Cell-mediated cytotoxicity in preinvasive and invasive squamous cell carcinoma of the cervix.

Abstract:

:Cell-mediated immunity was tested by coincubation of target cell line (2043) of human squamous cell carcinoma and peripheral blood leukocytes (PBL) of 22 patients with squamous cell neoplasia of the uterine cervix, 9 patients with other tumors, and 9 normal females. The percentage of cell reduction in mild dysplasia was 90.1 +/- 6.8% (.001 less than P less than .005), in moderate dysplasia was 91.1 +/- 6.4% (.001 less than P less than .005), in severe dysplasia was 91.6 +/- 15.6% (P less than .001), in carcinoma in situ was 85.0 +/ 2.6% (P less than .001), and in invasive squamous cell carcinoma of the cervix was 85.0 +/- 6.9% (P less than .001). Peripheral blood leukocytes of patients with squamous neoplasia did not show any significant cytocoxicity against cell line SKOV-3, developed from an ovarian adenocarcinoma, nor did the PBL of patients with "other tumors" show any significant cytotoxicity against cell line 2043. This study shows that even in early stages of preinvasive squamous cell carcinoma of the cervix, the PBL are sensitized against the neoplastic process, confirming that different stages of cervical intraepithelial neoplasia and invasive squamous cell carcinoma are different intensities of the same biologic process.

journal_name

Obstet Gynecol

authors

Dini MM,Jafari K,Faiferman I

subject

Has Abstract

pub_date

1980-06-01 00:00:00

pages

728-31

issue

6

eissn

0029-7844

issn

1873-233X

journal_volume

55

pub_type

杂志文章
  • Embryonic death in early pregnancy: a new look at the first trimester.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Goldstein SR

    更新日期:1994-08-01 00:00:00

  • Serum 17 alpha-hydroxyprogesterone in patients with gestational trophoblastic neoplasms.

    abstract::Serum 17alpha-hydroxprogesterone (17-OHP), progesterone (P), and human chorionic gonadotropin (hCG) levels were measured by specific radioimmunoassay in 19 patients undergoing laparoscopy or laparotomy with either unevacuated molar pregnancy or nonmetastatic gestational trophoblastic neoplasms (GTN), in 10 normal preg...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Osathanondh R,Goldstein DP,Tulchinsky D,Finn AE

    更新日期:1977-01-01 00:00:00

  • Late meconium passage in labor--a sign of fetal distress?

    abstract::Although the passage early in labor of thick amniotic fluid heavily stained with meconium is recognized as an indication of potential fetal asphyxia, the significance of late passage of meconium-stained fluid in labor is less certain. One hundren twenty-eight patients with late passage of meconium in labor and 134 con...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Meis PJ,Hobel CJ,Ureda JR

    更新日期:1982-03-01 00:00:00

  • ACOG Committee Opinion No. 751 Summary: Labor and Delivery Management ofWomenWith Human Immunodeficiency Virus Infection.

    abstract::This Committee Opinion is being revised to provide updated guidance on the management of pregnant women during pregnancy and delivery to prevent mother-to-child transmission of the human immunodeficiency virus (HIV). Prevention of transmission of HIV from the woman to her fetus or newborn is a major goal in the care o...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,实务指引

    doi:10.1097/AOG.0000000000002821

    authors:

    更新日期:2018-09-01 00:00:00

  • Immunomodulation in women with endometriosis receiving GnRH agonist.

    abstract:OBJECTIVE:To assess the changes in the subpopulations of lymphocytes and in lymphocyte mitogenic activity in women with endometriosis receiving GnRH-agonist treatment. METHODS:Twenty-six women with advanced endometriosis from the National Cheng Kung University Medical College were studied. Each received a total of six...

