Serotonin receptor 1A C(-1019)G polymorphism associated with premenstrual dysphoric disorder.

Abstract:

OBJECTIVE:To assess whether the G allele of the serotonin receptor 1A C(-1019)G polymorphism is associated with premenstrual dysphoric disorder. METHODS:The study sample comprised 53 women with clinically diagnosed premenstrual dysphoric disorder (age range 27-46 years, mean 37.7 years) and 51 healthy control subjects (age range 22-48 years, mean 36.2 years). The serotonin receptor 1A C(-1019)G polymorphism was genotyped and compared between the two groups. RESULTS:In contrast to the postulated "high-risk" G/G genotype, there was a marked overrepresentation of the C/C genotype in the premenstrual dysphoric disorder group (P=.034; odds ratio 3.63, 95% confidence interval 1.22-10.78). The presence of at least one C allele was associated with a 2.5-fold increased risk of premenstrual dysphoric disorder (P=.053; odds ratio 2.46, 95% confidence interval 1.03-5.88). CONCLUSION:Our hypothesis that the high-risk G allele is associated with the occurrence of premenstrual dysphoria was not proved in this study. However, due to the increased prevalence of the C variant, we suggest that the C(-1019) allele may contribute to the risk of premenstrual dysphoria. LEVEL OF EVIDENCE:II.

journal_name

Obstet Gynecol

authors

Dhingra V,Magnay JL,O'Brien PM,Chapman G,Fryer AA,Ismail KM

doi

10.1097/01.AOG.0000284448.73490.ac

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

788-92

issue

4

eissn

0029-7844

issn

1873-233X

pii

110/4/788

journal_volume

110

pub_type

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