Bioluminescence-Optogenetics.

Abstract:

:In this chapter, we introduce a relatively new, emerging method for molecular neuromodulation-bioluminescence-optogenetics. Bioluminescence-optogenetics is mediated by luminopsin fusion proteins-light-sensing opsins fused to light-emitting luciferases. We describe their structures and working mechanisms and discuss their unique benefits over conventional optogenetics and chemogenetics. We also summarize applications of bioluminescence-optogenetics in various neurological disease models in rodents.

journal_name

Adv Exp Med Biol

authors

Berglund K,Stern MA,Gross RE

doi

10.1007/978-981-15-8763-4_17

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

281-293

eissn

0065-2598

issn

2214-8019

journal_volume

1293

pub_type

杂志文章
  • The Future of Atopic Dermatitis Treatment.

    abstract::In recent years, there has been a growing movement towards the use of targeted therapies in treating of atopic dermatitis (AD), parallel to that which has occurred in psoriasis. Among the systemic medications being studied are subcutaneous or intravenously administered biologic drugs targeting specific molecules such ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-64804-0_15

    authors: Patel N,Strowd LC

    更新日期:2017-01-01 00:00:00

  • The role of renal kallikrein-kinin system and prostaglandins in diuresis and natriuresis following saline infusion in normotensives and essential hypertensives.

    abstract::In order to clarify the significance of the renal kallikrein(KAL)-kinin(KIN) system and prostaglandins (PG) in exaggerated natriuresis in essential hypertensives, the effect of acute sodium load on urinary KAL, KIN, PG, and renal water and sodium handling were investigated in normotensives (NT) and patients with essen...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4757-0154-8_42

    authors: Nishimiya T,Shimamoto K,Tanaka S,Ura N,Mita T,Nakagawa M,Maeda T,Yamaguchi Y,Masuca A,Iimura O

    更新日期:1986-01-01 00:00:00

  • Vitamin D Metabolism and the Implications for Atherosclerosis.

    abstract::Vitamin D levels and metabolism may play a role in the pathogenesis and treatment of atherosclerosis and subsequent cardiovascular health. Herein, we discuss both normal and disordered vitamin D metabolism as it pertains to atherosclerosis, and we review major clinical trials regarding vitamin D levels and effects of ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-56017-5_15

    authors: Bennett AL,Lavie CJ

    更新日期:2017-01-01 00:00:00

  • Effect of continuous melatonin infusions on steady-state plasma melatonin levels, metabolic fate and tissue retention in rats under near physiological conditions.

    abstract::The fate and disposition of melatonin released into the circulation is still poorly understood, and almost all current knowledge is derived from measurements made after one single, often very large dose of labeled melatonin. In continuous infusion experiments in freely moving rats, 500 ng melatonin/mL hr had to be inf...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-4709-9_39

    authors: Messner M,Hardeland R,Rodenbeck A,Huether G

    更新日期:1999-01-01 00:00:00

  • Fructose Consumption and Lipid Metabolism in Obese Children and Adolescents.

    abstract::Inappropriate dietary habits influence the development of excessive body weight. The role of added sugars, including fructose, notably is significant in this process. It is estimated that fructose intake has increased many times over the past two centuries. The aim of the study was to define the effect of fructose con...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2018_330

    authors: Czerwonogrodzka-Senczyna A,Rumińska M,Majcher A,Credo D,Jeznach-Steinhagen A,Pyrżak B

    更新日期:2019-01-01 00:00:00

  • Type 2 diabetes mellitus, pandemic in 21st century.

    abstract::In the second half of the 20th century it became obvious that a relentless increase in Type 2 diabetes mellitus (T2DM), affecting the economically affluent countries, is gradually afflicting also the developing world. This chapter shows the threat that the T2DM epidemic represents to mankind, with the astonishing rece...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4614-5441-0_6

    authors: Ginter E,Simko V

    更新日期:2012-01-01 00:00:00

  • The effect of the shape and size of gold seeds irradiated with ultrasound on the bio-heat transfer in tissue.

