Abstract：
:The effects of ethanol on DNA and protein synthesis of regenerating rat liver has been studied. A single dose of ethanol, when given either before, at the time or 1 h after the partial hepatectomy significantly inhibited the accelerated synthesis of ornithine decarboxylase protein which was used as a marker of protein synthesis. Ethanol seemed to inhibit the synthesis of ornithine decarboxylase at transcriptional level of protein synthesis and the inhibition appeared to be directly due to the presence of ethanol molecules. When rats were chronically fed with ethanol-containing liquid diet also the total protein synthesis was inhibited during the two first days of regeneration. In this experiment also the rate of DNA synthesis was greatly inhibited by ethanol treatment. The results show that the ethanol-induced inhibition of the synthesis of tissue macromolecules is ideally demonstrated in regenerating rat liver. Furthermore they suggest that this effect may be of importance in the progression of alcoholic liver injury.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Pösö R,Pösö H,Väänänen H,Salaspuro Mdoi
10.1007/978-1-4757-1419-7_57subject
Has Abstractpub_date
1980-01-01 00:00:00pages
551-60eissn
0065-2598issn
2214-8019journal_volume
132pub_type
杂志文章abstract：:Human heart rate variability (HRV) was examined during a mild respiratory acidosis induced by inhalation of a normoxic hypercapnic gas mixture. On two separate occasions, separated by 72 but not more than 120hr, ECG was recorded from 9 normotensive subjects during supine rest. ECG was recorded for 20 min breathing roo...
journal_title：Advances in experimental medicine and biology
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更新日期：2011-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-9093-0_9
更新日期：1977-01-01 00:00:00
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doi：10.1007/978-1-4615-5331-1_103
更新日期：1998-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
abstract：:The success rate from investigational new drug filing to drug approval has remained low for decades despite major scientific and technological advances, and a steady increase of funding and investment. The failure to demonstrate drug efficacy has been the major reason that drug development does not progress beyond pha...
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