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    pub_type: 临床试验,杂志文章

    doi:10.1016/s0029-7844(97)00145-2

    authors: Hsu CC,Lin YS,Wang ST,Huang KE

    更新日期:1997-06-01 00:00:00

  • Mesenteric supernumerary ovary.

    abstract::Following is a report and a review of literature concerning the supernumerary ovary. Up to now only 7 cases have been reported, and our case appears to be the eighth. The anatomic situation in this case was unusual since it was found in the mesentery. Of the cases previously reported, 2 have been associated with benig...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Abrego D,Ibrahim AA

    更新日期:1975-03-01 00:00:00

  • Uterine contraction pressures with oxytocin induction/augmentation.

    abstract::Uterine contraction pressures were quantified (in Montetevideo units) in 109 women at term gestation who received oxytocin for induction or augmentation of labor and whose labor resulted in a spontaneous vaginal delivery. Newborn five-minute Apgar scores were greater than or equal to 8 in 108 of the 109 neonates, and ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00006250-198609000-00003

    authors: Hauth JC,Hankins GD,Gilstrap LC 3rd,Strickland DM,Vance P

    更新日期:1986-09-01 00:00:00

  • Management of shoulder dystocia: trends in incidence and maternal and neonatal morbidity.

    abstract:OBJECTIVE:To investigate trends in the incidence of shoulder dystocia, methods used to overcome the obstruction, and rates of maternal and neonatal morbidity. METHODS:Cases of shoulder dystocia and of neonatal brachial plexus injury occurring from 1991 to 2005 in our unit were identified. The obstetric notes of cases ...

    journal_title:Obstetrics and gynecology

    pub_type: 评论,杂志文章

    doi:10.1097/01.AOG.0000287615.35425.5c

    authors: MacKenzie IZ,Shah M,Lean K,Dutton S,Newdick H,Tucker DE

    更新日期:2007-11-01 00:00:00

  • Clinical applications of cell-free fetal DNA from maternal plasma.

    abstract:OBJECTIVE:To describe our clinical experience with detection and analysis of cell-free fetal DNA derived from maternal plasma for prenatal sexing and fetal rhesus-D typing. METHODS:Real-time quantitative polymerase chain reactions (PCRs) of rhesus-D sequences and the SRY gene were validated and offered to patients wit...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000103996.44503.F1

    authors: Rijnders RJ,Christiaens GC,Bossers B,van der Smagt JJ,van der Schoot CE,de Haas M

    更新日期:2004-01-01 00:00:00

  • Metabolic parameters and steroid levels in postmenopausal women receiving lower doses of natural estrogen replacement.

    abstract::This study was carried out to determine whether some of the lowest doses of natural estrogens currently prescribed for postmenopausal women result in significant changes in plasma lipids, urinary calcium, urinary free cortisol, or level of androgens. Twenty-four postmenopausal women were studied and the estrogens inge...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Lobo RA,Brenner P,Mishell DR Jr

    更新日期:1983-07-01 00:00:00

  • Clinical and pathologic correlation of endometrial cavity fluid detected by ultrasound in the postmenopausal patient.

    abstract::A registry of ultrasound procedures spanning nearly 5 years was searched retrospectively to discover cases of endometrial cavity fluid collections in postmenopausal women. Twenty cases were identified; all medical records were available for review. One patient was lost to follow-up. Seventeen patients had surgical pro...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Carlson JA Jr,Arger P,Thompson S,Carlson EJ

    更新日期:1991-01-01 00:00:00

  • Amniotic fluid optical density and neonatal respiratory outcome.

    abstract::A simple, rapid, economical, and accurate test to assess fetal pulmonary maturity on a 24-hour basis, 7 days a week, is urgently needed. A 15-minute test has been developed that correlates well with fetal pulmonary maturity. Optical density (OD) readings at 650 nm of greater than or equal to 0.15 in pigment-free, cent...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Cetrulo CL,Sbarra AJ,Selvaraj RJ,Kappy KA,Herschel MJ,Knuppel RJ,Ingardia CJ,Kennedy JL,Mitchell GW

    更新日期:1980-02-01 00:00:00

  • Evidence of poorer survival in pregnancy-associated breast cancer.