    abstract::The aim of this report is to propose a new methodology to treat prostate cancer with macro-rod-shaped gold seeds irradiated with ultrasound and develop a new computational method for temperature and thermal dose control of hyperthermia therapy induced by the proposed procedure. A computer code representation, based on...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-319-09012-2_8

    authors: Gkigkitzis I,Austerlitz C,Haranas I,Campos D

    更新日期:2015-01-01 00:00:00

  • Mig-6 Mouse Model of Endometrial Cancer.

    abstract::Endometrial cancer is a frequently occurring gynecological disorder. Estrogen-dependent endometrioid carcinoma is the most common type of gynecological cancer. One of the major pathologic phenomena of endometrial cancer is the loss of estrogen (E2) and progesterone (P4) control over uterine epithelial cell proliferati...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-319-43139-0_8

    authors: Kim TH,Yoo JY,Jeong JW

    更新日期:2017-01-01 00:00:00

  • Three-Dimensional Tissue Models and Available Probes for Multi-Parametric Live Cell Microscopy: A Brief Overview.

    abstract::In recent years, the advances in tissue engineering and regenerative medicine have resulted in introduction of novel 3D tissue models, materials and methods to the regular practice of cell biologists, material scientists and specialists from related areas. 3D tissue models allow mimicking in vivo cell and tissue organ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-67358-5_4

    authors: O'Donnell N,Dmitriev RI

    更新日期:2017-01-01 00:00:00

  • Klotho and βKlotho.

    abstract::Endocrine fibroblast growth factors (FGFs) have been recognized as hormones that regulate a variety of metabolic processes. FGF19 is secreted from intestine upon feeding and acts on liver to suppress bile acid synthesis. FGF21 is secreted from liver upon fasting and acts on adipose tissue to promote lipolysis and resp...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4614-0887-1_2

    authors: Kuro-o M

    更新日期:2012-01-01 00:00:00

  • Mitochondrial Calcium Handling in Physiology and Disease.

    abstract::Calcium (Ca2+) accumulation inside mitochondria represents a pleiotropic signal controlling a wide range of cellular functions, including key metabolic pathways and life/death decisions. This phenomenon has been first described in the 1960s, but the identity of the molecules controlling this process remained a mystery...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-55330-6_2

    authors: Granatiero V,De Stefani D,Rizzuto R

    更新日期:2017-01-01 00:00:00

  • Impact of Ultraviolet Light on Vitiligo.

    abstract::Vitiligo is a disorder of the melanocytes that results in a dynamic spectrum of skin depigmentation. Its etiology is complex and multifactorial, with data supporting several different hypotheses. Given its prominent phenotype, vitiligo has a significant negative impact on quality of life. Coupled with the chronic and ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-56017-5_5

    authors: Singh RK

    更新日期:2017-01-01 00:00:00

  • Adhesion mechanisms of staphylococci.

    abstract::Staphylococcal adherence to an either biotic or abiotic surface is the critical first event in the establishment of an infection with these serious pathogens. Especially Staphylococcus aureus harbours a variety of proteinaceous and non-proteinaceous adhesins that mediate attachment to a multitude of host factors, such...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-94-007-0940-9_7

    authors: Heilmann C

    更新日期:2011-01-01 00:00:00

  • Decreased hepatotoxicity of dimethylnitrosamine (DMN) following chronic alcohol consumption.

    abstract::Compared to controls receiving physiological saline, the i.p. administration of dimethylnitrosamine (DMN) on 5 consecutive days to rats fed a nutritionally adequate liquid diet resulted 24 hours after the last injection of significant increases in glutamic dehydrogenase (GDH), glutamic oxylacetate transaminase (GOT), ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4757-1419-7_25

    authors: Gellert J,Moreno F,Haydn M,Oldiges H,Frenzel H,Teschke R,Strohmeyer G

    更新日期:1980-01-01 00:00:00

  • Direct and Repeated Clinical Measurements of pO2 for Enhancing Cancer Therapy and Other Applications.

