Abstract：
:In preterm infants, there is a risk of long-term cognitive, motor and behavioral impairments due to hemorrhagic and/or ischemic lesions. If detected early, lesions can be prevented. A bedside imaging modality, capable of early detection of both disorders, is necessary. We present the state of development of a tomographic imager (named Pioneer), that will be capable of determining the oxygenation of the preterm-infant brain with high spatial resolution. Pioneer is a time-resolved near-infrared optical tomography (TR NIROT) instrument. It employs multiple wavelength laser light in short pulses on 11 distinct locations and measures the re-emerging light in a contactless fashion by means of a time-correlated single-photon counting (TCSPC) camera (named Piccolo) covering ~4.9 cm2 with 300 detectors. Timing response of the entire system is 116 ps. An in-house designed biocompatible source ring ensures fixed relative positions of sources and detectors and provides a secure interface between the patient and the probe. At the present state, the NIROT Pioneer system successfully detected a 6x6x50 mm3 inclusion 3 cm deep inside a phantom. These results confirm that the Pioneer imager is working as expected and is on a solid path towards full 3D tissue oxygenation imaging.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Di Costanzo-Mata A,Jiang J,Lindner S,Ahnen L,Zhang C,Sánchez-Majos S,Wolf M,Charbon E,Kalyanov Adoi
10.1007/978-3-030-34461-0_44subject
Has Abstractpub_date
2020-01-01 00:00:00pages
347-354eissn
0065-2598issn
2214-8019journal_volume
1232pub_type
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