Abstract：
:Adipose-Derived Stromal/Stem Cells (ASC) have considerable potential for regenerative medicine due to their abilities to proliferate, differentiate into multiple cell lineages, high cell yield, relative ease of acquisition, and almost no ethical concerns since they are derived from adult tissue. Storage of ASC by cryopreservation has been well described that maintains high cell yield and viability, stable immunophenotype, and robust differentiation potential post-thaw. This ability is crucial for banking research and for clinical therapeutic purposes that avoid the morbidity related to repetitive liposuction tissue harvests. ASC secrete various biomolecules such as cytokines which are reported to have immunomodulatory properties and therapeutic potential to reverse symptoms of multiple degenerative diseases/disorders. Nevertheless, safety regarding the use of these cells clinically is still under investigation. This chapter focuses on the different aspects of cryopreserved ASC and the methods to evaluate their functionality for future clinical use.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Zanata F,Shaik S,Devireddy RV,Wu X,Ferreira LM,Gimble JMdoi
10.1007/978-3-319-45457-3_11subject
Has Abstractpub_date
2016-01-01 00:00:00pages
137-146eissn
0065-2598issn
2214-8019journal_volume
951pub_type
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journal_title：Advances in experimental medicine and biology
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