Estradiol, estrone, and gonadotropin levels after use of vaginal estradiol.

Abstract:

:The vaginal absorption of 0.5-mg tablets of micronized estradiol was evaluated in postmenopausal women. In a single-dose study, one hour after insertion, a 5.3-fold rise in mean serum estradiol levels and 1.5-fold rise in mean serum estrone levels were observed. Mean levels of luteinizing hormone and follicle-stimulating hormone were significantly depressed. In a three-week alternate-day regimen, mean serum levels of estradiol were consistently two to three times greater than those of estrone 12 hours after insertion. Vaginal absorption of micronized estradiol tablets into the systemic circulation was found to be rapid and efficient. The vaginal route was acceptable and well tolerated by patients. In addition, the major conversion of estradiol to estrone that follows oral or sublingual administration was reduced. The vagina may be a preferred alternate route for estrogen replacement therapy in selected patients.

journal_name

Obstet Gynecol

authors

Martin PL,Greaney MO,Burnier AM,Brooks PM,Yen SS,Quigley ME

subject

Has Abstract

pub_date

1984-04-01 00:00:00

pages

441-4

issue

4

eissn

0029-7844

issn

1873-233X

journal_volume

63

pub_type

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