听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Advances in Experimental Medicine and Biology期刊下所有文献
  • Manual Pressure Release and Low-Grade Electrical Peripheral Receptor Stimulation in Nonspecific Low Back Pain: A Randomized Controlled Trial.

    abstract::Chronic nonspecific low back pain is a frequent clinical condition affecting the general population and influencing disability level and quality of life. We performed a single-blinded, randomized, and controlled study to compare the effectiveness of manual pressure release (MPR) and electrical neuromodulation (ENM) tr...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2020_605

    authors: Barassi G,Pokorski M,Di Matteo C,Supplizi M,Prosperi L,Guglielmi V,Younes A,Della Rovere F,Di Iorio A

    更新日期:2021-01-21 00:00:00

  • Clinical and Neuroimaging Aspects of Familial Frontotemporal Lobar Degeneration Associated with MAPT and GRN Mutations.

    abstract::Numerous kindreds with familial frontotemporal lobar degeneration have been linked to mutations in microtubule-associated protein tau (MAPT) or progranulin (GRN) genes. While there are many similarities in the clinical manifestations and associated neuroimaging findings, there are also distinct differences. In this re...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-030-51140-1_6

    authors: Boeve BF,Rosen H

    更新日期:2021-01-01 00:00:00

  • The Role of the Mediterranean Dietary Pattern on Metabolic Control of Patients with Diabetes Mellitus: A Narrative Review.

    abstract::Diabetes mellitus (DM) is a metabolic disorder characterised by hyperglycemia and abnormalities in carbohydrate, fat and protein metabolism. Several studies demonstrated that foods typical of the Mediterranean diet (MedDiet), including vegetables, fruits, oilseeds, extra virgin olive oil and fish, can promote health b...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/5584_2020_513

    authors: Tosatti JAG,Alves MT,Gomes KB

    更新日期:2021-01-01 00:00:00

  • Histone Lysine-to-Methionine Mutation as Anticancer Drug Target.

    abstract::Histone modification stands for a vital genetic information form, which shows tight correlation with the modulation of normal physiological activities by genes. Abnormal regulation of histone methylation due to histone modification enzyme changes and histone mutations plays an important role in the development of canc...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-15-8104-5_7

    authors: Yang J,Qiu Q,Chen L

    更新日期:2021-01-01 00:00:00

  • The Impact of Notch Signaling for Carcinogenesis and Progression of Nonmelanoma Skin Cancer: Lessons Learned from Cancer Stem Cells, Tumor Angiogenesis, and Beyond.

    abstract::Since many decades, nonmelanoma skin cancer (NMSCs) is the most common malignancy worldwide. Basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) are the major types of NMSCs, representing approximately 70% and 25% of these neoplasias, respectively. Because of their continuously rising incidence rates, NMSCs...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-55031-8_9

    authors: Reichrath J,Reichrath S

    更新日期:2021-01-01 00:00:00

  • Effects of GLP-1 and Its Analogs on Gastric Physiology in Diabetes Mellitus and Obesity.

    abstract::The processing of proglucagon in intestinal L cells results in the formation of glucagon, GLP-1, and GLP-2. The GLP-1 molecule becomes active through the effect of proconvertase 1, and it is inactivated by dipeptidyl peptidase IV (DPP-IV), so that the half-life of endogenous GLP-1 is 2-3 min. GLP-1 stimulates insulin ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/5584_2020_496

    authors: Maselli DB,Camilleri M

    更新日期:2021-01-01 00:00:00

  • Tregs in Autoimmune Uveitis.

    abstract::Uveitis is a chronic disease with relapsing and remitting ocular attack, which requires corticosteroids and systemic immunosuppression to prevent severe vision loss. Classically, uveitis is referred to an autoimmune disease, mediated by pro-inflammatory Th17 cells and immunosuppressive CD4+CD25+FoxP3+ T-regulatory cel...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-15-6407-9_11

    authors: Huang Z,Li W,Su W

    更新日期:2021-01-01 00:00:00

  • Regulatory T Cells: Concept, Classification, Phenotype, and Biological Characteristics.

