Abstract:
:Autosomal dominant Stargardt3 Macular Dystrophy (STGD3) results from mutations in the ELOVL4 gene. ELOVL4 protein localizes to the endoplasmic reticulum (ER), where it mediates the rate-limiting condensation reaction during very long-chain (VLC, ≥ C28) fatty acid biosynthesis. The defective gene product is truncated at the C-terminus, leading to mislocalization and aggregation in other organelles. In this review, we summarize our current understanding of the disease-causing mutation and its potential role in STGD3 pathogenesis.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Logan S,Anderson REdoi
10.1007/978-1-4614-3209-8_57subject
Has Abstractpub_date
2014-01-01 00:00:00pages
447-53eissn
0065-2598issn
2214-8019journal_volume
801pub_type
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