Abstract：
:Lipid composition and Ca2+ transport properties were examined in the isolated sarcoplasmic reticulum of non-exercised muscles of markedly phosphorus depleted rats. Phosphorous depletion with a fall of plasma Pi from 8.04 +/- 0.85 to 2.56 +/- 0.48 mg/dl was accompanied by a decrease in muscle Pi and ATP content and by a significant decrease in the phospholipid/protein ratio of sarcoplasmic reticulum. The phosphatidyl -choline/phosphatidyl-ethanolamine ration in sarcoplasmic membranes was increased. Storing capacity for Ca2+ was significantly diminished. In contrast, there was no significant change of kinetic parameters of Ca2+ transport, i.e. of the initial rate of uptake and concentrating ability. These findings do not necessarily exclude changes of cytosolic Ca2+ concentration in phosphate depletion, but they exclude alterations of intrinsic kinetic properties of the sarcoplasmic reticulum as a cause of any such potential changes.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Kreusser W,Ritz E,Boland R,Brachmann Jdoi
10.1007/978-1-4615-9167-2_36subject
Has Abstractpub_date
1980-01-01 00:00:00pages
313-21eissn
0065-2598issn
2214-8019journal_volume
128pub_type
杂志文章abstract：:Neurodegeneration with brain iron accumulation (NBIA) is a group of seriously devastating and life-threatening rare monogenic diseases characterized by focal iron accumulation in the brain. The main symptoms of NBIA comprise progressive movement disorder, often including painful dystonia, parkinsonism, mental disabili...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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abstract：:Because homeobox-containing genes play a major role in embryogenesis and tissue identity in Drosophila and because similar genes encode tissue-specific transcription factors in mammalian cells, we hypothesized that homeobox genes might plan a role in hematopoietic differentiation and lineage commitment. We therefore s...
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abstract：:Although prevalence estimates are imprecise, growing numbers of women in the United States are living longer with metastatic breast cancer, attributable at least in part to the availability of effective targeted therapies. Women living with metastatic disease are understudied, however, and substantial heterogeneity ex...
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doi：10.1007/978-3-319-16366-6_16
更新日期：2015-01-01 00:00:00
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abstract：:In order to obtain evidence that Mb releases O(2) during muscle contraction, we have set up a buffer-perfused hindlimb rat model and applied NIRS to detect the dynamics of tissue deoxygenation during contraction. The NIRS signal was monitored on hindlimb muscle during twitch contractions at 1 Hz, evoked via electrosti...
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更新日期：2010-01-01 00:00:00
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更新日期：1982-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/978-981-13-1370-7_5
更新日期：2018-01-01 00:00:00
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更新日期：2019-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-01-01 00:00:00
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更新日期：2018-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-981-13-6657-4_12
更新日期：2019-01-01 00:00:00
abstract：:Oral drug administration is the most favorable route of drug administration in the clinic. Intestinal transporters have been shown to play a significant role in the rate and extent of drug absorption of some, but not all, drug molecules. Due to the heterogeneous expression of multiple transporters along the intestine,...
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doi：10.1007/978-981-13-7647-4_8
更新日期：2019-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-1-4615-2872-2_52
更新日期：1993-01-01 00:00:00
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更新日期：2018-01-01 00:00:00
abstract：:Electroencephalography (EEG) studies in Alzheimer's Disease (AD) patients show an attenuation of average power within the alpha band (7.5-13 Hz) and an increase of power in the theta band (4-7 Hz). Significant body of evidence suggest that thalamocortical circuitry underpin the generation and modulation of alpha and t...
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journal_title：Advances in experimental medicine and biology
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abstract：:Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the imm...
journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-981-13-3065-0_15
更新日期：2018-01-01 00:00:00
abstract：:The central function of renal glomeruli is plasma ultrafiltration for primary urine production. The glomerular filtration barrier consists of a fenestrated endothelium, the glomerular basement membrane and podocytes, mesenchymal-like cells with actin filament-rich protrusions, the "foot processes." Their architecture ...
journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-4-431-56550-5_20
更新日期：2017-01-01 00:00:00
abstract：:Multiple myeloma is a hematological malignancy. It is characterized by the abnormal clonal proliferation of malignant plasma cells in the bone marrow and the secretion of a large number of monoclonal immunoglobulins or light chains, causing bone destruction, elevated blood calcium levels, anemia, and renal dysfunction...
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更新日期：2020-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：2000-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：1978-01-01 00:00:00
abstract：:Gut microbiota are known to impact multiple organs including the lung. The cross talk between gut microbes and lungs, termed as the "gut-lung axis," is vital for immune response and homeostasis in the airways. In this chapter, we summarized the coordinated development of microorganisms in the gut and lung, exogenous a...
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更新日期：2020-01-01 00:00:00
abstract：:Fructose malabsorption is characterized by the inability to absorb fructose efficiently. Consequently fructose reaches the colon and is broken down by bacteria to short-fatty-acids, CO2 and H2. Recently we found that fructose malabsorption was associated with signs of depression. It was therefore of interest to find o...
journal_title：Advances in experimental medicine and biology
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更新日期：1999-01-01 00:00:00
abstract：:Properly performed, biomarker discovery can lead to effective candidates that can ultimately serve as predictors of disease, medical condition, define therapeutic parameters, and many other applications in medicine. Preferably, biomarkers comprise a panel of indicators, e.g. proteins and/or peptides that can be predic...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-41448-5_21
更新日期：2016-01-01 00:00:00
abstract：:To develop an osteochondral tissue regeneration strategy it is extremely important to take into account the multiscale organization of the natural extracellular matrix. The structure and gradients of organic and inorganic components present in the cartilage and bone tissues must be considered together. Another critica...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-76711-6_6
更新日期：2018-01-01 00:00:00
abstract：:Fertility preservation includes all the necessary steps that have to be taken in order to implement a woman's aim for preserving and enhancing her future chances of having her own biological offspring.There are two available choices for patients to maintain their fertility.The first category includes all the preventiv...
journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-3-030-41596-9_25
更新日期：2020-01-01 00:00:00