    abstract::Regulatory T cells (Treg) play an indispensable role in maintaining the body's immune nonresponse to self-antigens and suppressing the body's unwarranted and potentially harmful immune responses. Their absence, reduction, dysfunction, transformation, and instability can lead to numerous autoimmune diseases. There are ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-15-6407-9_1

    authors: Du Y,Fang Q,Zheng SG

    更新日期:2021-01-01 00:00:00

  • Effects of Environment and Lifestyle Factors on Premature Ovarian Failure.

    abstract::Premature ovarian insufficiency (POI) or primary ovarian failure is defined as a cessation of the menstrual cycle in women younger than 40 years old. It is strictly defined as more than 4 months of oligomenorrhea or amenorrhea in a woman <40 years old, associated with at least two follicle-stimulating hormone (FSH) le...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-33-4187-6_4

    authors: Yang Y,Huang W,Yuan L

    更新日期:2021-01-01 00:00:00

  • Neuregulin Signaling in the Tumor Microenvironment.

    abstract::Neuregulins, members of the largest subclass of growth factors of the epidermal growth factor family, mediate a myriad of cellular functions including survival, proliferation, and differentiation in normal tissues through binding to receptor tyrosine kinases of the ErbB family. However, aberrant neuregulin signaling i...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-030-47189-7_1

    authors: Jia R,Zhao H,Wang S

    更新日期:2021-01-01 00:00:00

  • Glucose Lowering Treatment Modalities of Type 2 Diabetes Mellitus.

    abstract::This chapter gives an overview of present knowledge and clinical aspects of antidiabetic drugs according to the recently available research evidence and clinical expertise.Many agents are acting on eight groups of pathophysiological mechanisms, which is commonly called as "Ominous Octet" by DeFronzo. The muscle, liver...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/5584_2020_516

    authors: Gökçay Canpolat A,Şahin M

    更新日期:2021-01-01 00:00:00

  • Optogenetics-Mediated Gene Therapy for Retinal Diseases.

    abstract::The visual system consists of various types of neurons and a single-nucleotide mutation can sometimes lead to blindness. The phototransduction pathway in the retina starts from the first-order neurons, the photoreceptor cells, and transmits the signals to second-order neurons. Finally, the output signal from third-ord...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-15-8763-4_37

    authors: Tomita H,Sugano E

    更新日期:2021-01-01 00:00:00

  • Functional Connectome Analysis of the Striatum with Optogenetics.

    abstract::Neural circuit function is determined not only by anatomical connections but also by the strength and nature of the connections, that is functional or physiological connectivity. To elucidate functional connectivity, selective stimulation of presynaptic terminals of an identified neuronal population is crucial. Howeve...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-15-8763-4_27

    authors: Chuhma N

    更新日期:2021-01-01 00:00:00

  • Bioluminescence-Optogenetics.

    abstract::In this chapter, we introduce a relatively new, emerging method for molecular neuromodulation-bioluminescence-optogenetics. Bioluminescence-optogenetics is mediated by luminopsin fusion proteins-light-sensing opsins fused to light-emitting luciferases. We describe their structures and working mechanisms and discuss th...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-15-8763-4_17

    authors: Berglund K,Stern MA,Gross RE

    更新日期:2021-01-01 00:00:00

  • Photoactivated Adenylyl Cyclases: Fundamental Properties and Applications.

    abstract::Photoactivated adenylyl cyclase (PAC) was first discovered to be a sensor for photoavoidance in the flagellate Euglena gracilis. PAC is a flavoprotein that catalyzes the production of cAMP upon illumination with blue light, which enables us to optogenetically manipulate intracellular cAMP levels in various biological ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-15-8763-4_7

    authors: Iseki M,Park SY

    更新日期:2021-01-01 00:00:00

  • Constituents of Cannabis Sativa.

    abstract::The Cannabis sativa plant has been used medicinally and recreationally for thousands of years, but recently only relatively some of its constituents have been identified. There are more than 550 chemical compounds in cannabis, with more than 100 phytocannabinoids being identified, including Δ9-tetrahydrocannabinol (TH...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-030-57369-0_1

    authors: Rock EM,Parker LA

    更新日期:2021-01-01 00:00:00

  • A Multi-omics Data Resource for Frontotemporal Dementia Research.

