Routine endocrine screening for patients with karyotypically normal spontaneous premature ovarian failure.

Abstract:

OBJECTIVE:To evaluate the usefulness of routine screening for other associated autoimmune endocrine disorders in patients with karyotypically normal spontaneous premature ovarian failure. METHODS:One hundred nineteen women with karyotypically normal spontaneous premature ovarian failure (FSH exceeding 40 mIU/mL) who desired fertility were evaluated at a tertiary care academic center by physical examination, measurement of serum free thyroxine and TSH, ACTH stimulation test, fasting serum glucose, 3-hour glucose tolerance test, measurement of serum electrolytes including total calcium, and measurement of serum vitamin B12. RESULTS:Twenty-two of 119 patients (18.5%) were known to have hypothyroidism and three were known to have Addison disease. Ten new cases of hypothyroidism and three new cases of diabetes mellitus were discovered. However, no new cases of adrenal insufficiency, hypoparathyroidism, or pernicious anemia were found. CONCLUSION:Screening for hypothyroidism and diabetes appears justified in those patients with karyotypically normal spontaneous premature ovarian failure who desire fertility. However, our findings suggest that in these patients, testing for other associated autoimmune endocrine disorders may be reserved for those with clinical indications.

journal_name

Obstet Gynecol

authors

Kim TJ,Anasti JN,Flack MR,Kimzey LM,Defensor RA,Nelson LM

doi

10.1016/s0029-7844(97)00077-x

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

777-9

issue

5 Pt 1

eissn

0029-7844

issn

1873-233X

journal_volume

89

pub_type

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