Abstract:
:Muscle atrophy in aging is characterized by progressive loss of muscle mass and function. Muscle mass is determined by the balance of synthesis and degradation of protein, which are regulated by several signaling pathways such as ubiquitin-proteasome system, autophagy-lysosome systems, oxidative stress, proinflammatory cytokines, hormones, and so on. Sufficient nutrition can enhance protein synthesis, while exercise can improve the quality of life in the elderly. This chapter will discuss the epidemiology, pathogenesis, as well as the current treatment for aging-induced muscular atrophy.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Zhang Y,Pan X,Sun Y,Geng YJ,Yu XY,Li Ydoi
10.1007/978-981-13-1435-3_16subject
Has Abstractpub_date
2018-01-01 00:00:00pages
347-368eissn
0065-2598issn
2214-8019journal_volume
1088pub_type
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