Abstract:
:Cyclic variations in calcium (Ca(2+)) concentrations, through a process called excitation-contraction coupling, allow regulation of vascular smooth muscle cells contractility and thus modulation of vascular tone and blood pressure. As a second messenger, Ca(2+) also activates signaling cascades leading to transcription factors activation in a process called excitation-transcription coupling. Furthermore, recent evidences indicate an interaction between post-transcriptional regulation by microRNAs (miRNAs) and Ca(2+) signaling. All these actors, which are frequently altered in vascular diseases, will be reviewed here.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Marchand A,Abi-Gerges A,Saliba Y,Merlet E,Lompré AMdoi
10.1007/978-94-007-2888-2_35subject
Has Abstractpub_date
2012-01-01 00:00:00pages
795-810eissn
0065-2598issn
2214-8019journal_volume
740pub_type
杂志文章,评审abstract::The mammalian thioredoxins are a family of small redox proteins that undergo NADPH dependent reduction by thioredoxin reductase. Reduced thioredoxins reduce oxidized cysteine groups on proteins including transcription factors to increase their binding to DNA, and is a source of reducing equivalents for enzymes such as...
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4614-0631-0_103
更新日期:2012-01-01 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 临床试验,杂志文章
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abstract::We examined whether acetazolamide (ACZ), a carbonic anhydrase inhibitor, would alter post-hypoxic ventilatory behavior and periodic breathing in the C57BL/6J (B6) mouse. Experiments were performed with unanaesthetized, awake adult male B6 mice (n = 5, 2.5 months old, 21.3 +/- 1.5 g, mean +/- SD) and ventilatory behavi...
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
abstract::Our understanding of breast cancer and its therapeutic approach has improved greatly due to the advancement of molecular biology in recent years. Clinically, breast cancers are characterized into three basic types based on their immunohistochemical properties. They are triple-negative breast cancer, estrogen receptor ...
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pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
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更新日期:1998-01-01 00:00:00
abstract::This chapter explores the concepts, processes, tools and challenges relating to the validation of alternative methods for toxicity and safety testing. In general terms, validation is the process of assessing the appropriateness and usefulness of a tool for its intended purpose. Validation is routinely used in various ...
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更新日期:2016-01-01 00:00:00
abstract::Legume proteins are relatively deficient in the sulfur amino acids. Among the different strategies to increase the sulfur amino acid contents of legumes, we have chosen to increase the biosynthesis of endogenous, non-abundant sulfur-rich proteins we have identified in soybean seed. We identified and isolated an 8 kDa ...
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doi:10.1007/978-1-4615-0713-0_57
更新日期:2002-01-01 00:00:00
abstract::Doxorubicin is an anthracycline and one of the more effective chemotherapy agents used in the treatment of children, adolescents, and adults with osteosarcoma. Despite its effectiveness, cardiotoxicity is a major late effect that compromises the survival and quality of life of survivors of this and other cancers. Card...
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pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
abstract::In order to determine the degree of mechanochemical coupling in actomyosin in vitro motility assays, it is desirable to measure the sliding velocity and the associated ATP turnover simultaneously at the single filament level. Actin sliding over tracks of immobilised heavy meromyosin (HMM) has been initiated by flash p...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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abstract::Young chicks were experimentally infected with 6 strains of AEEC isolated from calves, pigs, chicks, and humans. AEEC colonized the cecum of chicks and induced the AE lesions on the mucosal surface. In the early stages of the AE lesions, AEEC attached to the enterocyte were enfolded with the microvilli. In the advance...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4899-1828-4_16
更新日期:1997-01-01 00:00:00
abstract::As the main catalytic and structural molecules within living systems, proteins are the most likely biomolecules to be affected by radiation exposure. Proteomics, the comprehensive characterization of proteins within complex biological samples, is therefore a research approach ideally suited to assess the effects of ra...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00