Paracervical block efficacy in office hysteroscopic sterilization: a randomized controlled trial.

Abstract:

OBJECTIVE:To estimate the efficacy of paracervical block compared with saline for pain relief during office hysteroscopic sterilization. METHODS:This study was a randomized, placebo-controlled study of women desiring hysteroscopic sterilization. A paracervical block of 1% lidocaine or normal saline was administered before office hysteroscopic sterilization. Patients and investigators were blinded to assignments. A pre hoc power analysis determined that 40 women would be required per arm to detect a difference of 0.9 cm on a visual analog scale. Pain was recorded on a visual analog scale at multiple procedure time points. Individualized standardized pain scores were constructed by weighted reporting of objective and subjective sensation. RESULTS:A total of 103 consecutive women were eligible, and 80 women were randomized, with 40 per group. Thirty-seven (93%) in each group had successful placement. The lidocaine group showed significantly lower pain scores for tenaculum placement (mean+/-standard deviation: 0.97+/-1.28 compared with 3.00+/-2.41, P<.001) traversing the external cervical os (1.46+/-1.71 compared with 3.77+/-2.68, P<.001) and internal os (1.79+/-2.11 compared with 4.10+/-2.77, P<.001). There was no significant observed difference with device placement in tubal ostium (3.15+/-2.69 compared with 3.74+/-2.73, P=.33). Multivariable linear regression analysis demonstrated a relationship of pain to procedural time (P=.047) and to group assignment (P<.01). CONCLUSION:Paracervical block with 1% lidocaine provides effective pain relief for cervical manipulations during office hysteroscopic sterilization, but does not reduce the pain associated with upper uterine/tubal manipulation when placing the devices. CLINICAL TRIAL REGISTRATION:ClinicalTrials.gov, www.clinicaltrials.gov, NCT00811187. LEVEL OF EVIDENCE:I.

journal_name

Obstet Gynecol

authors

Chudnoff S,Einstein M,Levie M

doi

10.1097/AOG.0b013e3181c51ace

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

26-34

issue

1

eissn

0029-7844

issn

1873-233X

pii

00006250-201001000-00006

journal_volume

115

pub_type

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