Abstract：
:Notch signaling exerts multiple important functions in the hematopoietic system. Notch1-mediated signals are essential to induce the onset of definitive hematopoiesis within specialized domains of hemogenic endothelium in the fetal dorsal aorta. In contrast, Notch is dispensable for the subsequent maintenance of hematopoietic stem cells in the adult bone marrow. Notch is a key regulator of early T-cell development in the thymus. An expanding number of hematopoietic and lymphoid cell types have been reported to receive context-dependent inputs from the Notch pathway that regulate their differentiation and function. Progress in the field will continue to bring fundamental information about hematopoiesis and practical insights into the potential to modulate Notch signaling for therapeutic purposes.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Sandy AR,Jones M,Maillard Idoi
10.1007/978-1-4614-0899-4_6subject
Has Abstractpub_date
2012-01-01 00:00:00pages
71-88eissn
0065-2598issn
2214-8019journal_volume
727pub_type
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