Abstract：
:Brain lateralization is a ubiquitous feature of neural organization across the vertebrate spectrum. We have developed a model of motor lateralization that attributes different motor control processes to each cerebral hemisphere. This bilateral hemispheric model of motor control has successfully predicted hemisphere-specific motor control and motor learning deficits in the ipsilesional, or non-paretic, arm of patients with unilateral stroke. We now show across large number and range of stroke patients that these motor performance deficits in the non-paretic arm of stroke patients vary with both the side of the lesion, as well as with the severity of contralesional impairment. This last point can be functionally devastating for patients with severe contralesional paresis because for these individuals, performance of upper extremity activities of daily living depends primarily and often exclusively on ipsilesional arm function. We present a pilot study focused on improving the speed and coordination of ipsilesional arm function in a convenience sample of three stroke patients with severe contralesional impairment. Over a three-week period, patients received a total of nine 1.5 h sessions of training that included intense practice of virtual reality and real-life tasks. Our results indicated substantial improvements in ipsilesional arm movement kinematics, functional performance, and that these improvements carried over to improve functional independence. In addition, the contralesional arm improved in our measure of contralesional impairment, which was likely due to improved participation in activities of daily living. We discuss of our findings for physical rehabilitation.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Sainburg RL,Maenza C,Winstein C,Good Ddoi
10.1007/978-3-319-47313-0_14subject
Has Abstractpub_date
2016-01-01 00:00:00pages
257-272eissn
0065-2598issn
2214-8019journal_volume
957pub_type
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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journal_title：Advances in experimental medicine and biology
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更新日期：2017-01-01 00:00:00
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更新日期：2016-01-01 00:00:00
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doi：10.1007/978-1-4419-1399-9_25
更新日期：2010-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-90-481-3271-3_20
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-1-4757-0731-1_12
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-0-387-72124-8_31
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
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abstract：:The effects of IABP on the contractile state of the in situ canine heart was evaluated under control conditions and conditions of regional ischemia by determining the transient slope of the end-systolic pressure-volume line, T-Emax. For comparison, the conventional index reflecting contractility, dP/dtmax and other re...
journal_title：Advances in experimental medicine and biology
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更新日期：1989-01-01 00:00:00
abstract：:In normal and cancer cells, successful cell division requires accurate duplication of chromosomal DNA. All cells require a multiprotein DNA duplication system (replisomes) for their existence. However, death of normal cells in our body occurs through the apoptotic process. During apoptotic process several crucial gene...
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journal_title：Advances in experimental medicine and biology
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更新日期：1979-01-01 00:00:00
