Abstract：
:To obtain proteins with the complement-depleting activity of Cobra Venom Factor (CVF), but with less immunogenicity, we have prepared human C3/CVF hybrid proteins, in which the C-terminus of the alpha-chain of human C3 is exchanged with homologous regions of the C-terminus of the beta-chain of CVF. We show that these hybrid proteins are able to deplete complement, both in vitro and in vivo. One hybrid protein, HC3-1496, is shown to be effective in reducing complement-mediated damage in two disease models in mice, collagen-induced arthritis and myocardial ischemia/reperfusion injury. Human C3/CVF hybrid proteins represent a novel class ofbiologicals as potential therapeutic agents in many diseases where complement is involved in the pathogenesis.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Fritzinger DC,Hew BE,Lee JQ,Newhouse J,Alam M,Ciallella JR,Bowers M,Gorsuch WB,Guikema BJ,Stahl GL,Vogel CWsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
293-307eissn
0065-2598issn
2214-8019journal_volume
632pub_type
杂志文章,评审abstract：:Near infrared spectroscopy (NIRS) may provide valuable insight into the determinants of exercise performance. We examined the effects of severe hypoxia on cerebral (prefrontal lobe) and muscle (gastrocnemius) oxygenation at rest and during a fatiguing task. After a 15-min rest, 15 healthy subjects (age 25.3 +/- 0.9 yr...
journal_title：Advances in experimental medicine and biology
pub_type： 临床试验,杂志文章
doi：10.1007/978-0-387-85998-9_49
更新日期：2009-01-01 00:00:00
abstract：:The Cannabis sativa plant has been used medicinally and recreationally for thousands of years, but recently only relatively some of its constituents have been identified. There are more than 550 chemical compounds in cannabis, with more than 100 phytocannabinoids being identified, including Δ9-tetrahydrocannabinol (TH...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-030-57369-0_1
更新日期：2021-01-01 00:00:00
abstract：:Fungi that tolerate very high environmental NaCl concentrations are good model systems to study mechanisms that enable them to endure osmotic and salinity stress. The whole genome sequences of six such fungal species have been analysed: Hortaea werneckii, Wallemia ichthyophaga and four Aureobasidium spp.: A. pullulans...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-25304-6_13
更新日期：2016-01-01 00:00:00
abstract：:Major congenital anomalies are detectable in 2-3 % of the newborn population. Some of their genetic causes are attributable to copy number variations identified by array comparative genomic hybridization (aCGH). The value of aCGH screening as a first-tier test in children with multiple congenital anomalies has been st...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/5584_2016_235
更新日期：2016-01-01 00:00:00
abstract：:Intramolecular ADP-ribose transfer reactions result in the formation of cyclic ADP-ribose (cADPR) and 2'-phospho-cyclic ADP-ribose (P-cADPR) from NAD and NADP, respectively. The potent Ca2+ releasing activity of these cyclic nucleotides has led to the postulation that they function as second messengers of Ca2+ signall...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:In this chapter, we will review studies of HER2 in osteosarcoma and discuss the controversies that have existed in this field. Our present understanding of HER2 in the context of osteosarcoma is that it is expressed on a subset of patient samples, but that expression is not prognostic. We will review the two trials th...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-43032-0_5
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abstract：:The intramural blood vessels and fluid-filled interstitial space form a hydraulic continuum enmeshed by myocardial muscle layers and collagen matrix. Coronary circulation was found to be strongly influenced by passive and active properties of the muscle surrounding the coronary microvasculature. Selective remodeling o...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-2946-0_11
更新日期：1993-01-01 00:00:00
abstract：:Cellular organization through cytoskeletal trafficking is a process of fundamental importance. Highly specialized systems evolved that enable motors to identify and select the optimal tracks for motility. In this chapter, we examine the profound effect of actin filament networks on myosin motility patterns. We argue t...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-38062-5_9
更新日期：2020-01-01 00:00:00
