Abstract:
:Cancer metabolism is a well-known target of cancer therapeutics. Classically, cancer metabolism has been studied in terms of the dependence of cancer cells on crucial metabolites, such as glucose and glutamine. But, the accumulating data show that iron metabolism in tumor microenvironment is also an important factor in preserving the survival of cancer cells. Cancer cells have a distinct phenotype of iron metabolism, which secures the much-needed iron for these metabolically active cells. In order to use this iron efficiently, cancer cells need to increase their iron supply and decrease iron loss. As recent research suggests, this is not only done by modifying the expression of iron-related proteins in cancer cells, but also by interaction of cancer cells with other cells from the tumor milieu. Tumor microenvironment is a dynamic environment characterized with intricate relationship between cancer cells, tumor-associated macrophages, fibroblasts, and other cells. Some of the mechanistic aspects of this relationship have been elucidated, while others are yet to be identified. In any case, identifying the details of the iron phenotype of the cells in tumor microenvironment presents with a new therapeutic opportunity to treat this deadly disease.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Vela Ddoi
10.1007/978-3-030-43093-1_3subject
Has Abstractpub_date
2020-01-01 00:00:00pages
39-51eissn
0065-2598issn
2214-8019journal_volume
1259pub_type
杂志文章,评审abstract::For the select fortunate recipients of organ transplants, transplantation affords the rare opportunity for a new life. Given the scarcity of organs for transplantation, it is imperative that the health of transplant recipients be optimized in order to fully benefit from this gift of life. Unfortunately, hypertension i...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/5584_2016_87
更新日期:2017-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4757-0145-6_12
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journal_title:Advances in experimental medicine and biology
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abstract::The characteristic functions of relaxin are associated with female reproductive tract physiology. These include the regulation of biochemical processes involved in remodeling the extracellular matrix of the cervix and vagina during pregnancy and rupture of the fetal membranes at term. Such modifications enable the you...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.1007/978-3-319-98788-0_14
更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-981-13-1396-7_23
更新日期:2018-01-01 00:00:00
abstract::Cytochrome P-450 has been purified from liver microsomes of phenobarbital-induced rabbits in the presence of ionic and nonionic detergents to concentrations over 17 nmoles per mg of protein. The purified cytochrome P-450 LM gives a single major band on SDS-polyacrylamide gel electrophoresis representing about 90 per c...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-9026-2_2
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4419-1241-1_36
更新日期:2010-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4615-0193-0_35
更新日期:2002-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-9140-5_8
更新日期:1980-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-77932-4_27
更新日期:2018-01-01 00:00:00
abstract::So far, more than 20 species of Ganoderma (Lingzhi) fungi have been studied, including G. lucidum, G. sinense, G. japonicum, G. capense, G. australe, G. tsugae, G. applanatum, G. tropicus, G. boniense, G. duropora, G. resinaceum, G. theaecolum, G. cochlear, G. atrum, G. formosanum, G. boninense, G. colossum, G. concin...
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abstract::Hypoxic ischemic encephalopathy (HIE) leads to significant mortality and morbidity, and therapeutic hypothermia (TH) has become a standard of care following HIE. After TH, the body temperature is brought back to 37 °C. Early electroencephalography (EEG) is a reliable outcome biomarker following HIE. We hypothesized th...
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pub_type: 杂志文章,评审
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4615-1885-3_31
更新日期:1995-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
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更新日期:2003-01-01 00:00:00
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更新日期:2020-01-01 00:00:00
abstract::Women lose bone during lactation, and this is an important mechanism to provide calcium for human milk. Bone loss during lactation occurs even in women with high calcium intakes. Lactation-induced bone loss is transient because bone density increases rapidly after weaning. Bone loss during lactation and recovery after...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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abstract::Patients with chronic obstructive pulmonary disease (COPD) have the lower airways colonized with pathogenic bacteria in a stable period of the disease and during exacerbations. The etiology of bacterial exacerbations of COPD depends on the underlying disease, the frequency of exacerbations and antibiotic therapy. Micr...
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更新日期:2015-01-01 00:00:00
abstract::Oxidative stress (OS) is common in inflammatory conditions and may be important in atopic dermatitis (AD) etiology. The aim of this project was to study the involvement of oxidation in FSL-1 (deacylated lipoprotein)-triggered signaling pathways leading to AD-typical cytokine expression in HaCaT keratinocytes. HaCaT ke...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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abstract::This work proposes to use a static Bayesian network as a tool to support medical decision in the on-line detection of Premature Ventricular Contraction beats (PVC) in electrocardiogram (ECG) records, which is a well known cardiac arrhythmia available for study in standard ECG databases. The main motivation to use Baye...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
abstract::The formation of the comutagenic tryptophan derivate norharman in heat-processed food is a well known phenomenon. As a first step to investigate the possible formation of norharman during food storage particularly in regard to fortified food we developed a model system and studied the non-enzymatic formation of the co...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-4709-9_89
更新日期:1999-01-01 00:00:00
abstract::AFM-based Single Molecule Force Spectroscopy provides a new tool for probing the mechanical properties of single molecules. In this chapter we show that the unfolding forces of single protein domains can be directly measured. Unfolding forces give new insight into protein stability that cannot be deduced from thermody...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00