    abstract::The first systematic multi-center study of the clinical use of EPR oximetry has begun, with funding as a PPG from the NCI. Using particulate oxygen sensitive EPR, materials in three complementary forms (India Ink, "OxyChips", and implantable resonators) the clinical value of the technique will be evaluated. The aims i...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/978-3-319-38810-6_13

    authors: Swartz HM,Williams BB,Hou H,Khan N,Jarvis LA,Chen EY,Schaner PE,Ali A,Gallez B,Kuppusamy P,Flood AB

    更新日期:2016-01-01 00:00:00

  • Compression of foods during freeze-drying: water plasticization at the ice-dry layer interface.

    abstract::The compressive mechanical properties of freeze-dried green beans show a pronounced decrease in rigidity when moisture content and/or temperature are increased. There exist several temperature and moisture combinations which give common values for mechanical properties. These combinations also give a common compressiv...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4899-0664-9_40

    authors: Emami C,Flink JM

    更新日期:1991-01-01 00:00:00

  • Effects of alcohol on ganglion cell receptive field properties and sensitivity in the frog retina.

    abstract::Previous results have shown that alcohol has an effect on vision and on the excitability of retinal neurons. Action potentials of single ganglion cells were recorded by microelectrodes in opened and excised eyes from frogs (Rana temporaria L.). Histologically two types of synapses have been described in the retina: co...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-9038-5_13

    authors: Bäckström AC

    更新日期:1977-01-01 00:00:00

  • Advancing nanostructured porous si-based optical transducers for label free bacteria detection.

    abstract::Optical label-free porous Si-based biosensors for rapid bacteria detection are introduced. The biosensors are designed to directly capture the target bacteria cells onto their surface with no prior sample processing (such as cell lysis). Two types of nanostructured optical transducers based on oxidized porous Si (PSiO...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-94-007-2555-3_4

    authors: Massad-Ivanir N,Shtenberg G,Segal E

    更新日期:2012-01-01 00:00:00

  • Chitin: Structure, Chemistry and Biology.

    abstract::Chitin is a linear polysaccharide of the amino sugar N-acetyl glucosamine. It is present in the extracellular matrix of a variety of invertebrates including sponges, molluscs, nematodes and arthropods and fungi. Generally, it is an important component of protective or supportive extracellular matrices that cover the t...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-13-7318-3_2

    authors: Moussian B

    更新日期:2019-01-01 00:00:00

  • Structures of some new complex gangliosides of fish brain.

    abstract::Three novel trisialogangliosides of fish brain, GT3, GT2 and GT1c, have been isolated in their intact forms and their structures characterized. The discovery of these ganglioside species provides essential links for a new possible biosynthetic pathway leading to the major tetrasialoganglioside, GQ1c, of the fish brain...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-7844-0_5

    authors: Yu RK,Ando S

    更新日期:1980-01-01 00:00:00

  • Recent Progress in Vascular Tissue-Engineered Blood Vessels.

    abstract::Cardiovascular disease is the number one cause of death in the U.S and results in the loss of approximately one million lives and more than 400 billion U.S. dollars for treatments every year. Recently, tissue engineered blood vessels have been studied and developed as promising replacements for treatment with autologo...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-13-0445-3_8

    authors: Chen J,Alexander GC,Bobba PS,Jun HW

    更新日期:2018-01-01 00:00:00

  • The enthesis organ concept and its relevance to the spondyloarthropathies.

    abstract::A characteristic feature of the spondyloarthropathies is inflammation at tendon or ligament attachment sites. This has traditionally been viewed as a focal abnormality, even though the inflammatory reaction intrinsic to enthesitis may be quite extensive. We argue that the diffuse nature of the pathology is best unders...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4419-0298-6_4

    authors: Benjamin M,McGonagle D

    更新日期:2009-01-01 00:00:00

  • Impulse oscillometry in the diagnosis of airway resistance in chronic obstructive pulmonary disease.