abstract：:Taurine modulates renal and cardiovascular function. Although the kidney regulates body taurine status, the impact of renal and cardiovascular risk factors, such as dietary intake of excess NaCl and saturated fat, on renal handling of taurine is less clear. One would predict that the kidney would modulate taurine excr...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-0-387-33504-9_17
更新日期：2006-01-01 00:00:00
abstract：:Ceramides are bioactive sphingolipids that support the structure of the plasma membrane and mediate numerous cell-signaling events in eukaryotic cells. The finding that ceramides act as second messengers transducing cellular signals has attracted substantial attention in several fields of Biology. Since all cells cont...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-21735-8_15
更新日期：2019-01-01 00:00:00
abstract：:The present study aims at delineating residues in the vasopressin/oxytocin receptor family responsible for the high affinity binding of the hormone. Therefore, we have constructed a computer-generated 3 dimensional model of the rat V1a vasopressin receptor subtype which allowed us to propose residues likely to be invo...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:A new approach to measure muscle oxygen saturation (SmO(2)) using near infrared spectroscopy (NIRS) has been proposed in this paper. This approach exploits the cyclic NIRS signals seen during exercise which are often regarded as "movement artefacts". This new measure, which we term the "cyclic SmO(2)", has the potenti...
journal_title：Advances in experimental medicine and biology
pub_type： 临床试验,杂志文章
doi：10.1007/978-1-4419-1241-1_26
更新日期：2010-01-01 00:00:00
abstract：:We performed a detailed and comprehensive study of the involvement of tumor suppressor genes in human prostate cancer. We utilized primers flanking either the restriction fragment length polymorphism (RFLP) or variable number of tandem repeat [VNTR; microsatellite or simple repeat site (SRS)] polymorphic sites to poly...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4899-1813-0_7
更新日期：1997-01-01 00:00:00
abstract：:Ca(2+) entry pathways play important roles in control of many cellular functions, including long-term proliferation, migration and cell death. In recent years, it is becoming increasingly clear that, in some types of tumors, remodeling of Ca(2+) entry pathways could contribute to cancer hallmarks such as excessive pro...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-26974-0_19
更新日期：2016-01-01 00:00:00
abstract：:Cross-bridge structure and mechanics were studied during development of skinned frog muscle fiber contractions initiated by photolysis of DM-nitrophen (a caged Ca2+). Stiffness rises earlier than tension following photo-release of Ca2+. A similar lead of stiffness in electrically stimulated fibers and the early rise o...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4615-2872-2_43
更新日期：1993-01-01 00:00:00
abstract：:The relationship between oxygen concentrations in arteries, cytosol, and mitochondria and high energy phosphate metabolism was studied in perfused rat hearts subjected to low and high workloads during gradual hypoxia. PCr, ATP, and Pi were measured by 31P-NMR. Myoglobin oxygenation and cytochrome aa3 oxidation were me...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-8181-5_50
更新日期：1990-01-01 00:00:00
abstract：:The primary goal of this project was to elucidate the spatial pattern of capillaries in three hamster striated muscles according to statistical techniques of pattern analysis. The spatial pattern of capillaries and traditional measures of capillarity are important to understanding the supply and distribution of oxygen...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-5643-1_30
更新日期：1989-01-01 00:00:00
abstract：:Excessive oxidation and antioxidant imbalance resulting from several conditions may cause sperm DNA damage, which, in turn, affect male fertility, both natural and assisted. Sperm DNA damage transferred to the embryo might also affect the health of offspring. Several conditions associated with excessive oxidative stre...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-030-21664-1_8
更新日期：2019-01-01 00:00:00
abstract：:The eye is an excellent target organ for gene therapy. It is physically isolated, easily accessible, immune-privileged, and postmitotic. Furthermore, potential gene therapies introduced into the eye can be evaluated by noninvasive methods such as fundoscopy, electroretinography, and optical coherence tomography. In th...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-27378-1_11
更新日期：2019-01-01 00:00:00
