Abstract：
:Chronic inflammatory diseases of the intestine (i.e. Crohn's and chronic ulcerative colitis- collectively known as inflammatory bowel disease [IBD]) are a very significant public health problem in the United States and other industrialized nations. Thus, effort has been made toward understanding the biological mechanisms that regulate such inflammation. Largely, these efforts have focused on identifying the mechanisms that mediate activation of inflammation and have succeeded in identifying a variety of signaling pathways by which a wide range of agonists can activate a mucosal immune inflammatory response. Playing a central role in many of these pathways is the intestinal epithelium, which serves as a barrier to, and interfaces with the outside world. However, recent studies have shown that not only can some agonists activate pro-inflammatory signals in intestinal epithelial cells, but other agonists can activate "anti-inflammatory" signals in these cells that dampen the responses to pro-inflammatory agonists. One such anti-inflammatory agonist is the eicosanoid lipoxin A4 (LXA4). Specifically, LXA4, its epimer 15-LXA4, and their analogs potently down-regulate defining and causative events of intestinal inflammation in an in vitro model. These compounds are now being tested for their ability to down-regulate inflammation in mouse models of colitis and may ultimately prove to be of significant benefit to individuals suffering from debilitating chronic inflammatory intestinal disorders.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Gewirtz AT,Neish AS,Madara JLdoi
10.1007/978-1-4615-0193-0_35subject
Has Abstractpub_date
2002-01-01 00:00:00pages
229-36eissn
0065-2598issn
2214-8019journal_volume
507pub_type
杂志文章,评审abstract：:The origin of some non communicable disease (NCDs) is in early life. Evidence has shown that early life nutrition is associated with the risk of developing chronic non communicable diseases. Pregnancy and infancy are the most critical stages that influence the risks of NCDs in childhood and adult life. Prenatal matern...
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更新日期：2016-01-01 00:00:00
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