Abstract：
:To develop an osteochondral tissue regeneration strategy it is extremely important to take into account the multiscale organization of the natural extracellular matrix. The structure and gradients of organic and inorganic components present in the cartilage and bone tissues must be considered together. Another critical aspect is an efficient interface between both tissues. So far, most of the approaches were focused on the development of multilayer or stratified scaffolds which resemble the structural composition of bone and cartilage, not considering in detail a transitional interface layer. Typically, those scaffolds have been produced by the combined use of two or more processing techniques (microtechnologies and nanotechnologies) and materials (organic and inorganic). A significant number of works was focused on either cartilage or bone, but there is a growing interest in the development of the osteochondral interface and in tissue engineering models of composite constructs that can mimic the cartilage/bone tissues. The few works that give attention to the interface between cartilage and bone, as well as to the biochemical gradients observed at the osteochondral unit, are also herein described.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Martins A,Reis RL,Neves NMdoi
10.1007/978-3-319-76711-6_6subject
Has Abstractpub_date
2018-01-01 00:00:00pages
125-139eissn
0065-2598issn
2214-8019journal_volume
1058pub_type
杂志文章,评审abstract：:Lead (Pb2+) is a developmental neurotoxicant that causes lifelong cognitive dysfunctions. In particular, Pb2+-induced frontoexecutive dysfunctions emerge later in life when the cortex is fully myelinated, thereby permitting the ability to assess the extent to which Pb2+ has developmentally impacted higher order cognit...
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4899-2444-5_17
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journal_title：Advances in experimental medicine and biology
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更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/978-1-4684-5979-1_11
更新日期：1991-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Advances in experimental medicine and biology
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doi：
更新日期：1988-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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journal_title：Advances in experimental medicine and biology
pub_type： 临床试验,杂志文章
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/5584_2017_48
更新日期：2018-01-01 00:00:00
