Abstract:
:The most commonly used methods to study the mechanisms of hypocholesterolemic action of therapeutic agents generally determine the turnover of total (exchangeable) cholesterol pools in the body. This approach is based on the view that whatever increases the total load of cholesterol in the body will increase the levels of plasma cholesterol, and vice versa. Despite the importance of this assumption it has never been tested, and there is no evidence to indicate that it is valid under all conditions. This "overload" hypothesis dates from the times before the importance of plasma lipoproteins was recognized and their role in the transport of lipids was well understood. However, it is becoming increasingly clear that the levels of plasma cholesterol are determined more directly by the "transport" of cholesterol into and out of plasma compartment by lipoproteins than by the synthesis, absorption and elimination of cholesterol from the total body pools. Any effects that the latter parameters of cholesterol metabolism have on the levels of plasma cholesterol must be mediated through changes in synthesis and the subsequent metabolism of plasma lipoproteins. In other words, in any equation relating changes in the levels of plasma cholesterol to the changes in synthesis, absorption and elimination of cholesterol from the body pools we must consider the "transport" of cholesterol by lipoproteins and their metabolism.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Sodhi HS,Kudchodkar BJ,Clifford C,Borhani N,Mason DTdoi
10.1007/978-1-4684-0967-3_19subject
Has Abstractpub_date
1978-01-01 00:00:00pages
331-45eissn
0065-2598issn
2214-8019journal_volume
109pub_type
杂志文章,评审abstract::To clarify the mechanisms of power enhancement during counter-movement exercise, in vivo muscle fibre behavior during plantar flexion exercise was estimated by real time ultrasonography. Six healthy male subjects were requested to perform ankle plantar flexion exercise with counter-movement (CM, plantar flexion preced...
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abstract::This book highlights contributions from leaders in the field of sigma receptor research. Sigma receptors represent a promising, novel target for the treatment of neurodegenerative diseases, retinal degenerations, pain and substance abuse. Information is presented about tracers for molecular imaging these receptors, th...
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abstract::Euglena gracilis is a major component of the aquatic ecosystem and together with closely related species, is ubiquitous worldwide. Euglenoids are an important group of protists, possessing a secondarily acquired plastid and are relatives to the Kinetoplastidae, which themselves have global impact as disease agents. To...
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pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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更新日期:2008-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
abstract::The influenza Sentinel surveillance system is a source of valuable data about the dynamics of epidemic seasons in Poland. During the epidemic season 2016/2017, more than 1,000 samples were examined, of which 48% were positive for influenza diagnosis. The predominance of influenza A/H3N2/ was confirmed. Influenza B vir...
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更新日期:2013-01-01 00:00:00
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doi:
更新日期:2010-01-01 00:00:00
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abstract::Legume proteins are relatively deficient in the sulfur amino acids. Among the different strategies to increase the sulfur amino acid contents of legumes, we have chosen to increase the biosynthesis of endogenous, non-abundant sulfur-rich proteins we have identified in soybean seed. We identified and isolated an 8 kDa ...
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更新日期:1999-01-01 00:00:00
abstract::Considering the devastating effects of neurodegenerative disorders and the increasing number of people affected by them, an early diagnosis even presymptomatic, prior to serious mental deterioration is necessary. Therefore, screening for biomarkers, especially glycolipids, in the biological matrices, either tissues or...
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abstract::Polymyxin B is another clinically available polymyxin that has re-emerged in clinical practice to treat infections caused by multi-drug (MDR) or extensively-drug-resistant (XDR) Gram-negative bacteria (GNB). Its chemical structure is very similar to the structure of polymyxin E (colistin). However, since the latter is...
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journal_title:Advances in experimental medicine and biology
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