Abstract:
:In this chapter, we introduce a relatively new, emerging method for molecular neuromodulation-bioluminescence-optogenetics. Bioluminescence-optogenetics is mediated by luminopsin fusion proteins-light-sensing opsins fused to light-emitting luciferases. We describe their structures and working mechanisms and discuss their unique benefits over conventional optogenetics and chemogenetics. We also summarize applications of bioluminescence-optogenetics in various neurological disease models in rodents.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Berglund K,Stern MA,Gross REdoi
10.1007/978-981-15-8763-4_17subject
Has Abstractpub_date
2021-01-01 00:00:00pages
281-293eissn
0065-2598issn
2214-8019journal_volume
1293pub_type
杂志文章abstract::Carbon compounds that are needed in small amounts in the diet because they are not made in the body of vertebrates are defined as vitamins. Excluded from this definition are vitamins D, K, and niacin which can be synthesized by the organism or, as in the case of vitamin K, by the host's intestinal bacteria. Lack of su...
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journal_title:Advances in experimental medicine and biology
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