Prospective Advances in Circular RNA Investigation.

Abstract:

:circRNAs have emerged as one of the key regulators in many cellular mechanisms and pathogenesis of diseases. However, with the limited knowledge and current technologies for circRNA investigations, there are several challenges that need to be addressed for. These include challenges in understanding the regulation of circRNA biogenesis, experimental designs, and sample preparations to characterize the circRNAs in diseases as well as the bioinformatics pipelines and algorithms. In this chapter, we discussed the above challenges and possible strategies to overcome those limitations. We also addressed the differences between the existing applications and technologies to study the circRNAs in diseases. By addressing these challenges, further understanding of circRNAs roles and regulations as well as the discovery of novel circRNAs could be achieved.

journal_name

Adv Exp Med Biol

authors

Sulaiman SA,Abdul Murad NA,Mohamad Hanif EA,Abu N,Jamal R

doi

10.1007/978-981-13-1426-1_28

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

357-370

eissn

0065-2598

issn

2214-8019

journal_volume

1087

pub_type

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