Abstract:
:Langerhans cells (LCs) are immune cells that reside in the stratified epithelium of the skin and mucosal membranes. They play a range of roles in the skin, including antigen presentation and maintenance of peripheral tolerance. Reports of LC numbers have been variable in different cancer types, with the majority of studies indicating a reduction in their number. Changes in the cytokine profile and other secreted molecules, downregulation of surface molecules on cells and hypoxia all contribute to the regulation of LCs in the tumour microenvironment. Functionally, LCs have been reported to regulate immunity and carcinogenesis in different cancer types. An improved understanding of the function and biology of LCs in tumours is essential knowledge that underpins the development of new cancer immunotherapies.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Rajesh A,Hibma Mdoi
10.1007/978-3-030-49270-0_8subject
Has Abstractpub_date
2020-01-01 00:00:00pages
147-158eissn
0065-2598issn
2214-8019journal_volume
1273pub_type
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