Bioluminescence-Optogenetics.

Abstract:

:In this chapter, we introduce a relatively new, emerging method for molecular neuromodulation-bioluminescence-optogenetics. Bioluminescence-optogenetics is mediated by luminopsin fusion proteins-light-sensing opsins fused to light-emitting luciferases. We describe their structures and working mechanisms and discuss their unique benefits over conventional optogenetics and chemogenetics. We also summarize applications of bioluminescence-optogenetics in various neurological disease models in rodents.

journal_name

Adv Exp Med Biol

authors

Berglund K,Stern MA,Gross RE

doi

10.1007/978-981-15-8763-4_17

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

281-293

eissn

0065-2598

issn

2214-8019

journal_volume

1293

pub_type

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