From Gestational Hypertension and Preeclampsia to Atypical Hemolytic Uremic Syndrome.

Abstract:

BACKGROUND:Preeclampsia is a leading cause of morbidity and mortality during pregnancy. The variability of clinical features suggests that preeclampsia is not a single disease. Atypical hemolytic uremic syndrome, resulting from defective regulation of the alternative complement pathway, is less well known and may be mistaken for preeclampsia. CASE:We describe a woman with atypical hemolytic uremic syndrome who was given the diagnosis of gestational hypertension during her first pregnancy and preeclampsia and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome followed by thrombotic thrombocytopenic purpura and hemolytic uremic syndrome during her second pregnancy, before the correct diagnosis of atypical hemolytic uremic syndrome was recognized in the postpartum period of her third pregnancy. The patient was treated with anticomplement therapy and had a rapid improvement. CONCLUSION:This case illustrates the importance of distinguishing atypical hemolytic uremic syndrome from preeclampsia.

journal_name

Obstet Gynecol

authors

Tsai HM,Kuo E

doi

10.1097/AOG.0000000000001340

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

907-910

issue

5

eissn

0029-7844

issn

1873-233X

pii

00006250-201605000-00014

journal_volume

127

pub_type

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