The Molecular Mechanisms and Prevention Principles of Muscle Atrophy in Aging.

Abstract:

:Muscle atrophy in aging is characterized by progressive loss of muscle mass and function. Muscle mass is determined by the balance of synthesis and degradation of protein, which are regulated by several signaling pathways such as ubiquitin-proteasome system, autophagy-lysosome systems, oxidative stress, proinflammatory cytokines, hormones, and so on. Sufficient nutrition can enhance protein synthesis, while exercise can improve the quality of life in the elderly. This chapter will discuss the epidemiology, pathogenesis, as well as the current treatment for aging-induced muscular atrophy.

journal_name

Adv Exp Med Biol

authors

Zhang Y,Pan X,Sun Y,Geng YJ,Yu XY,Li Y

doi

10.1007/978-981-13-1435-3_16

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

347-368

eissn

0065-2598

issn

2214-8019

journal_volume

1088

pub_type

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