    abstract::Frontotemporal dementia (FTD) is a neurodegenerative disease with high heritability. Almost half of all familial cases are caused by mutations in one of the three genes MAPT, GRN and C9orf72. Even though major advances in FTD research have been achieved during the last decades, it is not yet fully understood how mutat...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-030-51140-1_16

    authors: Heutink P,Menden K,Dalmia A

    更新日期:2021-01-01 00:00:00

  • Roles of Slit Ligands and Their Roundabout (Robo) Family of Receptors in Bone Remodeling.

    abstract::Slit guidance ligands (Slits) and their roundabout (Robo) family of receptors are well-known axon guidance molecules that were originally identified in Drosophila mutants with commissural axon pathfinding defects. However, Slit-Robo signaling has been shown to be involved in not only neurogenesis, but also the develop...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2020_586

    authors: Niimi T

    更新日期:2020-09-29 00:00:00

  • Human Inhalation Study with Zinc Oxide: Analysis of Zinc Levels and Biomarkers in Exhaled Breath Condensate.

    abstract::Workers in the zinc processing, for example, welding or hot-dip galvanizing, are exposed to aerosols consisting of particles and gases, including zinc oxide (ZnO), which can affect human health. In this study, we addressed the effects of short-term controlled exposure to nano-sized ZnO on the airway inflammatory marke...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2020_572

    authors: Monsé C,Hagemeyer O,van Kampen V,Raulf M,Weiss T,Menne E,Jettkant B,Kendzia B,Merget R,Brüning T,Bünger J

    更新日期:2020-08-30 00:00:00

  • Evaluation of Microbial Growth in Hospital Textiles Through Challenge Test.

    abstract:INTRODUCTION:Ensuring the microbiological quality of textiles is an important requirement for health care facilities. The present study examines the way transport times and temperatures influence microbial growth in textiles. Therefore, the effectiveness of washing and disinfection processes has also been studied. MET...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2020_560

    authors: Carraro V,Sanna A,Pinna A,Carrucciu G,Succa S,Marras L,Bertolino G,Coroneo V

    更新日期:2020-06-29 00:00:00

  • The Good and Bad Sides of Heparanase-1 and Heparanase-2.

    abstract::In this chapter, we will emphasize the importance of heparan sulfate proteoglycans (HSPG) in controlling various physiological and pathological molecular mechanisms and discuss how the heparanase enzyme can modulate the effects triggered by HSPG. Additionally, we will also navigate about the existing knowledge of the ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-34521-1_36

    authors: Pinhal MAS,Melo CM,Nader HB

    更新日期:2020-01-01 00:00:00

  • Heparanase in Kidney Disease.

    abstract::The primary filtration of blood occurs in the glomerulus in the kidney. Destruction of any of the layers of the glomerular filtration barrier might result in proteinuric disease. The glomerular endothelial cells and especially its covering layer, the glycocalyx, play a pivotal role in development of albuminuria. One o...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-34521-1_26

    authors: van der Vlag J,Buijsers B

    更新日期:2020-01-01 00:00:00

  • Heparanase is Involved in Leukocyte Migration.

    abstract::Leukocyte migration is essential for exerting self-defense mechanisms. During the extravasation process, leukocytes transmigrate through the endothelial lining and the subendothelial basement membrane. Accumulating evidence supports the involvement of heparanase in this process. Altered cellular distribution resulting...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-34521-1_16

    authors: Higashi N,Irimura T,Nakajima M

    更新日期:2020-01-01 00:00:00

  • Molecular Aspects of Heparanase Interaction with Heparan Sulfate, Heparin and Glycol Split Heparin.

    abstract::Heparanase is the principal enzyme that degrades heparan sulfate (HS) in both physiological (HS turnover) and pathological (tumor metastasis, inflammation) cell conditions, catalysing the hydrolysis of the β-1-4 glycosidic bond in -GlcUA-β(1-4)-GlcNX-. Despite efforts to define the minimum trisaccharide sequence that ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-34521-1_6

    authors: Elli S,Guerrini M

    更新日期:2020-01-01 00:00:00

  • Iron in the Tumor Microenvironment.

