and sometimes profound effects on fetal and neonatal circulation. Agents such as acetylsalicylic acid, indomethacin, and naproxen pass readily across the placenta and have be...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Rudolph AM

    更新日期:1981-11-01 00:00:00

  • Pregnancy complicated by cyclic vomiting syndrome.

    abstract:BACKGROUND:Cyclic vomiting syndrome is a condition that consists of recurrent episodes of vomiting occurring between periods of normal health, with no apparent organic cause of vomiting. We report the sentinel case of pregnancy complicated by preexisting cyclic vomiting syndrome. CASE:A primigravida presented at 8 wee...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e3181a458e0

    authors: Byers BD,Snyder CH,Saade GR

    更新日期:2009-08-01 00:00:00

  • Acyclovir suppression to prevent cesarean delivery after first-episode genital herpes.

    abstract:OBJECTIVE:To determine if suppressive acyclovir therapy given to term gravidas experiencing a first episode of genital herpes simplex virus (HSV)-infection during pregnancy decreases the need for cesarean delivery for that indication. METHODS:Forty-six pregnant women with first episodes of genital herpes during pregna...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0029-7844(95)00357-6

    authors: Scott LL,Sanchez PJ,Jackson GL,Zeray F,Wendel GD Jr

    更新日期:1996-01-01 00:00:00

  • Inhibition of premature labor by terbutaline.

    abstract::Terbutaline was administered to 50 women, all diagnosed as being in labor prior to 36 weeks' gestation. In 47, uterine activity was initially arrested with intravenous therapy. The infusion rate required to arrest uterine activity ranged from 10 to 80 microgram/min and 21 of the 50 patients (42%) required more than on...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00006250-197804000-00001

    authors: Wallace RL,Caldwell DL,Ansbacher R,Otterson WN

    更新日期:1978-04-01 00:00:00

  • Apgar scores and cognitive performance at 17 years of age.

    abstract::The association between low Apgar scores (7 or less) at 1 and 5 minutes and cognitive performance in late adolescence was assessed. A 17-year follow-up of 1942 subjects was performed. The intelligence test scores at 17 years of age were matched with 1- and 5-minutes Apgar scores. A multiple linear regression analysis ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Seidman DS,Paz I,Laor A,Gale R,Stevenson DK,Danon YL

    更新日期:1991-06-01 00:00:00

  • Porencephaly secondary to fetal trauma during amniocentesis.

    abstract:BACKGROUND:There has been one reported case of porencephaly diagnosed postnatally as a result of amniocentesis. We report the first antenatal diagnosis of porencephaly, which apparently resulted from penetration of the fetal skull during amniocentesis. CASE:A 37-year-old woman had genetic amniocentesis at 16 weeks' ge...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0029-7844(94)00315-5

    authors: Eller KM,Kuller JA

    更新日期:1995-05-01 00:00:00