abstract：:Chromosome 22q11.2 deletion (CH22qD) syndrome is also known as DiGeorge syndrome or velocardiofacial syndrome. This deletion syndrome is extremely common with nearly one in 4000 children being affected. Recent advances and a holistic approach to patients have improved the care and well-being of these patients. This re...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-0-387-72005-0_4
更新日期：2007-01-01 00:00:00
abstract：:Accumulating evidence has demonstrated that exercise training not only reduces cardiovascular disease risk but also provides direct endogenous cardiovascular protection. The mechanisms that have been proposed to be responsible for exercise-induced cardioprotection include intrinsic myocardial changes such as increased...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-15-1792-1_14
更新日期：2020-01-01 00:00:00
abstract：:T cell clones are useful models for studying lymphocyte function both at the level of the individual cell and in interacting systems. Murine cytolytic and non- cytolyic T cell clones have been obtained with relative ease, and the particular procedure used to derive and maintain T cell clones may influence profoundly t...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-9376-8_20
更新日期：1984-01-01 00:00:00
abstract：:There is no doubt that feeding and nutrient availability modify the metabolism through hormonal changes. It is otherwise interesting to better define the influence of the imposed or freely chosen meal distribution during the day; in fact the daily feed intake in a relatively short time, namely during the daylight, see...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/0-306-46832-8_27
更新日期：2000-01-01 00:00:00
abstract：:In summary, despite the many uncertainties regarding mode of action, these results have established that the soluble dietary fibre from oats, mainly (1----3)(1----4)-beta-D-glucan, is physiologically active in a fashion similar to guar gum. Extraction processes reduce the molecular size of the beta-glucan relative to ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4684-5784-1_11
更新日期：1990-01-01 00:00:00
abstract：:Zebrafish embryos can be obtained for research purposes in large numbers at low cost and embryos develop externally in limited space, making them highly suitable for high-throughput cancer studies and drug screens. Non-invasive live imaging of various processes within the larvae is possible due to their transparency d...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-30654-4_14
更新日期：2016-01-01 00:00:00
abstract：:Taurine (2-aminoethanesulfonic acid) is a sulfur-containing organic acid, which has various physiological functions, including membrane stabilization, cell-volume regulation, mitochondrial protein translocation, anti-oxidative activity, neuroprotection against neurotoxicity and modulation of intracellular calcium leve...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-94-024-1079-2_2
更新日期：2017-01-01 00:00:00
abstract：:Virtual imaging, image manipulation and morphometric methods are increasingly used in medicine and the natural sciences. Virtual imaging hardware and image manipulation software allows us to readily visualise, explore, alter, repair and study digital objects. This suite of equipment and tools combined with statistical...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-24281-7_6
更新日期：2019-01-01 00:00:00
abstract：:Enteropathogenic Escherichia coli (EPEC) produce attaching and effacing lesions. The genes responsible for this lesion are clustered on the chromosome forming a 35.5 kilobase pathogenesis island called LEE. The LEE was identified, characterized and completely sequenced from the human EPEC strain E2348/69. The LEE carr...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-4143-1_11
更新日期：1999-01-01 00:00:00
abstract：UNLABELLED:Premature infants require large amounts of protein and energy to achieve normal growth. Feeding with human milk alone is therefore only regarded acceptable if the protein and energy content is adequate. METHODS:476 milk samples from 101 mothers delivering before the 32nd gestational week (mean gestational a...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-1371-1_51
更新日期：2001-01-01 00:00:00
abstract：:The majority of the human genome is found to be transcribed and generates mostly noncoding (nc) RNAs that do not possess protein information. MicroRNAs are one of the well-identified small ncRNAs, but occupy merely a fraction of ncRNAs. Long (large) ncRNAs are emerging as a novel class of ncRNAs, but knowledge of thes...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4614-0332-6_12
更新日期：2011-01-01 00:00:00