    abstract::Cancer metabolism is a well-known target of cancer therapeutics. Classically, cancer metabolism has been studied in terms of the dependence of cancer cells on crucial metabolites, such as glucose and glutamine. But, the accumulating data show that iron metabolism in tumor microenvironment is also an important factor i...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-43093-1_3

    authors: Vela D

    更新日期:2020-01-01 00:00:00

  • Hormone Therapy in Menopause.

    abstract::As longevity expands, women are spending a third of their existence in menopause and beyond. The vast majority suffer from symptoms that negatively impact their quality of life. Systemic vasomotor symptoms (VMS) are the classic cluster affecting 80% of peri- and post-menopausal women. Once thought to be relatively bri...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-38474-6_6

    authors: Paciuc J

    更新日期:2020-01-01 00:00:00

  • Addressing Variability and Heterogeneity of Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

    abstract::Induced pluripotent stem cells (iPSCs) offer great promise in the areas of disease modeling, basic research, drug development, and regenerative medicine. Much of their value comes from the fact that they can be used to create otherwise inaccessible cell types, such as cardiomyocytes, which are genetically matched to a...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/5584_2019_350

    authors: Biendarra-Tiegs SM,Secreto FJ,Nelson TJ

    更新日期:2020-01-01 00:00:00

  • Neural Circuit Mechanisms That Underlie Parental Care.

    abstract::In mammals, parental care is essential for the survival of the young; therefore, it is vitally important to the propagation of the species. These behaviors, differing between the two sexes, are innate, stereotyped, and are also modified by an individual's reproductive experience. These characteristics suggest that neu...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-15-7086-5_6

    authors: Yu ZX,Li XY,Xu XH

    更新日期:2020-01-01 00:00:00

  • Fertility Counseling and Preservation for Breast Cancer Patients.

    abstract::Fertility preservation includes all the necessary steps that have to be taken in order to implement a woman's aim for preserving and enhancing her future chances of having her own biological offspring.There are two available choices for patients to maintain their fertility.The first category includes all the preventiv...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-41596-9_25

    authors: Dinas KD

    更新日期:2020-01-01 00:00:00

  • Systemic Treatments in Pregnancy-Associated Breast Cancer.

    abstract::Available data on systemic treatments in pregnancy-associated breast cancer (PABC) is reviewed in this section. These treatments include chemotherapy, endocrine therapy (ET), small molecule inhibitors, monoclonal antibodies against human epidermal growth factor receptor 2 (EGFR-2) also known as HER2; and human epiderm...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-41596-9_15

    authors: Tehrani OS

    更新日期:2020-01-01 00:00:00

  • Human Hair: Scaffold Materials for Regenerative Medicine.

    abstract::This chapter reviews the studies of keratin-based biomaterials in the past and discusses the advancement of it in recent years. Keratin, as a protein-based biopolymer, possesses excellent biocompatibility and biodegradability. In addition, keratin has abundant disulfide bonds, which result in its unique and tough stru...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-15-3258-0_14

    authors: Chen IC,Yu J

    更新日期:2020-01-01 00:00:00

  • Novel Polycationic Photosensitizers for Antibacterial Photodynamic Therapy.

    abstract::Antibacterial photodynamic therapy (APDT) is a promising method of treating local infected foci, in particular, surgical and burn wounds, trophic and diabetic ulcers. Photodynamic inactivation (PDI) is able to effectively destroy bacterial cells without them developing resistance in response to treatment.This work was...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/5584_2019_431

    authors: Meerovich GA,Akhlyustina EV,Tiganova IG,Lukyanets EA,Makarova EA,Tolordava ER,Yuzhakova OA,Romanishkin ID,Philipova NI,Zhizhimova YS,Romanova YM,Loschenov VB,Gintsburg AL

    更新日期:2020-01-01 00:00:00

  • Clinical Presentations of Breast Disorders in Pregnancy and Lactation.