    abstract:OBJECTIVE:To compare stage distribution, tumor characteristics, and survival outcome in pregnancy-associated and non-pregnancy-associated breast cancer, and to evaluate pregnancy as a risk factor for mortality in breast cancer. METHODS:The California Cancer Registry (1991-1999) was linked with the California Patient D...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e31817c4ebc

    authors: Rodriguez AO,Chew H,Cress R,Xing G,McElvy S,Danielsen B,Smith L

    更新日期:2008-07-01 00:00:00

  • High rates of atypical cervical cytology: occurrence and clinical significance.

    abstract::The current literature suggests that atypical (benign atypia or class II) Papanicolaou smears occur at a frequency of 1.6-5.4% and are associated with a substantial rate of underlying cervical dysplasia. However, we noted that our rate of atypia exceeded these figures, particularly in our clinic population. To quantif...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Pearlstone AC,Grigsby PW,Mutch DG

    更新日期:1992-08-01 00:00:00

  • Clinical evaluation of tumor-associated mucin-type glycoprotein CA 54/61 in ovarian cancers: comparison with CA 125.

    abstract::Studies were conducted in 343 women on the clinical utility of the newly developed tumor-associated mucin-type glycoprotein, CA 54/61, as a tumor marker in serum for ovarian cancer. The overall positivity rate of the new marker was 60%, lower than the rate of 88% obtained with CA 125 measured concurrently. Concerning ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Suzuki M,Sekiguchi I,Tamada T

    更新日期:1990-09-01 00:00:00

  • Chlorhexidine-alcohol compared with povidone-iodine for surgical-site antisepsis in cesarean deliveries.

    abstract:OBJECTIVE:To estimate the incidence of surgical-site infection with use of chlorhexidine-alcohol compared with povidone-iodine among women undergoing cesarean deliveries. METHODS:This was a retrospective cohort review of 1,000 consecutive cases in women who underwent cesarean delivery over a 1-year interval. The prima...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/aog.0b013e31826f3bd9

    authors: Menderes G,Athar Ali N,Aagaard K,Sangi-Haghpeykar H

    更新日期:2012-11-01 00:00:00

  • Pregnancy intention and its relationship to birth and maternal outcomes.

    abstract:OBJECTIVE:To examine whether there are associations between pregnancy intention (intended, unwanted, mistimed, or ambivalent) and negative birth and maternal outcomes: low birth weight (less than 2,500 g), preterm delivery (fewer than 37 weeks), small for gestational age, premature labor, hypertension, and other matern...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000255666.78427.c5

    authors: Mohllajee AP,Curtis KM,Morrow B,Marchbanks PA

    更新日期:2007-03-01 00:00:00

  • Rapid B-scan (real-time) ultrasonography in the identification and evaluation of twin pregnancies.

    abstract::Real-time ultrasonography utilizing a hand-held linear array transducer provides a highly accurate method of identifying and evaluating the twin gestation. The rapidity of real-time scanning eliminates interpretational problems caused by fetal movements. Additionally, the versatility of transducer positioning facilita...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Levine SC,Filly RA

    更新日期:1978-02-01 00:00:00

  • Glycohemoglobin determinations in normal pregnancy and in insulin-dependent diabetics.

    abstract::Minor components of adult hemoglobin (A1a,b, and c) are known to increase in the presence of sustained elevations of maternal blood glucose. This study demonstrates the correlation between glycosylated hemoglobin components and the usual shorter term indices of diabetic control. In addition, a correlation was noted be...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Vintzileos AM,Thompson JP

    更新日期:1980-10-01 00:00:00

  • Postoperative fatigue negatively impacts the daily lives of patients recovering from hysterectomy.

    abstract:OBJECTIVE:To assess, from the patient's perspective, the prevalence and impact of postoperative fatigue after hysterectomy and to increase understanding of physician-patient communications before and after surgery regarding recovery and diminished postoperative energy level. METHODS:We completed a telephone survey of ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(01)01622-2

    authors: DeCherney AH,Bachmann G,Isaacson K,Gall S

    更新日期:2002-01-01 00:00:00

  • Adenomyosis: symptoms, histology, and pregnancy terminations.

