Abstract:
:circRNAs have emerged as one of the key regulators in many cellular mechanisms and pathogenesis of diseases. However, with the limited knowledge and current technologies for circRNA investigations, there are several challenges that need to be addressed for. These include challenges in understanding the regulation of circRNA biogenesis, experimental designs, and sample preparations to characterize the circRNAs in diseases as well as the bioinformatics pipelines and algorithms. In this chapter, we discussed the above challenges and possible strategies to overcome those limitations. We also addressed the differences between the existing applications and technologies to study the circRNAs in diseases. By addressing these challenges, further understanding of circRNAs roles and regulations as well as the discovery of novel circRNAs could be achieved.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Sulaiman SA,Abdul Murad NA,Mohamad Hanif EA,Abu N,Jamal Rdoi
10.1007/978-981-13-1426-1_28subject
Has Abstractpub_date
2018-01-01 00:00:00pages
357-370eissn
0065-2598issn
2214-8019journal_volume
1087pub_type
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