    abstract::The breast tissue undergoes significant physiological change during pregnancy and lactation. These changes can give rise to some unique disorders during pregnancy , puerperium and lactation or exaggerate pre-existing conditions. Clinical examination becomes less reliable due to textural change and density of breast ti...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-41596-9_5

    authors: Kulkarni D

    更新日期:2020-01-01 00:00:00

  • Silk Fibroin Bioinks for Digital Light Processing (DLP) 3D Bioprinting.

    abstract::Three-dimensional (3D) bioprinting has been a highly influential technology in the field of tissue engineering to enable speedy and precise spatial patterning of cells, growth factors, and biomaterials. Bioink is one of the main factors in 3D bioprinting, and hydrogels are excellent matrix type by means of bioinks for...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-15-3258-0_4

    authors: Kim SH,Kim DY,Lim TH,Park CH

    更新日期:2020-01-01 00:00:00

  • The Development of Extracellular Vesicle-Integrated Biomaterials for Bone Regeneration.

    abstract::The clinical need for effective bone regeneration remains in huge demands. Although autologous and allogeneic bone grafts are generally considered "gold standard" treatments for bone defects, these approaches may result in various complications. Furthermore, safety considerations of gene- and cell-based therapies requ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-15-3262-7_7

    authors: Zhou Y,Xiao Y

    更新日期:2020-01-01 00:00:00

  • Stem Cell Culture Under Simulated Microgravity.

    abstract::Challenging environment of space causes several pivotal alterations in living systems, especially due to microgravity. The possibility of simulating microgravity by ground-based systems provides research opportunities that may lead to the understanding of in vitro biological effects of microgravity by eliminating the ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2020_539

    authors: Anil-Inevi M,Sarigil O,Kizilkaya M,Mese G,Tekin HC,Ozcivici E

    更新日期:2020-01-01 00:00:00

  • Comprehensive Geriatric Assessment in Cardiovascular Disease.

    abstract::Frailty and cardiovascular disease (CVD) are both highly prevalent in older adults. Cardiovascular disease has been identified as the most frequent cause of death, while frailty has been identified as one of geriatric giants characterized by decreased physiological reserves and increased vulnerability. However, the ex...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-33330-0_10

    authors: Demurtas J,Ecarnot F,Cernesi S,Solari M,Munoz MA,Cella A

    更新日期:2020-01-01 00:00:00

  • Time-Resolved NIROT 'Pioneer' System for Imaging Oxygenation of the Preterm Brain: Preliminary Results.

    abstract::In preterm infants, there is a risk of long-term cognitive, motor and behavioral impairments due to hemorrhagic and/or ischemic lesions. If detected early, lesions can be prevented. A bedside imaging modality, capable of early detection of both disorders, is necessary. We present the state of development of a tomograp...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-030-34461-0_44

    authors: Di Costanzo-Mata A,Jiang J,Lindner S,Ahnen L,Zhang C,Sánchez-Majos S,Wolf M,Charbon E,Kalyanov A

    更新日期:2020-01-01 00:00:00

  • Role of Microtubule-Associated Factors in HIF1α Nuclear Translocation.

    abstract::Adaptation to hypoxia is essential for regulating the survival and functions of hypoxic cells; it is mainly mediated by the hypoxia-inducible factor 1 (HIF1). The alpha subunit of HIF1 (HIF1α) is a well-known regulatory component of HIF1, which is tightly controlled by various types of HIF1α-regulating processes. Prev...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-34461-0_34

    authors: Lee HJ,Han HJ

    更新日期:2020-01-01 00:00:00

  • Effect of Exercise Duration on Post-Exercise Persistence of Oxyhemoglobin Changes in the Premotor Cortex: A Near-Infrared Spectroscopy Study in Moderate-Intensity Cycling Exercise.

    abstract::Measurement of oxyhemoglobin (O2Hb) changes in the cerebral cortex using near-infrared spectroscopy (NIRS) shows that its levels increase during moderate-intensity exercise and persists after exercise. However, the effects of exercise duration on O2Hb persistence in the premotor cortex (PMC) are unknown. We aimed to d...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-030-34461-0_24

    authors: Tsubaki A,Morishita S,Tokunaga Y,Sato D,Qin W,Kojima S,Onishi H

    更新日期:2020-01-01 00:00:00

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