    abstract:OBJECTIVE:To correlate symptoms of uterine adenomyosis with histopathologic features. METHODS:One hundred eleven specimens of uteri and cervices that weighed under 280 g were reevaluated. When adenomyosis was identified, assessment included depth of adenomyotic foci, graded as deep (above 80%), intermediate (40-80%), ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(99)00659-6

    authors: Levgur M,Abadi MA,Tucker A

    更新日期:2000-05-01 00:00:00

  • Neonatal cranial osteomyelitis: a complication of fetal monitoring.

    abstract::Use of a scalp electrode facilitates and adds precision to electronic fetal monitoring. We report an instance of neonatal osteomyelitis due to infection of the electrode insertion site. Electrode-associated soft and bony tissue infections are most commonly mediated by cervicovaginal microflora and appear clinically an...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: McGregor JA,McFarren T

    更新日期:1989-03-01 00:00:00

  • The implications of a false positive second-trimester serum screen for Down syndrome.

    abstract:OBJECTIVE:To investigate the genetic and obstetric implications of false positive Down syndrome serum screening results. METHODS:The study population comprised 162774 women underwent triple marker screening in the Ontario Maternal Serum Screening program between October 1995 and September 1998, with outcomes obtained ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(03)00235-7

    authors: Summers AM,Huang T,Meier C,Wyatt PR

    更新日期:2003-06-01 00:00:00

  • Abdominal pregnancy in a low-resource setting.

    abstract:BACKGROUND:Abdominal pregnancies are rare types of ectopic pregnancies with high rates of maternal mortality and morbidity when encountered anywhere in the world. Combining such high-risk pregnancy with the limitations found in a low-resource setting can lead to increased complications, which can be more difficult to m...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000000706

    authors: Lee C

    更新日期:2015-05-01 00:00:00

  • Committee opinion no 611: method for estimating due date.

    abstract::: Accurate dating of pregnancy is important to improve outcomes and is a research and public health imperative. As soon as data from the last menstrual period, the first accurate ultrasound examination, or both are obtained, the gestational age and the estimated due date should be determined, discussed with the patien...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.AOG.0000454932.15177.be

    authors:

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  • Internet availability of contraceptives.

    abstract:OBJECTIVE:To measure the accessibility of contraceptive supplies over the Internet. METHODS:We performed an Internet search with the use of search engines and key words. We posed as consumers purchasing both prescription and over-the-counter contraceptive supplies. The number of clicks or web pages accessed, costs, sh...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(00)01113-3

    authors: Miller L,Nielsen C

    更新日期:2001-01-01 00:00:00

  • Titrated oral compared with vaginal misoprostol for labor induction: a randomized controlled trial.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.AOG.0000297313.68644.71

    authors: Cheng SY,Ming H,Lee JC

    更新日期:2008-01-01 00:00:00

  • Asphyxia and gestational age.

    abstract::Perinatal asphyxia at term is a major cause of mortality and morbidity. In many instances obstetric or maternal complications during pregnancy, labor, or delivery account for the asphyxia, but there is a group of infants in whom asphyxia occurs without any recognizable risk factors. The histories of 1602 infants were ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

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    authors: Grausz JP,Heimler R

    更新日期:1983-08-01 00:00:00

  • Persistence of gestational trophoblastic disease for longer than 1 year following evacuation of hydatidiform mole.

    abstract:BACKGROUND:A spontaneous fall in the radioimmunoassay for the beta subunit of hCG to less than 2 mIU/mL documents regression of hydatidiform mole following evacuation of a molar pregnancy. Continued negative hCG levels for the year after evacuation indicates the absence of risk for persistent gestational trophoblastic ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Elmer DB,Granai CO,Ball HG,Curry SL

    更新日期:1993-05-01 00:00:00

  • Is endometriosis an autoimmune disease?

    abstract::Among 59 laparoscopically staged endometriosis patients, 28.8% tested positive for antinuclear antibody. Of 44 patients, 45.5% were lupus anticoagulant positive (greater than 1.3) and 20.5% were within a borderline range (1.2-1.3). Antinuclear antibody positivity was inversely related to stage of disease (P = .009); l...

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    doi:

    authors: Gleicher N,el-Roeiy A,Confino E,Friberg J

    更新日期:1987-07-01 00:00:00