    abstract::Spirometry is a standard lung function test for diagnosis and staging of chronic obstructive pulmonary disease (COPD). Impulse oscillometry (IOS) can be complementary to spirometry, especially in patients at advanced age and with physical or mental disorders who cannot be diagnosed through spirometry. The aim of this ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2014_49

    authors: Piorunek T,Kostrzewska M,Cofta S,Batura-Gabryel H,Andrzejczak P,Bogdański P,Wysocka E

    更新日期:2015-01-01 00:00:00

  • Synthetic cyclin dependent kinase inhibitors. New generation of potent anti-cancer drugs.

    abstract::The unsatisfactory results of current anti-cancer therapies require the active search for new drugs, new treatment strategies and a deeper understanding of the host-tumour relationship. From this point of view, the drugs with a capacity to substitute the functions of altered tumour suppressor genes are of prominent in...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:

    authors: Hajdúch M,Havlíèek L,Veselý J,Novotný R,Mihál V,Strnad M

    更新日期:1999-01-01 00:00:00

  • Demonstration of in vivo effects of ACE inhibitors by the use of autoregressive modelling.

    abstract::We investigated, with use of a technique of feedback analysis, the dynamic changes in and around the renin-angiotensin system in vivo induced by ACE inhibition. Prolonged studies were performed over a half year on rabbits, which were treated by daily injections of saline or one of the inhibitors as follows: captopril,...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-9543-4_27

    authors: Wada T,Aoyagi T

    更新日期:1989-01-01 00:00:00

  • Development of the Drosophila olfactory system.

    abstract::The olfactory system throughout the animal kingdom is characterized by a large number of highly specialized neuronal cell types. Olfactory receptor neurons (ORNs) in the peripheral sensory epithelium display two main differentiation features: the selective expression of a single odorant receptor out of a large genomic...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-0-387-78261-4_6

    authors: Rodrigues V,Hummel T

    更新日期:2008-01-01 00:00:00

  • Use of neopterin as a bone marrow hematopoietic and stromal cell growth factor in tissue-engineered devices.

    abstract::The in vitro response of early haematopoietic progenitors or stem cells (CD34+)--common for myeloid (granulocyte, eosinophil, megakaryocyte) and marrow stromal cell lineages, to neopterin, exogenously added to the liquid mouse bone marrow cultures, at doses 12.5-25 microg/ml culture medium, has been studied. The resul...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-0-387-34133-0_8

    authors: Zvetkova E,Gluhcheva Y,Fuchs D

    更新日期:2006-01-01 00:00:00

  • The effect of tryptophan deficiency in the brain on rat fatigue levels: a rat model of fatigue reduction.

    abstract::The level of tryptophan and 5-hydroxyindoleacetic acid were measured in the brain (striatum) of rats on tryptophan-deficient diet and tryptophan-enriched diet. We measured concentrations of tryptophan and 5-hydroxyindoleacetic acid in striatum by using microdialysis and HPLC methods. The extracellular level of tryptop...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-0135-0_60

    authors: Yamamoto T,Newsholme EA

    更新日期:2003-01-01 00:00:00

  • Molecular cloning and functional expression of an LLC-PK1 cell taurine transporter that is adaptively regulated by taurine.

    abstract::Studies have shown that the renal tubular epithelium adapts to alterations in the sulfur amino acid composition of the diet. The renal adaptive response has been described in man, mouse, rat, dog, and pig. The observed phenomenon involves increased or decreased initial rate activity of the NaCl-dependent taurine trans...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4899-0117-0_33

    authors: Han X,Budreau AM,Chesney RW

    更新日期:1998-01-01 00:00:00

  • Market surveillance of in vitro diagnostics by the BfArM until end 2010: safety of IVD for therapeutic drug monitoring.

    abstract::The European Directive 98/79/EC on in vitro diagnostic medical devices (IVD) regulates the marketing and post market surveillance of IVD in the European Economic Area. In cases of incidents and field corrective actions, the manufacturers have to inform the responsible Competent Authorities (CA). In Germany, the Federa...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-94-007-4546-9_48

    authors: Siekmeier R,Wetzel D

    更新日期:2013-01-01 00:00:00